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Clot Structure and Implications for Bleeding and Thrombosis.

Abstract

The formation of a fibrin clot matrix plays a critical role in promoting hemostasis and wound healing. Fibrin dynamics can become disadvantageous in the formation of aberrant thrombus development. Structural characteristics of clots, such as fiber diameter, clot density, stiffness, or permeability, can determine overall clot integrity and functional characteristics that have implications on coagulation and fibrinolysis. This review examines known factors that contribute to changes in clot structure and the presence of structural clot changes in various disease states. These insights provide valuable information in forming therapeutic strategies for disease states where alterations in clot structure are observed. Additionally, the implications of structural changes in clot networks on bleeding and thrombus development in terms of disease states and clinical outcomes are also examined in this review.

Authors+Show Affiliations

Joint Department of Biomedical Engineering, North Carolina State University and University of North Carolina at Chapel Hill, Raleigh, North Carolina. Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina.Joint Department of Biomedical Engineering, North Carolina State University and University of North Carolina at Chapel Hill, Raleigh, North Carolina. Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31614389

Citation

Mihalko, Emily, and Ashley C. Brown. "Clot Structure and Implications for Bleeding and Thrombosis." Seminars in Thrombosis and Hemostasis, 2019.
Mihalko E, Brown AC. Clot Structure and Implications for Bleeding and Thrombosis. Semin Thromb Hemost. 2019.
Mihalko, E., & Brown, A. C. (2019). Clot Structure and Implications for Bleeding and Thrombosis. Seminars in Thrombosis and Hemostasis, doi:10.1055/s-0039-1696944.
Mihalko E, Brown AC. Clot Structure and Implications for Bleeding and Thrombosis. Semin Thromb Hemost. 2019 Oct 15; PubMed PMID: 31614389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clot Structure and Implications for Bleeding and Thrombosis. AU - Mihalko,Emily, AU - Brown,Ashley C, Y1 - 2019/10/15/ PY - 2019/10/16/entrez PY - 2019/10/16/pubmed PY - 2019/10/16/medline JF - Seminars in thrombosis and hemostasis JO - Semin. Thromb. Hemost. N2 - The formation of a fibrin clot matrix plays a critical role in promoting hemostasis and wound healing. Fibrin dynamics can become disadvantageous in the formation of aberrant thrombus development. Structural characteristics of clots, such as fiber diameter, clot density, stiffness, or permeability, can determine overall clot integrity and functional characteristics that have implications on coagulation and fibrinolysis. This review examines known factors that contribute to changes in clot structure and the presence of structural clot changes in various disease states. These insights provide valuable information in forming therapeutic strategies for disease states where alterations in clot structure are observed. Additionally, the implications of structural changes in clot networks on bleeding and thrombus development in terms of disease states and clinical outcomes are also examined in this review. SN - 1098-9064 UR - https://www.unboundmedicine.com/medline/citation/31614389/Clot_Structure_and_Implications_for_Bleeding_and_Thrombosis L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0039-1696944 DB - PRIME DP - Unbound Medicine ER -