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Importance of Surface Coating to Accumulation Dynamics and Acute Toxicity of Copper Nanomaterials and Dissolved Copper in Daphnia magna.
Environ Toxicol Chem. 2020 02; 39(2):287-299.ET

Abstract

We evaluated the effect of copper oxide nanomaterials (CuO NMs), uncoated and with 3 different surface coatings (carboxylated, pegylated, and ammonia groups), on acute toxicity and accumulation dynamics in Daphnia magna. With the use of biodynamic modelling, biosorption and elimination rate constants were determined for D. magna following waterborne exposure to dissolved Cu and CuO NMs. The relationship between modeled parameters and acute toxicity endpoints was evaluated to investigate whether accumulation dynamics parameters could be used as a predictor of acute toxicity. The Langmuir equation was used to characterize the biosorption dynamics of Cu NMs and Cu chloride, used as dissolved Cu control. Uptake rates showed the following NM rankings: pristine-CuO > NH3 -CuO > aqueous Cu > polyethylene glycol (PEG)-CuO > COOH-CuO. To determine Cu elimination by D. magna, a one-compartment model was used. Different elimination rate constants were estimated for each chemical substance tested. Those that were easily biosorbed were also easily removed from organisms. Biosorption and depuration properties of NMs were correlated with zeta potential values and diameters of NM agglomerates in the suspensions. No link was found between biosorption and toxicity. Waterborne exposures to more difficult-to-biosorb CuO NMs were more likely to induce adverse effects than those that biosorbed easily. It is proposed that some physicochemical properties of NMs in media, including zeta potential and agglomerate diameter, can lead to higher biosorption but do not necessarily affect toxicity. The mode of interaction of the NMs with the organism seems to be complex and to depend on chemical speciation and physicochemical properties of the NMs inside an organism. Moreover, our findings highlight that coating type affects the biosorption dynamics, depuration kinetics, and dissolution rate of NMs in media. Environ Toxicol Chem 2020;39:287-299. © 2019 SETAC.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Gajda-Meissner Z
School of Energy, Geoscience, Infrastructure and Society, Institute of Life and Earth Sciences, Centre for Marine Biodiversity & Biotechnology, Heriot-Watt University, Edinburgh, Scotland.
Matyja K
Faculty of Chemistry, Division of Bioprocess and Biomedical Engineering, Wroclaw University of Science and Technology, Wrocław, Poland.
Brown DM
School of School of Engineering and Physical Sciences, Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh, Scotland.
Hartl MGJ
School of Energy, Geoscience, Infrastructure and Society, Institute of Life and Earth Sciences, Centre for Marine Biodiversity & Biotechnology, Heriot-Watt University, Edinburgh, Scotland.
Fernandes TF
School of Energy, Geoscience, Infrastructure and Society, Institute of Life and Earth Sciences, Centre for Marine Biodiversity & Biotechnology, Heriot-Watt University, Edinburgh, Scotland.

MeSH

AnimalsBioaccumulationCopperDaphniaModels, BiologicalNanostructuresSolubilitySurface PropertiesWaterWater Pollutants, Chemical

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31610609

Citation

Gajda-Meissner, Zuzanna, et al. "Importance of Surface Coating to Accumulation Dynamics and Acute Toxicity of Copper Nanomaterials and Dissolved Copper in Daphnia Magna." Environmental Toxicology and Chemistry, vol. 39, no. 2, 2020, pp. 287-299.
Gajda-Meissner Z, Matyja K, Brown DM, et al. Importance of Surface Coating to Accumulation Dynamics and Acute Toxicity of Copper Nanomaterials and Dissolved Copper in Daphnia magna. Environ Toxicol Chem. 2020;39(2):287-299.
Gajda-Meissner, Z., Matyja, K., Brown, D. M., Hartl, M. G. J., & Fernandes, T. F. (2020). Importance of Surface Coating to Accumulation Dynamics and Acute Toxicity of Copper Nanomaterials and Dissolved Copper in Daphnia magna. Environmental Toxicology and Chemistry, 39(2), 287-299. https://doi.org/10.1002/etc.4617
Gajda-Meissner Z, et al. Importance of Surface Coating to Accumulation Dynamics and Acute Toxicity of Copper Nanomaterials and Dissolved Copper in Daphnia Magna. Environ Toxicol Chem. 2020;39(2):287-299. PubMed PMID: 31610609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Importance of Surface Coating to Accumulation Dynamics and Acute Toxicity of Copper Nanomaterials and Dissolved Copper in Daphnia magna. AU - Gajda-Meissner,Zuzanna, AU - Matyja,Konrad, AU - Brown,David M, AU - Hartl,Mark G J, AU - Fernandes,Teresa F, Y1 - 2020/01/09/ PY - 2019/02/15/received PY - 2019/04/05/revised PY - 2019/10/10/accepted PY - 2019/10/15/pubmed PY - 2020/8/18/medline PY - 2019/10/15/entrez KW - Copper KW - Dose-response modeling KW - Metal uptake SP - 287 EP - 299 JF - Environmental toxicology and chemistry JO - Environ Toxicol Chem VL - 39 IS - 2 N2 - We evaluated the effect of copper oxide nanomaterials (CuO NMs), uncoated and with 3 different surface coatings (carboxylated, pegylated, and ammonia groups), on acute toxicity and accumulation dynamics in Daphnia magna. With the use of biodynamic modelling, biosorption and elimination rate constants were determined for D. magna following waterborne exposure to dissolved Cu and CuO NMs. The relationship between modeled parameters and acute toxicity endpoints was evaluated to investigate whether accumulation dynamics parameters could be used as a predictor of acute toxicity. The Langmuir equation was used to characterize the biosorption dynamics of Cu NMs and Cu chloride, used as dissolved Cu control. Uptake rates showed the following NM rankings: pristine-CuO > NH3 -CuO > aqueous Cu > polyethylene glycol (PEG)-CuO > COOH-CuO. To determine Cu elimination by D. magna, a one-compartment model was used. Different elimination rate constants were estimated for each chemical substance tested. Those that were easily biosorbed were also easily removed from organisms. Biosorption and depuration properties of NMs were correlated with zeta potential values and diameters of NM agglomerates in the suspensions. No link was found between biosorption and toxicity. Waterborne exposures to more difficult-to-biosorb CuO NMs were more likely to induce adverse effects than those that biosorbed easily. It is proposed that some physicochemical properties of NMs in media, including zeta potential and agglomerate diameter, can lead to higher biosorption but do not necessarily affect toxicity. The mode of interaction of the NMs with the organism seems to be complex and to depend on chemical speciation and physicochemical properties of the NMs inside an organism. Moreover, our findings highlight that coating type affects the biosorption dynamics, depuration kinetics, and dissolution rate of NMs in media. Environ Toxicol Chem 2020;39:287-299. © 2019 SETAC. SN - 1552-8618 UR - https://www.unboundmedicine.com/medline/citation/31610609/Importance_of_Surface_Coating_to_Accumulation_Dynamics_and_Acute_Toxicity_of_Copper_Nanomaterials_and_Dissolved_Copper_in_Daphnia_magna_ DB - PRIME DP - Unbound Medicine ER -