Tags

Type your tag names separated by a space and hit enter

Correlations of IL-6 and CRP gene polymorphisms with pulmonary heart disease.
Eur Rev Med Pharmacol Sci 2019; 23(18):8109-8114ER

Abstract

OBJECTIVE

To explore the correlations of interleukin-6 (IL-6) and C-reactive protein (CRP) gene polymorphisms with pulmonary heart disease (PHD).

PATIENTS AND METHODS

A total of 98 patients with PHD and 102 healthy persons receiving physical examinations were enrolled. Their general clinical information was collected, and the levels of IL-6 and CRP in the plasma were determined. The pulmonary functions and blood gas were detected, and the TaqMan-minor groove binder (MGB) probe was used to detect the polymorphisms of IL-6 rs1800796 and CRP rs1800796.

RESULTS

Observation group had higher levels of IL-6 and CRP than control group (p<0.05). The forced expiratory volume in 1 second (FEV1) (%), FEV1/forced vital capacity (FVC) ratio (%), and arterial partial pressure of oxygen (PaO2) in observation group were lower than those in control group (p<0.05), but the arterial partial pressure of carbon dioxide (PaCO2) was higher than that in control group (p<0.05). There were differences in the distribution frequencies of the genotypes and alleles of IL-6 rs1800796 and CRP rs1800796 between the two groups (p<0.05).

CONCLUSIONS

IL-6 and CRP are correlated with the onset of PHD, and there are also correlations between the polymorphisms of IL-6 rs1800796 and CRP rs2794521 and the disease.

Authors+Show Affiliations

Department of Cardiology, Ningxia Hui Autonomous Region People's Hospital, The First Affiliated Hospital of Northwest University for Nationalities, Yinchuan, China. zyhxnkbsr@163.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31599438

Citation

Wu, Y, et al. "Correlations of IL-6 and CRP Gene Polymorphisms With Pulmonary Heart Disease." European Review for Medical and Pharmacological Sciences, vol. 23, no. 18, 2019, pp. 8109-8114.
Wu Y, Bai SR, Wei SJ, et al. Correlations of IL-6 and CRP gene polymorphisms with pulmonary heart disease. Eur Rev Med Pharmacol Sci. 2019;23(18):8109-8114.
Wu, Y., Bai, S. R., Wei, S. J., Ge, L. J., & Xi, S. J. (2019). Correlations of IL-6 and CRP gene polymorphisms with pulmonary heart disease. European Review for Medical and Pharmacological Sciences, 23(18), pp. 8109-8114. doi:10.26355/eurrev_201909_19029.
Wu Y, et al. Correlations of IL-6 and CRP Gene Polymorphisms With Pulmonary Heart Disease. Eur Rev Med Pharmacol Sci. 2019;23(18):8109-8114. PubMed PMID: 31599438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlations of IL-6 and CRP gene polymorphisms with pulmonary heart disease. AU - Wu,Y, AU - Bai,S-R, AU - Wei,S-J, AU - Ge,L-J, AU - Xi,S-J, PY - 2019/10/11/entrez SP - 8109 EP - 8114 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 23 IS - 18 N2 - OBJECTIVE: To explore the correlations of interleukin-6 (IL-6) and C-reactive protein (CRP) gene polymorphisms with pulmonary heart disease (PHD). PATIENTS AND METHODS: A total of 98 patients with PHD and 102 healthy persons receiving physical examinations were enrolled. Their general clinical information was collected, and the levels of IL-6 and CRP in the plasma were determined. The pulmonary functions and blood gas were detected, and the TaqMan-minor groove binder (MGB) probe was used to detect the polymorphisms of IL-6 rs1800796 and CRP rs1800796. RESULTS: Observation group had higher levels of IL-6 and CRP than control group (p<0.05). The forced expiratory volume in 1 second (FEV1) (%), FEV1/forced vital capacity (FVC) ratio (%), and arterial partial pressure of oxygen (PaO2) in observation group were lower than those in control group (p<0.05), but the arterial partial pressure of carbon dioxide (PaCO2) was higher than that in control group (p<0.05). There were differences in the distribution frequencies of the genotypes and alleles of IL-6 rs1800796 and CRP rs1800796 between the two groups (p<0.05). CONCLUSIONS: IL-6 and CRP are correlated with the onset of PHD, and there are also correlations between the polymorphisms of IL-6 rs1800796 and CRP rs2794521 and the disease. SN - 2284-0729 UR - https://www.unboundmedicine.com/medline/citation/31599438/Correlations_of_IL-6_and_CRP_gene_polymorphisms_with_pulmonary_heart_disease L2 - https://www.europeanreview.org/article/19029 DB - PRIME DP - Unbound Medicine ER -