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[Comparison of the mismatch repair deficiency of colorectal cancers between African and European cohorts].
Ann Pathol 2019AP

Abstract

INTRODUCTION

According to European and American series, up to 20% of colorectal cancers are characterised by instability at microsatellites sites. MMR deficient colorectal cancers are predominantly found in the right colon. Although an increasing rate of colorectal cancer has been observed in many low-income countries including in West-Africa, data on epidemiology and biology of colorectal cancer in native Africans from this region are scarce.

MATERIALS AND METHODS

We aimed to study the incidence of MMR deficiency in Côte d'Ivoire and to compare the data with those from a tertiary center in Belgium. Immunohistochemistry for MLH1, MSH2, MSH6 and PMS2 was performed on paraffin-embedded tissue samples from 83 colorectal cancers (46% males) operated in Abidjan and from 343 colorectal cancers (53% males) from Brussels.

RESULTS

Colorectal cancer was occuring at a younger age in Côte d'Ivoire compared to Belgium (median age: 53 versus 66). MMR deficiency was detected in 11,7% of Belgian cases and in 13,3% of Ivorian cases. Whereas MMR deficient cancers in Brussels were mainly found in women (24/40 i.e. 60%), in Abidjan only 3/11 (27%) were female. Moreover, the predominant location of MMR deficient tumours was different between both series: in Brussels, mainly located in the right colon (24/40 i.e. 60%) whereas in Abidjan predominantly (10/11 i.e. 91%) in the left colon. In Brussels we observed in the majority of cases (67,5%) loss of expression of MLH1 and PMS2, in Abidjan loss of expression of MSH2 and MSH6 (54,5%).

CONCLUSIONS

Our pilot study reveals differences in presentation of MMR deficient colorectal cancer between the two geographic regions suggesting differences in epidemiology and biology of colorectal cancer in native Africans.

Authors+Show Affiliations

Service d'anatomie pathologique de l'hôpital Erasme (ULB), route de Lennik 808, 1070 Bruxelles, Belgique.Service d'anatomie pathologique du CHU de Cocody, boulevard de l'Université, Abidjan, Côte d'Ivoire.Service d'anatomie pathologique de l'hôpital Erasme (ULB), route de Lennik 808, 1070 Bruxelles, Belgique.Institut Jules Bordet (ULB), rue Héger-Bordet 1, 1000 Bruxelles, Belgique. Electronic address: pieter.demetter@bordet.be.

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

31606263

Citation

Bienfait, Lucie, et al. "[Comparison of the Mismatch Repair Deficiency of Colorectal Cancers Between African and European Cohorts]." Annales De Pathologie, 2019.
Bienfait L, Doukoure B, Verset L, et al. [Comparison of the mismatch repair deficiency of colorectal cancers between African and European cohorts]. Ann Pathol. 2019.
Bienfait, L., Doukoure, B., Verset, L., & Demetter, P. (2019). [Comparison of the mismatch repair deficiency of colorectal cancers between African and European cohorts]. Annales De Pathologie, doi:10.1016/j.annpat.2019.08.002.
Bienfait L, et al. [Comparison of the Mismatch Repair Deficiency of Colorectal Cancers Between African and European Cohorts]. Ann Pathol. 2019 Oct 9; PubMed PMID: 31606263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparison of the mismatch repair deficiency of colorectal cancers between African and European cohorts]. AU - Bienfait,Lucie, AU - Doukoure,Brahima, AU - Verset,Laurine, AU - Demetter,Pieter, Y1 - 2019/10/09/ PY - 2018/12/31/received PY - 2019/08/09/revised PY - 2019/08/28/accepted PY - 2019/10/14/entrez PY - 2019/10/14/pubmed PY - 2019/10/14/medline KW - Africa KW - Afrique KW - Cancer KW - Colorectal KW - Immunohistochemistry KW - Immunohistochimie KW - Instabilité microsatellitaire KW - Microsatellite instability JF - Annales de pathologie JO - Ann Pathol N2 - INTRODUCTION: According to European and American series, up to 20% of colorectal cancers are characterised by instability at microsatellites sites. MMR deficient colorectal cancers are predominantly found in the right colon. Although an increasing rate of colorectal cancer has been observed in many low-income countries including in West-Africa, data on epidemiology and biology of colorectal cancer in native Africans from this region are scarce. MATERIALS AND METHODS: We aimed to study the incidence of MMR deficiency in Côte d'Ivoire and to compare the data with those from a tertiary center in Belgium. Immunohistochemistry for MLH1, MSH2, MSH6 and PMS2 was performed on paraffin-embedded tissue samples from 83 colorectal cancers (46% males) operated in Abidjan and from 343 colorectal cancers (53% males) from Brussels. RESULTS: Colorectal cancer was occuring at a younger age in Côte d'Ivoire compared to Belgium (median age: 53 versus 66). MMR deficiency was detected in 11,7% of Belgian cases and in 13,3% of Ivorian cases. Whereas MMR deficient cancers in Brussels were mainly found in women (24/40 i.e. 60%), in Abidjan only 3/11 (27%) were female. Moreover, the predominant location of MMR deficient tumours was different between both series: in Brussels, mainly located in the right colon (24/40 i.e. 60%) whereas in Abidjan predominantly (10/11 i.e. 91%) in the left colon. In Brussels we observed in the majority of cases (67,5%) loss of expression of MLH1 and PMS2, in Abidjan loss of expression of MSH2 and MSH6 (54,5%). CONCLUSIONS: Our pilot study reveals differences in presentation of MMR deficient colorectal cancer between the two geographic regions suggesting differences in epidemiology and biology of colorectal cancer in native Africans. SN - 0242-6498 UR - https://www.unboundmedicine.com/medline/citation/31606263/[Comparison_of_the_mismatch_repair_deficiency_of_colorectal_cancers_between_African_and_European_cohorts] L2 - https://linkinghub.elsevier.com/retrieve/pii/S0242-6498(19)30150-6 DB - PRIME DP - Unbound Medicine ER -