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Corneal higher-order aberrations in eyes with chronic ocular graft-versus-host disease.
Ocul Surf 2019OS

Abstract

PURPOSE

Chronic ocular graft-versus-host disease (GVHD) is a long-term complication after hematopoietic stem cell transplantation (HSCT) and leads to irreversible visual morbidity due to severe ocular surface impairments including visual disfunction. However, knowledge about the optical function in chronic ocular GVHD is limited because it is difficult to assess quantitative optical function objectively. The development of anterior segment optical coherence tomography has allowed objective quantification of optical function by evaluating corneal higher-order aberrations (HOAs). Therefore, we applied this quantification in chronic ocular GVHD patients and verified the correlation between corneal HOAs and visual acuity.

METHODS

We retrospectively reviewed chronic ocular GVHD patients and the recipients after HSCT. Then, analyzed the relationship between visual function and the severity of chronic ocular GVHD.

RESULTS

The eyes of patients with chronic ocular GVHD had higher corneal HOAs than those of non-GVHD patients (HOAs; 0.481 ± 0.306 vs 0.254 ± 0.084, and 0.917 ± 0.609 vs 0.529 ± 0.130. P < 0.001, and 0.002. 4-mm and 6-mm diameters respectively. Corneal HOAs were correlated with the severity of chronic ocular GVHD (r = 0.436. P < 0.001). Moreover, corneal HOAs were correlated with visual acuity, especially in eyes with severe chronic ocular GVHD cases (HOAs; 4-mm r = 0.636. P = 0.036. Total 6-mm r = 0.871. P =<0.001).

CONCLUSIONS

We succeed to assess the objective value in the optical function of the chronic ocular GVHD. Quantification of corneal HOAs could be an objective evaluation to assess optical function in eyes with chronic ocular GVHD.

Authors+Show Affiliations

Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan. Electronic address: ophthalmolog1st.acek39@keio.jp.Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan; Department of Ophthalmology, Tsurumi University School of Dental Medicine, Kanagawa, Japan.Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.Department of Preventive Medicine and Public Health, Biostatistics at Clinical and Translational Research Center, Keio University School of Medicine, Tokyo, Japan.Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan. Electronic address: yoko@z7.keio.jp.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31605785

Citation

Shimizu, Eisuke, et al. "Corneal Higher-order Aberrations in Eyes With Chronic Ocular Graft-versus-host Disease." The Ocular Surface, 2019.
Shimizu E, Aketa N, Yazu H, et al. Corneal higher-order aberrations in eyes with chronic ocular graft-versus-host disease. Ocul Surf. 2019.
Shimizu, E., Aketa, N., Yazu, H., Uchino, M., Kamoi, M., Sato, Y., ... Ogawa, Y. (2019). Corneal higher-order aberrations in eyes with chronic ocular graft-versus-host disease. The Ocular Surface, doi:10.1016/j.jtos.2019.10.005.
Shimizu E, et al. Corneal Higher-order Aberrations in Eyes With Chronic Ocular Graft-versus-host Disease. Ocul Surf. 2019 Oct 9; PubMed PMID: 31605785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Corneal higher-order aberrations in eyes with chronic ocular graft-versus-host disease. AU - Shimizu,Eisuke, AU - Aketa,Naohiko, AU - Yazu,Hiroyuki, AU - Uchino,Miki, AU - Kamoi,Mizuka, AU - Sato,Yasunori, AU - Tsubota,Kazuo, AU - Ogawa,Yoko, Y1 - 2019/10/09/ PY - 2019/08/06/received PY - 2019/10/04/revised PY - 2019/10/08/accepted PY - 2019/10/13/pubmed PY - 2019/10/13/medline PY - 2019/10/13/entrez KW - Dry eye disease KW - Graft-versus-host disease KW - Higher-order aberration KW - Irregular astigmatism KW - Visual acuity JF - The ocular surface JO - Ocul Surf N2 - PURPOSE: Chronic ocular graft-versus-host disease (GVHD) is a long-term complication after hematopoietic stem cell transplantation (HSCT) and leads to irreversible visual morbidity due to severe ocular surface impairments including visual disfunction. However, knowledge about the optical function in chronic ocular GVHD is limited because it is difficult to assess quantitative optical function objectively. The development of anterior segment optical coherence tomography has allowed objective quantification of optical function by evaluating corneal higher-order aberrations (HOAs). Therefore, we applied this quantification in chronic ocular GVHD patients and verified the correlation between corneal HOAs and visual acuity. METHODS: We retrospectively reviewed chronic ocular GVHD patients and the recipients after HSCT. Then, analyzed the relationship between visual function and the severity of chronic ocular GVHD. RESULTS: The eyes of patients with chronic ocular GVHD had higher corneal HOAs than those of non-GVHD patients (HOAs; 0.481 ± 0.306 vs 0.254 ± 0.084, and 0.917 ± 0.609 vs 0.529 ± 0.130. P < 0.001, and 0.002. 4-mm and 6-mm diameters respectively. Corneal HOAs were correlated with the severity of chronic ocular GVHD (r = 0.436. P < 0.001). Moreover, corneal HOAs were correlated with visual acuity, especially in eyes with severe chronic ocular GVHD cases (HOAs; 4-mm r = 0.636. P = 0.036. Total 6-mm r = 0.871. P =<0.001). CONCLUSIONS: We succeed to assess the objective value in the optical function of the chronic ocular GVHD. Quantification of corneal HOAs could be an objective evaluation to assess optical function in eyes with chronic ocular GVHD. SN - 1937-5913 UR - https://www.unboundmedicine.com/medline/citation/31605785/Corneal_higher-order_aberrations_in_eyes_with_chronic_ocular_graft-versus-host_disease L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-0124(19)30291-5 DB - PRIME DP - Unbound Medicine ER -