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Susceptibility evolution to antibiotics of Enterobacter cloacae, Morganella morganii, Klebsiella aerogenes and Citrobacter freundii involved in urinary tract infections: an 11-year epidemiological surveillance study.

Abstract

INTRODUCTION

The objective of this study was to analyse the susceptibility to antibiotic of Citrobacter freundii, Klebsiella aerogenes, Enterobacter cloacae, Serratia marcescens, Providencia stuartii and Morganella morganii (CESPM group), detected in urine cultures.

METHODS

Between 2006 and 2016 we analyzed CESPM group Enterobacteria isolated from urine cultures from both primary health-care centers and Hospital Virgen de las Nieves (Granada). We studied the susceptibility to aminoglycosides, fosfomycin, nitrofurantoin, quinolones, piperacillin/tazobactam, cefepime, imipenem and trimethoprim/sulfamethoxazole following CLSI interpretation criteria.

RESULTS

A total of 736 isolates were studied: 30.57% E. cloacae, 23.50% M. morganii, 20.38% K. aerogenes, 10.32% C. freundii, 8.83% S. marcescens and 6.38% P. stuartii. A significant decrease in the antibiotic susceptibility was observed. Gentamicin, ciprofloxacin, imipenem and cefepime showed susceptibility over 80%.

CONCLUSIONS

E. cloacae, M. morganii and K. aerogenes were the most common isolates. Cefepime and imipenem are still a good empiric therapeutic alternative given its activity in vitro.

Authors+Show Affiliations

Departamento de Microbiología, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Sanitaria-Granada, Granada, España.Departamento de Microbiología, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Sanitaria-Granada, Granada, España.Unidad de Medicina de Familia, Centro de Salud San Fernando, Badajoz, España.Unidad de Metodología de la Investigación y Bioestadística, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Sanitaria-Granada, Granada, España.Departamento de Microbiología, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Sanitaria-Granada, Granada, España.Departamento de Microbiología, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Sanitaria-Granada, Granada, España; Departamento de Microbiología, Facultad de Medicina, Universidad de Granada, Instituto de Investigación Sanitaria-Granada, Granada, España. Electronic address: josegf@go.ugr.es.

Pub Type(s)

Journal Article

Language

eng spa

PubMed ID

31606242

Citation

Jiménez-Guerra, Gemma, et al. "Susceptibility Evolution to Antibiotics of Enterobacter Cloacae, Morganella Morganii, Klebsiella Aerogenes and Citrobacter Freundii Involved in Urinary Tract Infections: an 11-year Epidemiological Surveillance Study." Enfermedades Infecciosas Y Microbiologia Clinica, 2019.
Jiménez-Guerra G, Borrego-Jiménez J, Gutiérrez-Soto B, et al. Susceptibility evolution to antibiotics of Enterobacter cloacae, Morganella morganii, Klebsiella aerogenes and Citrobacter freundii involved in urinary tract infections: an 11-year epidemiological surveillance study. Enferm Infecc Microbiol Clin. 2019.
Jiménez-Guerra, G., Borrego-Jiménez, J., Gutiérrez-Soto, B., Expósito-Ruiz, M., Navarro-Marí, J. M., & Gutiérrez-Fernández, J. (2019). Susceptibility evolution to antibiotics of Enterobacter cloacae, Morganella morganii, Klebsiella aerogenes and Citrobacter freundii involved in urinary tract infections: an 11-year epidemiological surveillance study. Enfermedades Infecciosas Y Microbiologia Clinica, doi:10.1016/j.eimc.2019.07.010.
Jiménez-Guerra G, et al. Susceptibility Evolution to Antibiotics of Enterobacter Cloacae, Morganella Morganii, Klebsiella Aerogenes and Citrobacter Freundii Involved in Urinary Tract Infections: an 11-year Epidemiological Surveillance Study. Enferm Infecc Microbiol Clin. 2019 Oct 9; PubMed PMID: 31606242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Susceptibility evolution to antibiotics of Enterobacter cloacae, Morganella morganii, Klebsiella aerogenes and Citrobacter freundii involved in urinary tract infections: an 11-year epidemiological surveillance study. AU - Jiménez-Guerra,Gemma, AU - Borrego-Jiménez,Jaime, AU - Gutiérrez-Soto,Blanca, AU - Expósito-Ruiz,Manuela, AU - Navarro-Marí,José María, AU - Gutiérrez-Fernández,José, Y1 - 2019/10/09/ PY - 2019/04/19/received PY - 2019/07/15/revised PY - 2019/07/19/accepted PY - 2019/10/14/entrez PY - 2019/10/14/pubmed PY - 2019/10/14/medline KW - AmpC β-lactamases KW - Enterobacteriaceae KW - Infección del tracto urinario KW - Urinary tract infections KW - β-lactamasas AmpC JF - Enfermedades infecciosas y microbiologia clinica JO - Enferm. Infecc. Microbiol. Clin. N2 - INTRODUCTION: The objective of this study was to analyse the susceptibility to antibiotic of Citrobacter freundii, Klebsiella aerogenes, Enterobacter cloacae, Serratia marcescens, Providencia stuartii and Morganella morganii (CESPM group), detected in urine cultures. METHODS: Between 2006 and 2016 we analyzed CESPM group Enterobacteria isolated from urine cultures from both primary health-care centers and Hospital Virgen de las Nieves (Granada). We studied the susceptibility to aminoglycosides, fosfomycin, nitrofurantoin, quinolones, piperacillin/tazobactam, cefepime, imipenem and trimethoprim/sulfamethoxazole following CLSI interpretation criteria. RESULTS: A total of 736 isolates were studied: 30.57% E. cloacae, 23.50% M. morganii, 20.38% K. aerogenes, 10.32% C. freundii, 8.83% S. marcescens and 6.38% P. stuartii. A significant decrease in the antibiotic susceptibility was observed. Gentamicin, ciprofloxacin, imipenem and cefepime showed susceptibility over 80%. CONCLUSIONS: E. cloacae, M. morganii and K. aerogenes were the most common isolates. Cefepime and imipenem are still a good empiric therapeutic alternative given its activity in vitro. SN - 1578-1852 UR - https://www.unboundmedicine.com/medline/citation/31606242/Susceptibility_evolution_to_antibiotics_of_Enterobacter_cloacae,_Morganella_morganii,_Klebsiella_aerogenes_and_Citrobacter_freundii_involved_in_urinary_tract_infections:_an_11-year_epidemiological_surveillance_study L2 - https://linkinghub.elsevier.com/retrieve/pii/S0213-005X(19)30221-6 DB - PRIME DP - Unbound Medicine ER -