Tags

Type your tag names separated by a space and hit enter

Deciphering host immunity to malaria using systems immunology.

Abstract

A century of conceptual and technological advances in infectious disease research has changed the face of medicine. However, there remains a lack of effective interventions and a poor understanding of host immunity to the most significant and complex pathogens, including malaria. The development of successful interventions against such intractable diseases requires a comprehensive understanding of host-pathogen immune responses. A major advance of the past decade has been a paradigm switch in thinking from the contemporary reductionist (gene-by-gene or protein-by-protein) view to a more holistic (whole organism) view. Also, a recognition that host-pathogen immunity is composed of complex, dynamic interactions of cellular and molecular components and networks that cannot be represented by any individual component in isolation. Systems immunology integrates the field of immunology with omics technologies and computational sciences to comprehensively interrogate the immune response at a systems level. Herein, we describe the system immunology toolkit and report recent studies deploying systems-level approaches in the context of natural exposure to malaria or controlled human malaria infection. We contribute our perspective on the potential of systems immunity for the rational design and development of effective interventions to improve global public health.

Authors+Show Affiliations

Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Qld, Australia.Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Qld, Australia.Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Qld, Australia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31608461

Citation

Loiseau, Claire, et al. "Deciphering Host Immunity to Malaria Using Systems Immunology." Immunological Reviews, 2019.
Loiseau C, Cooper MM, Doolan DL. Deciphering host immunity to malaria using systems immunology. Immunol Rev. 2019.
Loiseau, C., Cooper, M. M., & Doolan, D. L. (2019). Deciphering host immunity to malaria using systems immunology. Immunological Reviews, doi:10.1111/imr.12814.
Loiseau C, Cooper MM, Doolan DL. Deciphering Host Immunity to Malaria Using Systems Immunology. Immunol Rev. 2019 Oct 14; PubMed PMID: 31608461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deciphering host immunity to malaria using systems immunology. AU - Loiseau,Claire, AU - Cooper,Martha M, AU - Doolan,Denise L, Y1 - 2019/10/14/ PY - 2019/09/15/received PY - 2019/09/18/revised PY - 2019/09/20/accepted PY - 2019/10/15/pubmed PY - 2019/10/15/medline PY - 2019/10/15/entrez KW - Plasmodium KW - controlled infection KW - experimental infection KW - immunity KW - malaria KW - naturally acquired immunity KW - omics KW - systems immunology JF - Immunological reviews JO - Immunol. Rev. N2 - A century of conceptual and technological advances in infectious disease research has changed the face of medicine. However, there remains a lack of effective interventions and a poor understanding of host immunity to the most significant and complex pathogens, including malaria. The development of successful interventions against such intractable diseases requires a comprehensive understanding of host-pathogen immune responses. A major advance of the past decade has been a paradigm switch in thinking from the contemporary reductionist (gene-by-gene or protein-by-protein) view to a more holistic (whole organism) view. Also, a recognition that host-pathogen immunity is composed of complex, dynamic interactions of cellular and molecular components and networks that cannot be represented by any individual component in isolation. Systems immunology integrates the field of immunology with omics technologies and computational sciences to comprehensively interrogate the immune response at a systems level. Herein, we describe the system immunology toolkit and report recent studies deploying systems-level approaches in the context of natural exposure to malaria or controlled human malaria infection. We contribute our perspective on the potential of systems immunity for the rational design and development of effective interventions to improve global public health. SN - 1600-065X UR - https://www.unboundmedicine.com/medline/citation/31608461/Deciphering_host_immunity_to_malaria_using_systems_immunology L2 - https://doi.org/10.1111/imr.12814 DB - PRIME DP - Unbound Medicine ER -