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Assessing the Interocular Symmetry of Foveal Outer Nuclear Layer Thickness in Achromatopsia.
Transl Vis Sci Technol 2019; 8(5):21TV

Abstract

Purpose

We examine the interocular symmetry of foveal outer nuclear layer (ONL) thickness measurements in subjects with achromatopsia (ACHM).

Methods

Images from 76 subjects with CNGA3- or CNGB3-associated ACHM and 42 control subjects were included in the study. Line or volume scans through the fovea of each eye were acquired using optical coherence tomography (OCT). Image quality was assessed for each image included in the analysis using a previously-described maximum tissue contrast index (mTCI) metric. Three foveal ONL thickness measurements were made by a single observer and interocular symmetry was assessed using the average of the three measurements for each eye.

Results

Mean (± standard deviation) foveal ONL thickness for subjects with ACHM was 79.7 ± 18.3 μm (right eye) and 79.2 ± 18.7 μm (left eye) compared to 112.9 ± 15.2 (right eye) and 112.1 ± 13.9 μm (left eye) for controls. Foveal ONL thickness did not differ between eyes for ACHM (P = 0.636) or control subjects (P = 0.434). No significant relationship between mTCI and observer repeatability was observed for either control (P = 0.140) or ACHM (P = 0.351) images.

Conclusions

While foveal ONL thickness is reduced in ACHM compared to controls, the high interocular symmetry indicates that contralateral ONL measurements could be used as a negative control in early-phase monocular treatment trials.

Translational Relevance

Foveal ONL thickness can be measured using OCT images over a wide range of image quality. The interocular symmetry of foveal ONL thickness in ACHM and control populations supports the use of the non-study eye as a control for clinical trial purposes.

Authors+Show Affiliations

Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.Cell Biology, Neurobiology, & Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA. University of Minnesota Medical School, Minneapolis, MN, USA.Institute of Ophthalmology, University College London, London, EC1V 9EL, UK. Moorfields Eye Hospital, London, EC1V 2PD, UK.Institute of Ophthalmology, University College London, London, EC1V 9EL, UK. Moorfields Eye Hospital, London, EC1V 2PD, UK.Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA. Cell Biology, Neurobiology, & Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31602346

Citation

Mastey, Rebecca R., et al. "Assessing the Interocular Symmetry of Foveal Outer Nuclear Layer Thickness in Achromatopsia." Translational Vision Science & Technology, vol. 8, no. 5, 2019, p. 21.
Mastey RR, Gaffney M, Litts KM, et al. Assessing the Interocular Symmetry of Foveal Outer Nuclear Layer Thickness in Achromatopsia. Transl Vis Sci Technol. 2019;8(5):21.
Mastey, R. R., Gaffney, M., Litts, K. M., Langlo, C. S., Patterson, E. J., Strampe, M. R., ... Carroll, J. (2019). Assessing the Interocular Symmetry of Foveal Outer Nuclear Layer Thickness in Achromatopsia. Translational Vision Science & Technology, 8(5), p. 21. doi:10.1167/tvst.8.5.21.
Mastey RR, et al. Assessing the Interocular Symmetry of Foveal Outer Nuclear Layer Thickness in Achromatopsia. Transl Vis Sci Technol. 2019;8(5):21. PubMed PMID: 31602346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessing the Interocular Symmetry of Foveal Outer Nuclear Layer Thickness in Achromatopsia. AU - Mastey,Rebecca R, AU - Gaffney,Mina, AU - Litts,Katie M, AU - Langlo,Christopher S, AU - Patterson,Emily J, AU - Strampe,Margaret R, AU - Kalitzeos,Angelos, AU - Michaelides,Michel, AU - Carroll,Joseph, Y1 - 2019/10/02/ PY - 2019/02/14/received PY - 2019/08/12/accepted PY - 2019/10/12/entrez PY - 2019/10/12/pubmed PY - 2019/10/12/medline KW - achromatopsia KW - optical coherence tomography KW - outer nuclear layer SP - 21 EP - 21 JF - Translational vision science & technology JO - Transl Vis Sci Technol VL - 8 IS - 5 N2 - Purpose: We examine the interocular symmetry of foveal outer nuclear layer (ONL) thickness measurements in subjects with achromatopsia (ACHM). Methods: Images from 76 subjects with CNGA3- or CNGB3-associated ACHM and 42 control subjects were included in the study. Line or volume scans through the fovea of each eye were acquired using optical coherence tomography (OCT). Image quality was assessed for each image included in the analysis using a previously-described maximum tissue contrast index (mTCI) metric. Three foveal ONL thickness measurements were made by a single observer and interocular symmetry was assessed using the average of the three measurements for each eye. Results: Mean (± standard deviation) foveal ONL thickness for subjects with ACHM was 79.7 ± 18.3 μm (right eye) and 79.2 ± 18.7 μm (left eye) compared to 112.9 ± 15.2 (right eye) and 112.1 ± 13.9 μm (left eye) for controls. Foveal ONL thickness did not differ between eyes for ACHM (P = 0.636) or control subjects (P = 0.434). No significant relationship between mTCI and observer repeatability was observed for either control (P = 0.140) or ACHM (P = 0.351) images. Conclusions: While foveal ONL thickness is reduced in ACHM compared to controls, the high interocular symmetry indicates that contralateral ONL measurements could be used as a negative control in early-phase monocular treatment trials. Translational Relevance: Foveal ONL thickness can be measured using OCT images over a wide range of image quality. The interocular symmetry of foveal ONL thickness in ACHM and control populations supports the use of the non-study eye as a control for clinical trial purposes. SN - 2164-2591 UR - https://www.unboundmedicine.com/medline/citation/31602346/Assessing_the_Interocular_Symmetry_of_Foveal_Outer_Nuclear_Layer_Thickness_in_Achromatopsia L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31602346/ DB - PRIME DP - Unbound Medicine ER -