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Next-Generation HIV Pre-Exposure Prophylaxis Preferences Among Men Who Have Sex with Men Taking Daily Oral Pre-Exposure Prophylaxis.
AIDS Patient Care STDS 2019; 33(11):482-491AP

Abstract

Next-generation forms of HIV pre-exposure prophylaxis (PrEP) currently in development, including long-acting injectables (LAIs), rectal microbicides (RMs), antibody infusions (AIs), and subdermal implants (SIs), may address barriers to daily oral PrEP uptake and adherence. The purpose of this study was to evaluate barriers to oral PrEP, preferences for next-generation PrEP modalities, sociodemographic characteristics and sexual behaviors associated with preferences, and reasons for wanting or not wanting each formulation among a sample of men who have sex with men (MSM). We administered a cross-sectional survey to a diverse sample of MSM currently taking oral PrEP (n = 108) at two sexually transmitted disease clinics. We used logistic multivariate analyses to explore preferences, relative to oral PrEP, for each formulation across sociodemographic and sexual behaviors. The most commonly endorsed barriers were finding a PrEP provider and making appointments to get PrEP. Participants were most likely to prefer the SI (45%), followed by the LAI (31%), pill (21%), RM (1%), and AI (1%). Black/African American and Hispanic/Latino MSM were more likely to prefer the LAI over daily oral PrEP (odds ratio: 2.45, 95% confidence interval: 0.86-6.89), and sexual behaviors were most commonly associated with preference for the SI. Top reasons for wanting or not wanting each formulation were most commonly related to perceived ease of use. These findings demonstrate variations in preferences for next-generation PrEP modalities, highlighting a need to ensure comprehensive access to all formulations once they become available.

Authors+Show Affiliations

Department of Health Law, Policy & Management, Boston University School of Public Health, Boston, Massachusetts.Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, Rhode Island. Center for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, Rhode Island. Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island.Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, Rhode Island. Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island.Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island.Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut.Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, Rhode Island.Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, Rhode Island. Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31603712

Citation

Ellison, Jacqueline, et al. "Next-Generation HIV Pre-Exposure Prophylaxis Preferences Among Men Who Have Sex With Men Taking Daily Oral Pre-Exposure Prophylaxis." AIDS Patient Care and STDs, vol. 33, no. 11, 2019, pp. 482-491.
Ellison J, van den Berg JJ, Montgomery MC, et al. Next-Generation HIV Pre-Exposure Prophylaxis Preferences Among Men Who Have Sex with Men Taking Daily Oral Pre-Exposure Prophylaxis. AIDS Patient Care STDS. 2019;33(11):482-491.
Ellison, J., van den Berg, J. J., Montgomery, M. C., Tao, J., Pashankar, R., Mimiaga, M. J., & Chan, P. A. (2019). Next-Generation HIV Pre-Exposure Prophylaxis Preferences Among Men Who Have Sex with Men Taking Daily Oral Pre-Exposure Prophylaxis. AIDS Patient Care and STDs, 33(11), pp. 482-491. doi:10.1089/apc.2019.0093.
Ellison J, et al. Next-Generation HIV Pre-Exposure Prophylaxis Preferences Among Men Who Have Sex With Men Taking Daily Oral Pre-Exposure Prophylaxis. AIDS Patient Care STDS. 2019;33(11):482-491. PubMed PMID: 31603712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Next-Generation HIV Pre-Exposure Prophylaxis Preferences Among Men Who Have Sex with Men Taking Daily Oral Pre-Exposure Prophylaxis. AU - Ellison,Jacqueline, AU - van den Berg,Jacob J, AU - Montgomery,Madeline C, AU - Tao,Jun, AU - Pashankar,Rashmi, AU - Mimiaga,Matthew J, AU - Chan,Philip A, Y1 - 2019/10/11/ PY - 2020/11/01/pmc-release PY - 2019/10/12/pubmed PY - 2019/10/12/medline PY - 2019/10/12/entrez KW - HIV prevention KW - men who have sex with men KW - next-generation biomedical interventions KW - pre-exposure prophylaxis SP - 482 EP - 491 JF - AIDS patient care and STDs JO - AIDS Patient Care STDS VL - 33 IS - 11 N2 - Next-generation forms of HIV pre-exposure prophylaxis (PrEP) currently in development, including long-acting injectables (LAIs), rectal microbicides (RMs), antibody infusions (AIs), and subdermal implants (SIs), may address barriers to daily oral PrEP uptake and adherence. The purpose of this study was to evaluate barriers to oral PrEP, preferences for next-generation PrEP modalities, sociodemographic characteristics and sexual behaviors associated with preferences, and reasons for wanting or not wanting each formulation among a sample of men who have sex with men (MSM). We administered a cross-sectional survey to a diverse sample of MSM currently taking oral PrEP (n = 108) at two sexually transmitted disease clinics. We used logistic multivariate analyses to explore preferences, relative to oral PrEP, for each formulation across sociodemographic and sexual behaviors. The most commonly endorsed barriers were finding a PrEP provider and making appointments to get PrEP. Participants were most likely to prefer the SI (45%), followed by the LAI (31%), pill (21%), RM (1%), and AI (1%). Black/African American and Hispanic/Latino MSM were more likely to prefer the LAI over daily oral PrEP (odds ratio: 2.45, 95% confidence interval: 0.86-6.89), and sexual behaviors were most commonly associated with preference for the SI. Top reasons for wanting or not wanting each formulation were most commonly related to perceived ease of use. These findings demonstrate variations in preferences for next-generation PrEP modalities, highlighting a need to ensure comprehensive access to all formulations once they become available. SN - 1557-7449 UR - https://www.unboundmedicine.com/medline/citation/31603712/Next-Generation_HIV_Pre-Exposure_Prophylaxis_Preferences_Among_Men_Who_Have_Sex_with_Men_Taking_Daily_Oral_Pre-Exposure_Prophylaxis L2 - https://www.liebertpub.com/doi/full/10.1089/apc.2019.0093?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -