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Neural Basis of Observational Fear Learning: A Potential Model of Affective Empathy.
Neuron. 2019 10 09; 104(1):78-86.N

Abstract

Observational fear learning in rodents is a type of context-dependent fear conditioning in which an unconditioned stimulus (US) is provided vicariously by observing conspecific others receiving foot shocks. This suggests the involvement of affective empathy, with several recent studies showing many similarities between this behavior and human empathy. Neurobiologically, it is important to understand the neural mechanisms by which the vicarious US activates the fear circuit via the affective pain system, obviating the sensory pain pathway and eventually leading to fear memory formation. This paper reviews current studies on the neural mechanisms underlying observational fear learning and provides a perspective on future research on this subject.

Authors+Show Affiliations

Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, Republic of Korea. Electronic address: sdukeum@ibs.re.kr.Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, Republic of Korea. Electronic address: shin@ibs.re.kr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

31600517

Citation

Keum, Sehoon, and Hee-Sup Shin. "Neural Basis of Observational Fear Learning: a Potential Model of Affective Empathy." Neuron, vol. 104, no. 1, 2019, pp. 78-86.
Keum S, Shin HS. Neural Basis of Observational Fear Learning: A Potential Model of Affective Empathy. Neuron. 2019;104(1):78-86.
Keum, S., & Shin, H. S. (2019). Neural Basis of Observational Fear Learning: A Potential Model of Affective Empathy. Neuron, 104(1), 78-86. https://doi.org/10.1016/j.neuron.2019.09.013
Keum S, Shin HS. Neural Basis of Observational Fear Learning: a Potential Model of Affective Empathy. Neuron. 2019 10 9;104(1):78-86. PubMed PMID: 31600517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neural Basis of Observational Fear Learning: A Potential Model of Affective Empathy. AU - Keum,Sehoon, AU - Shin,Hee-Sup, PY - 2019/08/13/received PY - 2019/09/03/revised PY - 2019/09/09/accepted PY - 2019/10/11/entrez PY - 2019/10/11/pubmed PY - 2020/4/1/medline KW - affective pain KW - and anterior cingulate cortex KW - empathy KW - observational fear learning KW - social fear SP - 78 EP - 86 JF - Neuron JO - Neuron VL - 104 IS - 1 N2 - Observational fear learning in rodents is a type of context-dependent fear conditioning in which an unconditioned stimulus (US) is provided vicariously by observing conspecific others receiving foot shocks. This suggests the involvement of affective empathy, with several recent studies showing many similarities between this behavior and human empathy. Neurobiologically, it is important to understand the neural mechanisms by which the vicarious US activates the fear circuit via the affective pain system, obviating the sensory pain pathway and eventually leading to fear memory formation. This paper reviews current studies on the neural mechanisms underlying observational fear learning and provides a perspective on future research on this subject. SN - 1097-4199 UR - https://www.unboundmedicine.com/medline/citation/31600517/Neural_Basis_of_Observational_Fear_Learning:_A_Potential_Model_of_Affective_Empathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0896-6273(19)30786-X DB - PRIME DP - Unbound Medicine ER -