Tags

Type your tag names separated by a space and hit enter

An Integrative Survival Analysis for Multicentric Low-Grade Glioma.

Abstract

OBJECTIVE

This study aimed to perform a survival analysis of patients with multicentric low-grade gliomas (MLGGs) and to assess the influence of various prognostic factors on progression-free survival (PFS) and overall survival.

METHODS

A literature search on Web of Science and PubMed was performed for literature in English published from 1963 to September 2018. Detailed information including demographics, clinical characteristics, treatments, critical events, and time to events for survival analysis were extracted from the included articles.

RESULTS

A total of 36 cases from published articles were selected for analysis. Univariate analysis showed that age (<31 years or ≥31 years), grade (pure low grade/low and high grade) and glioma type (astrocytoma/oligodendroglioma) had a significant relationship with PFS. Cox regression analysis showed that tumor grade was an independent prognostic factor for PFS. No factors correlated with overall survival.

CONCLUSIONS

This integrative analysis of MLGGs patients revealed that age younger than 31 years, pure MLGG, and oligodendroglioma were significantly associated with improved PFS, and pure MLGGs was an independent prognostic factors for PFS.

Authors+Show Affiliations

Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.Department of Neurosurgery, Xi'an Central Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, China.Department of Neurology, Xi'an Children's Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, China.Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.Department of Neurology, Xi'an Children's Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, China.Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Shanghai Cancer Center, Shanghai, China.Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address: qiuzhouba@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31605855

Citation

Wang, Tianwei, et al. "An Integrative Survival Analysis for Multicentric Low-Grade Glioma." World Neurosurgery, 2019.
Wang T, Yang Y, Xu X, et al. An Integrative Survival Analysis for Multicentric Low-Grade Glioma. World Neurosurg. 2019.
Wang, T., Yang, Y., Xu, X., Niu, X., Yang, R., Gao, T., ... Qiu, Y. (2019). An Integrative Survival Analysis for Multicentric Low-Grade Glioma. World Neurosurgery, doi:10.1016/j.wneu.2019.10.001.
Wang T, et al. An Integrative Survival Analysis for Multicentric Low-Grade Glioma. World Neurosurg. 2019 Oct 9; PubMed PMID: 31605855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An Integrative Survival Analysis for Multicentric Low-Grade Glioma. AU - Wang,Tianwei, AU - Yang,Yanping, AU - Xu,Xiaoke, AU - Niu,Xiaodong, AU - Yang,Renhao, AU - Gao,Ting, AU - Kong,Lin, AU - Mao,Qing, AU - Qiu,Yongming, Y1 - 2019/10/09/ PY - 2019/07/23/received PY - 2019/09/30/revised PY - 2019/10/01/accepted PY - 2019/10/13/pubmed PY - 2019/10/13/medline PY - 2019/10/13/entrez KW - Multicentric low-grade glioma KW - Oligodendroglioma KW - Prognosis KW - Progression-free survival JF - World neurosurgery JO - World Neurosurg N2 - OBJECTIVE: This study aimed to perform a survival analysis of patients with multicentric low-grade gliomas (MLGGs) and to assess the influence of various prognostic factors on progression-free survival (PFS) and overall survival. METHODS: A literature search on Web of Science and PubMed was performed for literature in English published from 1963 to September 2018. Detailed information including demographics, clinical characteristics, treatments, critical events, and time to events for survival analysis were extracted from the included articles. RESULTS: A total of 36 cases from published articles were selected for analysis. Univariate analysis showed that age (<31 years or ≥31 years), grade (pure low grade/low and high grade) and glioma type (astrocytoma/oligodendroglioma) had a significant relationship with PFS. Cox regression analysis showed that tumor grade was an independent prognostic factor for PFS. No factors correlated with overall survival. CONCLUSIONS: This integrative analysis of MLGGs patients revealed that age younger than 31 years, pure MLGG, and oligodendroglioma were significantly associated with improved PFS, and pure MLGGs was an independent prognostic factors for PFS. SN - 1878-8769 UR - https://www.unboundmedicine.com/medline/citation/31605855/An_Integrative_Survival_Analysis_for_Multicentric_Low-grade_Glioma L2 - https://linkinghub.elsevier.com/retrieve/pii/S1878-8750(19)32616-6 DB - PRIME DP - Unbound Medicine ER -