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Soluble mannose receptor as a predictor of prognosis of hepatitis B virus-related acute-on-chronic liver failure.
World J Gastroenterol. 2019 Oct 07; 25(37):5667-5675.WJ

Abstract

BACKGROUND

Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a syndrome with a high short-term mortality rate, and it is crucial to identify those patients at a high mortality risk clinically.

AIM

To investigate the clinical value of soluble mannose receptor (sMR) in predicting the 90-day mortality of HBV-ACLF patients.

METHODS

A total of 43 patients were diagnosed with HBV-ACLF between October 2017 and October 2018 at the Second Hospital of Anhui Medical University, and all of them were enrolled in this retrospective study. Their serum sMR levels were determined using an enzyme-linked immunosorbent assay. Demographic and clinical data, including gender, age, albumin level, total bilirubin (TBIL) level, international normalized ratio, HBV-DNA level, HBV serological markers, procalcitonin level, interleukin-6 level, and model for end-stage liver disease (MELD) score were accessed at the time of diagnosis of HBV-ACLF. A multivariate logistic regression analysis was used to analyze the independent risk factors for mortality.

RESULTS

Serum sMR level was significantly increased in HBV-ACLF patients compared with chronic hepatitis B patients and healthy controls (P < 0.01). When compared with surviving patients, it was higher in those patients who succumbed to HBV-ACLF (P < 0.05). Serum sMR level was positively correlated with MELD score (r s = 0.533, P = 0.001), HBV-DNA level (r s = 0.497, P = 0.022), and TBIL level (r s = 0.894, P < 0.001). Serum sMR level (odds ratio = 1.007, 95% confidence interval: 1.004-1.012, P = 0.001) was an independent risk factor for the 90-day mortality in the HBV-ACLF cases. The patients with HBV-ACLF were stratified into two groups in accordance with their serum sMR levels at the baseline (low risk: < 99.84 pg/mL and high risk: ≥ 99.84 pg/mL). The 90-day mortality rates were 27.3% in the low-risk group and 87.5% in the high-risk group. Furthermore, sMR level apparently improved the performance of MELD score for predicting the prognosis of patients with HBV-ACLF.

CONCLUSION

Serum sMR level may be a predictor of the prognosis of HBV-ACLF patients.

Authors+Show Affiliations

Department of Clinical Laboratory, The Second Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China.Department of Clinical Laboratory, The Second Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China. shiheguan@126.com.Department of Clinical Laboratory, The Second Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China.Department of Clinical Laboratory, The Second Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China.Department of Clinical Laboratory, The Second Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China.Department of Clinical Laboratory, The Second Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31602166

Citation

Li, Tai-Ping, et al. "Soluble Mannose Receptor as a Predictor of Prognosis of Hepatitis B Virus-related Acute-on-chronic Liver Failure." World Journal of Gastroenterology, vol. 25, no. 37, 2019, pp. 5667-5675.
Li TP, Guan SH, Wang Q, et al. Soluble mannose receptor as a predictor of prognosis of hepatitis B virus-related acute-on-chronic liver failure. World J Gastroenterol. 2019;25(37):5667-5675.
Li, T. P., Guan, S. H., Wang, Q., Chen, L. W., Yang, K., & Zhang, H. (2019). Soluble mannose receptor as a predictor of prognosis of hepatitis B virus-related acute-on-chronic liver failure. World Journal of Gastroenterology, 25(37), 5667-5675. https://doi.org/10.3748/wjg.v25.i37.5667
Li TP, et al. Soluble Mannose Receptor as a Predictor of Prognosis of Hepatitis B Virus-related Acute-on-chronic Liver Failure. World J Gastroenterol. 2019 Oct 7;25(37):5667-5675. PubMed PMID: 31602166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soluble mannose receptor as a predictor of prognosis of hepatitis B virus-related acute-on-chronic liver failure. AU - Li,Tai-Ping, AU - Guan,Shi-He, AU - Wang,Qin, AU - Chen,Li-Wen, AU - Yang,Kai, AU - Zhang,Hao, PY - 2019/07/15/received PY - 2019/08/21/revised PY - 2019/09/11/accepted PY - 2019/10/12/entrez PY - 2019/10/12/pubmed PY - 2020/2/27/medline KW - Acute-on-chronic liver failure KW - Mannose receptor KW - Model for end-stage liver disease KW - Prognosis KW - Risk factor SP - 5667 EP - 5675 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 25 IS - 37 N2 - BACKGROUND: Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a syndrome with a high short-term mortality rate, and it is crucial to identify those patients at a high mortality risk clinically. AIM: To investigate the clinical value of soluble mannose receptor (sMR) in predicting the 90-day mortality of HBV-ACLF patients. METHODS: A total of 43 patients were diagnosed with HBV-ACLF between October 2017 and October 2018 at the Second Hospital of Anhui Medical University, and all of them were enrolled in this retrospective study. Their serum sMR levels were determined using an enzyme-linked immunosorbent assay. Demographic and clinical data, including gender, age, albumin level, total bilirubin (TBIL) level, international normalized ratio, HBV-DNA level, HBV serological markers, procalcitonin level, interleukin-6 level, and model for end-stage liver disease (MELD) score were accessed at the time of diagnosis of HBV-ACLF. A multivariate logistic regression analysis was used to analyze the independent risk factors for mortality. RESULTS: Serum sMR level was significantly increased in HBV-ACLF patients compared with chronic hepatitis B patients and healthy controls (P < 0.01). When compared with surviving patients, it was higher in those patients who succumbed to HBV-ACLF (P < 0.05). Serum sMR level was positively correlated with MELD score (r s = 0.533, P = 0.001), HBV-DNA level (r s = 0.497, P = 0.022), and TBIL level (r s = 0.894, P < 0.001). Serum sMR level (odds ratio = 1.007, 95% confidence interval: 1.004-1.012, P = 0.001) was an independent risk factor for the 90-day mortality in the HBV-ACLF cases. The patients with HBV-ACLF were stratified into two groups in accordance with their serum sMR levels at the baseline (low risk: < 99.84 pg/mL and high risk: ≥ 99.84 pg/mL). The 90-day mortality rates were 27.3% in the low-risk group and 87.5% in the high-risk group. Furthermore, sMR level apparently improved the performance of MELD score for predicting the prognosis of patients with HBV-ACLF. CONCLUSION: Serum sMR level may be a predictor of the prognosis of HBV-ACLF patients. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/31602166/Soluble_mannose_receptor_as_a_predictor_of_prognosis_of_hepatitis_B_virus_related_acute_on_chronic_liver_failure_ L2 - http://www.wjgnet.com/1007-9327/full/v25/i37/5667.htm DB - PRIME DP - Unbound Medicine ER -