Tags

Type your tag names separated by a space and hit enter

Vitamin K, Vascular Calcification, and Chronic Kidney Disease: Current Evidence and Unanswered Questions.
Curr Dev Nutr 2019; 3(9):nzz077CD

Abstract

More than 15% of the US population is currently >65 y old. As populations age there is a concomitant increase in age-related chronic diseases. One such disease is chronic kidney disease (CKD), which becomes more prevalent with age, especially over age 70 y. Individuals with CKD are at increased risk of cardiovascular disease, in part because arterial calcification increases as kidney function declines. Vitamin K is a shortfall nutrient among older adults that has been implicated in arterial calcification. Evidence suggests CKD patients have low vitamin K status, but data are equivocal because the biomarkers of vitamin K status can be influenced by CKD. Animal studies provide more compelling data on the underlying role of vitamin K in arterial calcification associated with CKD. The purpose of this review is to evaluate the strengths and limitations of the available evidence regarding the role of vitamin K in CKD.

Authors+Show Affiliations

Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31598579

Citation

Shea, M Kyla, and Sarah L. Booth. "Vitamin K, Vascular Calcification, and Chronic Kidney Disease: Current Evidence and Unanswered Questions." Current Developments in Nutrition, vol. 3, no. 9, 2019, pp. nzz077.
Shea MK, Booth SL. Vitamin K, Vascular Calcification, and Chronic Kidney Disease: Current Evidence and Unanswered Questions. Curr Dev Nutr. 2019;3(9):nzz077.
Shea, M. K., & Booth, S. L. (2019). Vitamin K, Vascular Calcification, and Chronic Kidney Disease: Current Evidence and Unanswered Questions. Current Developments in Nutrition, 3(9), pp. nzz077. doi:10.1093/cdn/nzz077.
Shea MK, Booth SL. Vitamin K, Vascular Calcification, and Chronic Kidney Disease: Current Evidence and Unanswered Questions. Curr Dev Nutr. 2019;3(9):nzz077. PubMed PMID: 31598579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin K, Vascular Calcification, and Chronic Kidney Disease: Current Evidence and Unanswered Questions. AU - Shea,M Kyla, AU - Booth,Sarah L, Y1 - 2019/07/04/ PY - 2019/04/16/received PY - 2019/06/12/revised PY - 2019/06/26/accepted PY - 2019/10/11/entrez PY - 2019/10/11/pubmed PY - 2019/10/11/medline KW - cardiovascular disease KW - chronic kidney disease KW - coronary artery calcium KW - phylloquinone KW - vitamin K SP - nzz077 EP - nzz077 JF - Current developments in nutrition JO - Curr Dev Nutr VL - 3 IS - 9 N2 - More than 15% of the US population is currently >65 y old. As populations age there is a concomitant increase in age-related chronic diseases. One such disease is chronic kidney disease (CKD), which becomes more prevalent with age, especially over age 70 y. Individuals with CKD are at increased risk of cardiovascular disease, in part because arterial calcification increases as kidney function declines. Vitamin K is a shortfall nutrient among older adults that has been implicated in arterial calcification. Evidence suggests CKD patients have low vitamin K status, but data are equivocal because the biomarkers of vitamin K status can be influenced by CKD. Animal studies provide more compelling data on the underlying role of vitamin K in arterial calcification associated with CKD. The purpose of this review is to evaluate the strengths and limitations of the available evidence regarding the role of vitamin K in CKD. SN - 2475-2991 UR - https://www.unboundmedicine.com/medline/citation/31598579/Vitamin_K,_Vascular_Calcification,_and_Chronic_Kidney_Disease:_Current_Evidence_and_Unanswered_Questions L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31598579/ DB - PRIME DP - Unbound Medicine ER -