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Intracerebroventricular injection of deltamethrin increases locomotion activity and causes spatial working memory and dopaminergic pathway impairment in rats.
Brain Res Bull. 2020 01; 154:1-8.BR

Abstract

Deltamethrin (DM) is widely used in agriculture, veterinary medicine and control of domestic pests. Epidemiological studies suggest that DM exposure is a risk factor for neurodegenerative disorders such as Parkinson's (PD) and Alzheimer diseases; however the mechanisms are elusive. In the present study we evaluated the effects of intracerebroventricular (i.c.v.) administration of DM on locomotion activity, spatial working memory and dopaminergic pathway in the rat. Middle-aged male Wistar rats received three i.c.v. injections of DM 0.5 μg, DM 5 μg or vehicle, every other day. Across the treatment, the animals were submitted to behavioral evaluation in the catalepsy test, open field test, and spontaneous alternation task. Following completion of behavioral tests, rats were perfused and their brains were processed to tyrosine hydroxylase (TH) immunohistochemistry. We observed that i.c.v. administration of DM 5 μg increased locomotion activity (open field) and caused spatial working memory impairment (spontaneous alternation task). These alterations were accompanied by reduction TH immunoreactivity in the substantia nigra pars compacta (SNpc), ventral tegmental area (VTA) and dorsal striatum. Conversely, no motor change was observed in the catalepsy test. These results indicate that i.c.v. administration of DM can cause hyperactivity and cognitive alteration which may be related to disruption of the dopaminergic pathway.

Authors+Show Affiliations

Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Laboratory of Behavioral and Evolutionary Neurobiology, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Laboratory of Behavioral and Evolutionary Neurobiology, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.Department of Health Education, Federal University of Sergipe, Lagarto, SE, Brazil.Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Laboratory of Behavioral and Evolutionary Neurobiology, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Laboratory of Behavioral and Evolutionary Neurobiology, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.Post Graduation Program in Health and Society, University of the State of Rio Grande do Norte, Mossoró, RN, Brazil; New Hope Faculty of Mossoró, RN, Brazil.Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Laboratory of Behavioral and Evolutionary Neurobiology, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil.Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Laboratory of Behavioral and Evolutionary Neurobiology, Department of Biosciences, Federal University of Sergipe, Itabaiana, SE, Brazil. Electronic address: joseronaldosantos@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31606407

Citation

Souza, Marina F., et al. "Intracerebroventricular Injection of Deltamethrin Increases Locomotion Activity and Causes Spatial Working Memory and Dopaminergic Pathway Impairment in Rats." Brain Research Bulletin, vol. 154, 2020, pp. 1-8.
Souza MF, Medeiros KAAL, Lins LCRF, et al. Intracerebroventricular injection of deltamethrin increases locomotion activity and causes spatial working memory and dopaminergic pathway impairment in rats. Brain Res Bull. 2020;154:1-8.
Souza, M. F., Medeiros, K. A. A. L., Lins, L. C. R. F., Bispo, J. M. M., Gois, A. M., Freire, M. A. M., Marchioro, M., & Santos, J. R. (2020). Intracerebroventricular injection of deltamethrin increases locomotion activity and causes spatial working memory and dopaminergic pathway impairment in rats. Brain Research Bulletin, 154, 1-8. https://doi.org/10.1016/j.brainresbull.2019.10.002
Souza MF, et al. Intracerebroventricular Injection of Deltamethrin Increases Locomotion Activity and Causes Spatial Working Memory and Dopaminergic Pathway Impairment in Rats. Brain Res Bull. 2020;154:1-8. PubMed PMID: 31606407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intracerebroventricular injection of deltamethrin increases locomotion activity and causes spatial working memory and dopaminergic pathway impairment in rats. AU - Souza,Marina F, AU - Medeiros,Katty Anne A L, AU - Lins,Lívia C R F, AU - Bispo,José M M, AU - Gois,Auderlan M, AU - Freire,Marco Aurelio M, AU - Marchioro,Murilo, AU - Santos,José R, Y1 - 2019/10/10/ PY - 2019/03/19/received PY - 2019/09/18/revised PY - 2019/10/05/accepted PY - 2019/10/14/pubmed PY - 2021/6/8/medline PY - 2019/10/14/entrez KW - Cognition KW - Dopamine KW - Neurodegenerative disorder KW - Pesticide KW - Pyrethroid SP - 1 EP - 8 JF - Brain research bulletin JO - Brain Res Bull VL - 154 N2 - Deltamethrin (DM) is widely used in agriculture, veterinary medicine and control of domestic pests. Epidemiological studies suggest that DM exposure is a risk factor for neurodegenerative disorders such as Parkinson's (PD) and Alzheimer diseases; however the mechanisms are elusive. In the present study we evaluated the effects of intracerebroventricular (i.c.v.) administration of DM on locomotion activity, spatial working memory and dopaminergic pathway in the rat. Middle-aged male Wistar rats received three i.c.v. injections of DM 0.5 μg, DM 5 μg or vehicle, every other day. Across the treatment, the animals were submitted to behavioral evaluation in the catalepsy test, open field test, and spontaneous alternation task. Following completion of behavioral tests, rats were perfused and their brains were processed to tyrosine hydroxylase (TH) immunohistochemistry. We observed that i.c.v. administration of DM 5 μg increased locomotion activity (open field) and caused spatial working memory impairment (spontaneous alternation task). These alterations were accompanied by reduction TH immunoreactivity in the substantia nigra pars compacta (SNpc), ventral tegmental area (VTA) and dorsal striatum. Conversely, no motor change was observed in the catalepsy test. These results indicate that i.c.v. administration of DM can cause hyperactivity and cognitive alteration which may be related to disruption of the dopaminergic pathway. SN - 1873-2747 UR - https://www.unboundmedicine.com/medline/citation/31606407/Intracerebroventricular_injection_of_deltamethrin_increases_locomotion_activity_and_causes_spatial_working_memory_and_dopaminergic_pathway_impairment_in_rats_ DB - PRIME DP - Unbound Medicine ER -