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Parental occupational exposure to diesel engine exhaust in relation to childhood leukaemia and central nervous system cancers: a register-based nested case-control study in Denmark 1968-2016.
Occup Environ Med 2019; 76(11):809-817OE

Abstract

OBJECTIVES

Using nationwide register data, we investigated the association between maternal and paternal perinatal employment in industries with exposure to diesel engine exhaust and risk of leukaemia and central nervous system (CNS) cancers, including certain subtypes.

METHODS

Children aged≤19 years and diagnosed with childhood cancer from 1968 to 2016 were identified in the Danish Cancer Registry and 25 randomly selected cancer-free controls per case were matched by age and sex. Parents were identified in the Danish Civil Registration System and employment histories were retrieved from a nationwide mandatory pension fund. The probability of exposure to diesel engine exhaust was assessed using a validated job exposure matrix. Conditional logistic regression was used for estimation of ORs, including their 95% CIs.

RESULTS

Maternal employment in industries with diesel engine exhaust exposure was associated with an increased risk of CNS cancers (OR 1.31, 95% CI 0.99 to 1.74) and of astrocytoma (OR 1.49, 95% CI 1.04 to 2.14) in offspring. The highest OR for these cancers were seen for mothers with highest probability of exposure to diesel engine exhaust. For fathers, ORs for cancers under study were close to one. No increased risks of leukaemias were found for either mothers or fathers employed in diesel industries.

CONCLUSIONS

Risks were increased for CNS and astrocytoma for maternal employment in industries with diesel engine exhaust.

Authors+Show Affiliations

Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark julvol@cancer.dk.Department of Epidemiology, University of California, Los Angeles, California, USA.Department of Paediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.Institute of Cancer Epidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31611302

Citation

Volk, Julie, et al. "Parental Occupational Exposure to Diesel Engine Exhaust in Relation to Childhood Leukaemia and Central Nervous System Cancers: a Register-based Nested Case-control Study in Denmark 1968-2016." Occupational and Environmental Medicine, vol. 76, no. 11, 2019, pp. 809-817.
Volk J, Heck JE, Schmiegelow K, et al. Parental occupational exposure to diesel engine exhaust in relation to childhood leukaemia and central nervous system cancers: a register-based nested case-control study in Denmark 1968-2016. Occup Environ Med. 2019;76(11):809-817.
Volk, J., Heck, J. E., Schmiegelow, K., & Hansen, J. (2019). Parental occupational exposure to diesel engine exhaust in relation to childhood leukaemia and central nervous system cancers: a register-based nested case-control study in Denmark 1968-2016. Occupational and Environmental Medicine, 76(11), pp. 809-817. doi:10.1136/oemed-2019-105847.
Volk J, et al. Parental Occupational Exposure to Diesel Engine Exhaust in Relation to Childhood Leukaemia and Central Nervous System Cancers: a Register-based Nested Case-control Study in Denmark 1968-2016. Occup Environ Med. 2019;76(11):809-817. PubMed PMID: 31611302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental occupational exposure to diesel engine exhaust in relation to childhood leukaemia and central nervous system cancers: a register-based nested case-control study in Denmark 1968-2016. AU - Volk,Julie, AU - Heck,Julia E, AU - Schmiegelow,Kjeld, AU - Hansen,Johnni, PY - 2019/03/28/received PY - 2019/07/31/revised PY - 2019/08/25/accepted PY - 2019/10/16/entrez KW - childhood cancer KW - diesel engine exhaust KW - job-exposure matrix KW - parental occupational exposure KW - register-based study SP - 809 EP - 817 JF - Occupational and environmental medicine JO - Occup Environ Med VL - 76 IS - 11 N2 - OBJECTIVES: Using nationwide register data, we investigated the association between maternal and paternal perinatal employment in industries with exposure to diesel engine exhaust and risk of leukaemia and central nervous system (CNS) cancers, including certain subtypes. METHODS: Children aged≤19 years and diagnosed with childhood cancer from 1968 to 2016 were identified in the Danish Cancer Registry and 25 randomly selected cancer-free controls per case were matched by age and sex. Parents were identified in the Danish Civil Registration System and employment histories were retrieved from a nationwide mandatory pension fund. The probability of exposure to diesel engine exhaust was assessed using a validated job exposure matrix. Conditional logistic regression was used for estimation of ORs, including their 95% CIs. RESULTS: Maternal employment in industries with diesel engine exhaust exposure was associated with an increased risk of CNS cancers (OR 1.31, 95% CI 0.99 to 1.74) and of astrocytoma (OR 1.49, 95% CI 1.04 to 2.14) in offspring. The highest OR for these cancers were seen for mothers with highest probability of exposure to diesel engine exhaust. For fathers, ORs for cancers under study were close to one. No increased risks of leukaemias were found for either mothers or fathers employed in diesel industries. CONCLUSIONS: Risks were increased for CNS and astrocytoma for maternal employment in industries with diesel engine exhaust. SN - 1470-7926 UR - https://www.unboundmedicine.com/medline/citation/31611302/Parental_occupational_exposure_to_diesel_engine_exhaust_in_relation_to_childhood_leukaemia_and_central_nervous_system_cancers:_a_register-based_nested_case-control_study_in_Denmark_1968-2016 L2 - http://oem.bmj.com/cgi/pmidlookup?view=long&pmid=31611302 DB - PRIME DP - Unbound Medicine ER -