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Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration.
Cells 2019; 8(10)C

Abstract

Extracellular vesicles (EVs) are membranous vesicles containing active proteins, lipids, and different types of genetic material such as miRNAs, mRNAs, and DNAs related to the characteristics of the originating cell. They possess a distinctive capacity to communicate over long distances. EVs have been involved in the modulation of several pathophysiological conditions and, more importantly, stem cell-derived EVs appear as a new promising therapeutic option. In fact, several reports provide convincing evidence of the regenerative potential of EVs released by stem cells and, in particular, mesenchymal stromal cells (MSCs) in different kidney injury models. Described mechanisms involve the reprogramming of injured cells, cell proliferation and angiogenesis, and inhibition of cell apoptosis and inflammation. Besides, the therapeutic use of MSC-EVs in clinical trials is under investigation. This review will focus on MSC-EV applications in preclinical models of acute and chronic renal damage including recent data on their use in kidney transplant conditioning. Moreover, ongoing clinical trials are described. Finally, new strategies to broaden and enhance EV therapeutic efficacy by engineering are discussed.

Authors+Show Affiliations

Department of Medical Sciences, University of Turin, via Nizza 52, 10126 Torino, Italy. cristina.grange@unito.it.Department of Molecular Biotechnology and Health Sciences, University of Turin, via Nizza 52, 10126 Torino, Italy. renata.skovronova@unito.it.Department of Molecular Biotechnology and Health Sciences, University of Turin, via Nizza 52, 10126 Torino, Italy. federica.marabese@edu.unito.it. Maria Pia Hospital, 10132 Turin, Italy. federica.marabese@edu.unito.it.Department of Molecular Biotechnology and Health Sciences, University of Turin, via Nizza 52, 10126 Torino, Italy. benedetta.bussolati@unito.it.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31614642

Citation

Grange, Cristina, et al. "Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration." Cells, vol. 8, no. 10, 2019.
Grange C, Skovronova R, Marabese F, et al. Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration. Cells. 2019;8(10).
Grange, C., Skovronova, R., Marabese, F., & Bussolati, B. (2019). Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration. Cells, 8(10), doi:10.3390/cells8101240.
Grange C, et al. Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration. Cells. 2019 Oct 11;8(10) PubMed PMID: 31614642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration. AU - Grange,Cristina, AU - Skovronova,Renata, AU - Marabese,Federica, AU - Bussolati,Benedetta, Y1 - 2019/10/11/ PY - 2019/09/20/received PY - 2019/10/10/revised PY - 2019/10/11/accepted PY - 2019/10/17/entrez PY - 2019/10/17/pubmed PY - 2019/10/17/medline KW - AKI KW - CKD KW - exosomes KW - regenerative medicine KW - renal injury JF - Cells JO - Cells VL - 8 IS - 10 N2 - Extracellular vesicles (EVs) are membranous vesicles containing active proteins, lipids, and different types of genetic material such as miRNAs, mRNAs, and DNAs related to the characteristics of the originating cell. They possess a distinctive capacity to communicate over long distances. EVs have been involved in the modulation of several pathophysiological conditions and, more importantly, stem cell-derived EVs appear as a new promising therapeutic option. In fact, several reports provide convincing evidence of the regenerative potential of EVs released by stem cells and, in particular, mesenchymal stromal cells (MSCs) in different kidney injury models. Described mechanisms involve the reprogramming of injured cells, cell proliferation and angiogenesis, and inhibition of cell apoptosis and inflammation. Besides, the therapeutic use of MSC-EVs in clinical trials is under investigation. This review will focus on MSC-EV applications in preclinical models of acute and chronic renal damage including recent data on their use in kidney transplant conditioning. Moreover, ongoing clinical trials are described. Finally, new strategies to broaden and enhance EV therapeutic efficacy by engineering are discussed. SN - 2073-4409 UR - https://www.unboundmedicine.com/medline/citation/31614642/Stem_Cell-Derived_Extracellular_Vesicles_and_Kidney_Regeneration L2 - http://www.mdpi.com/resolver?pii=cells8101240 DB - PRIME DP - Unbound Medicine ER -