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Acute poisoning related to the recreational use of prescription drugs: an observational study from Oslo, Norway.
BMC Emerg Med 2019; 19(1):55BE

Abstract

BACKGROUND

Recreational use of prescription drugs is widespread. We describe acute poisonings related to the recreational use of prescription drugs.

METHODS

Retrospective observational study. We retrospectively registered all patients presenting from October 2013 through March 2015 at a primary care emergency outpatient clinic in Oslo, Norway, with an acute poisoning related to recreational drug use. We registered demographic data, toxic agents taken, clinical course and treatment. From this data set we extracted the 819/2218 (36.9%) cases involving one or more prescription drugs.

RESULTS

Among the 819 included cases, 190 (23.2%) were female. Median age was 37 years. The drugs most commonly involved were benzodiazepines in 696 (85.0%) cases, methadone in 60 (7.3%), buprenorphine in 53 (6.5%), other opioids in 56 (6.8%), zopiclone/zolpidem in 26 (3.2%), and methylphenidate in 11 (1.3%). Prescription drugs were combined with other toxic agents in 659 (80.5%) cases; heroin in 351 (42.9%), ethanol in 232 (28.3%), amphetamine in 141 (17.2%), cannabis in 70 (8.5%), gamma-hydroxybutyrate (GHB) in 34 (4.2%), cocaine in 29 (3.5%), and other illegal drugs in 46 (5.6%). The patient was given naloxone in 133 (16.2%) cases, sedation in 15 (1.8%), and flumazenil in 3 (0.4%). In 157 (19.2%) cases, the patient was sent on to hospital.

CONCLUSIONS

One in three acute poisonings related to recreational drug use involved prescription drugs. Benzodiazepines were by far the most common class of drugs. Prescription drugs had mostly been taken in combination with illegal drugs or ethanol.

Authors+Show Affiliations

Faculty of Medicine, University of Oslo, Oslo, Norway. The Norwegian PSC Research Center, Oslo University Hospital, Oslo, Norway.General Practice Research Unit, University of Oslo, Oslo, Norway.Faculty of Medicine, University of Oslo, Oslo, Norway. Oslo Accident and Emergency Outpatient Clinic, Department of Emergency General Practice, City of Oslo Health Agency, Oslo, Norway.Oslo Accident and Emergency Outpatient Clinic, Department of Emergency General Practice, City of Oslo Health Agency, Oslo, Norway. o.m.vallersnes@medisin.uio.no. Department of General Practice, University of Oslo, Oslo, Norway. o.m.vallersnes@medisin.uio.no.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31615421

Citation

Grimsrud, Marit Mæhle, et al. "Acute Poisoning Related to the Recreational Use of Prescription Drugs: an Observational Study From Oslo, Norway." BMC Emergency Medicine, vol. 19, no. 1, 2019, p. 55.
Grimsrud MM, Brekke M, Syse VL, et al. Acute poisoning related to the recreational use of prescription drugs: an observational study from Oslo, Norway. BMC Emerg Med. 2019;19(1):55.
Grimsrud, M. M., Brekke, M., Syse, V. L., & Vallersnes, O. M. (2019). Acute poisoning related to the recreational use of prescription drugs: an observational study from Oslo, Norway. BMC Emergency Medicine, 19(1), p. 55. doi:10.1186/s12873-019-0271-0.
Grimsrud MM, et al. Acute Poisoning Related to the Recreational Use of Prescription Drugs: an Observational Study From Oslo, Norway. BMC Emerg Med. 2019 10 15;19(1):55. PubMed PMID: 31615421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute poisoning related to the recreational use of prescription drugs: an observational study from Oslo, Norway. AU - Grimsrud,Marit Mæhle, AU - Brekke,Mette, AU - Syse,Victoria Lykke, AU - Vallersnes,Odd Martin, Y1 - 2019/10/15/ PY - 2019/08/13/received PY - 2019/09/24/accepted PY - 2019/10/17/entrez PY - 2019/10/17/pubmed PY - 2019/10/17/medline KW - Benzodiazepines KW - Intoxication KW - Opioids KW - Poisoning KW - Prescription drugs KW - Recreational drug use SP - 55 EP - 55 JF - BMC emergency medicine JO - BMC Emerg Med VL - 19 IS - 1 N2 - BACKGROUND: Recreational use of prescription drugs is widespread. We describe acute poisonings related to the recreational use of prescription drugs. METHODS: Retrospective observational study. We retrospectively registered all patients presenting from October 2013 through March 2015 at a primary care emergency outpatient clinic in Oslo, Norway, with an acute poisoning related to recreational drug use. We registered demographic data, toxic agents taken, clinical course and treatment. From this data set we extracted the 819/2218 (36.9%) cases involving one or more prescription drugs. RESULTS: Among the 819 included cases, 190 (23.2%) were female. Median age was 37 years. The drugs most commonly involved were benzodiazepines in 696 (85.0%) cases, methadone in 60 (7.3%), buprenorphine in 53 (6.5%), other opioids in 56 (6.8%), zopiclone/zolpidem in 26 (3.2%), and methylphenidate in 11 (1.3%). Prescription drugs were combined with other toxic agents in 659 (80.5%) cases; heroin in 351 (42.9%), ethanol in 232 (28.3%), amphetamine in 141 (17.2%), cannabis in 70 (8.5%), gamma-hydroxybutyrate (GHB) in 34 (4.2%), cocaine in 29 (3.5%), and other illegal drugs in 46 (5.6%). The patient was given naloxone in 133 (16.2%) cases, sedation in 15 (1.8%), and flumazenil in 3 (0.4%). In 157 (19.2%) cases, the patient was sent on to hospital. CONCLUSIONS: One in three acute poisonings related to recreational drug use involved prescription drugs. Benzodiazepines were by far the most common class of drugs. Prescription drugs had mostly been taken in combination with illegal drugs or ethanol. SN - 1471-227X UR - https://www.unboundmedicine.com/medline/citation/31615421/Acute_poisoning_related_to_the_recreational_use_of_prescription_drugs:_an_observational_study_from_Oslo,_Norway L2 - https://bmcemergmed.biomedcentral.com/articles/10.1186/s12873-019-0271-0 DB - PRIME DP - Unbound Medicine ER -