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The value of tocainide in the treatment of tinnitus. A double-blind controlled study.
Arch Otorhinolaryngol. 1985; 241(3):279-83.AO

Abstract

We assessed the value of tocainide in the treatment of tinnitus by performing a double-blind controlled trial in which each of 48 patients with annoying tinnitus received either tocainide HC1 900 mg/day or a placebo. Before the trial, the effect of intravenous lidocaine was evaluated in each patient so that both lidocaine and tocainide could be compared in altering tinnitus. We found that tocainide appeared to have no better effect than the placebo, whereas lidocaine suppressed tinnitus in 81% of the patients treated. The mechanisms of action of both drugs as well as their influence on tinnitus are discussed, as are the side effects of tocainide.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

3161487

Citation

Hulshof, J H., and P Vermeij. "The Value of Tocainide in the Treatment of Tinnitus. a Double-blind Controlled Study." Archives of Oto-rhino-laryngology, vol. 241, no. 3, 1985, pp. 279-83.
Hulshof JH, Vermeij P. The value of tocainide in the treatment of tinnitus. A double-blind controlled study. Arch Otorhinolaryngol. 1985;241(3):279-83.
Hulshof, J. H., & Vermeij, P. (1985). The value of tocainide in the treatment of tinnitus. A double-blind controlled study. Archives of Oto-rhino-laryngology, 241(3), 279-83.
Hulshof JH, Vermeij P. The Value of Tocainide in the Treatment of Tinnitus. a Double-blind Controlled Study. Arch Otorhinolaryngol. 1985;241(3):279-83. PubMed PMID: 3161487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The value of tocainide in the treatment of tinnitus. A double-blind controlled study. AU - Hulshof,J H, AU - Vermeij,P, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 279 EP - 83 JF - Archives of oto-rhino-laryngology JO - Arch Otorhinolaryngol VL - 241 IS - 3 N2 - We assessed the value of tocainide in the treatment of tinnitus by performing a double-blind controlled trial in which each of 48 patients with annoying tinnitus received either tocainide HC1 900 mg/day or a placebo. Before the trial, the effect of intravenous lidocaine was evaluated in each patient so that both lidocaine and tocainide could be compared in altering tinnitus. We found that tocainide appeared to have no better effect than the placebo, whereas lidocaine suppressed tinnitus in 81% of the patients treated. The mechanisms of action of both drugs as well as their influence on tinnitus are discussed, as are the side effects of tocainide. SN - 0302-9530 UR - https://www.unboundmedicine.com/medline/citation/3161487/The_value_of_tocainide_in_the_treatment_of_tinnitus__A_double_blind_controlled_study_ L2 - http://www.diseaseinfosearch.org/result/9653 DB - PRIME DP - Unbound Medicine ER -