Tags

Type your tag names separated by a space and hit enter

Prenatal maternal and childhood bisphenol a exposure and brain structure and behavior of young children.
Environ Health. 2019 10 15; 18(1):85.EH

Abstract

BACKGROUND

Bisphenol A (BPA) is commonly used in the manufacture of plastics and epoxy resins. In North America, over 90% of the population has detectable levels of urinary BPA. Human epidemiological studies have reported adverse behavioral outcomes with BPA exposure in children, however, corresponding effects on children's brain structure have not yet been investigated. The current study examined the association between prenatal maternal and childhood BPA exposure and white matter microstructure in children aged 2 to 5 years, and investigated whether brain structure mediated the association between BPA exposure and child behavior.

METHODS

Participants were 98 mother-child pairs who were recruited between January 2009 and December 2012. Total BPA concentrations in spot urine samples obtained from mothers in the second trimester of pregnancy and from children at 3-4 years of age were analyzed. Children participated in a diffusion magnetic resonance imaging (MRI) scan at age 2-5 years (3.7 ± 0.8 years). Associations between prenatal maternal and childhood BPA and children's fractional anisotropy and mean diffusivity of 10 isolated white matter tracts were investigated, controlling for urinary creatinine, child sex, and age at the time of MRI. Post-hoc analyses examined if alterations in white matter mediated the relationship of BPA and children's scores on the Child Behavior Checklist (CBCL).

RESULTS

Prenatal maternal urinary BPA was significantly associated with child mean diffusivity in the splenium and right inferior longitudinal fasciculus. Splenium diffusivity mediated the relationship between maternal prenatal BPA levels and children's internalizing behavior (indirect effect: β = 0.213, CI [0.0167, 0.564]). No significant associations were found between childhood BPA and white matter microstructure.

CONCLUSIONS

This study provides preliminary evidence for the neural correlates of BPA exposure in humans. Our findings suggest that prenatal maternal exposure to BPA may lead to alterations in white matter microstructure in preschool aged children, and that such alterations mediate the relationship between early life exposure to BPA and internalizing problems.

Authors+Show Affiliations

Department of Neuroscience, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Owerko Centre, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.Owerko Centre, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada. Science for Life Laboratory, Department of Environmental Science and Analytical Chemistry, Stockholm University, Stockholm, Sweden.Owerko Centre, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.Owerko Centre, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.Owerko Centre, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. dmdewey@ucalgary.ca. Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. dmdewey@ucalgary.ca. Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. dmdewey@ucalgary.ca. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. dmdewey@ucalgary.ca. University of Calgary, #397 Owerko Center, Child Development Centre 2500 University Dr. NW, Calgary, Alberta, T2N 1N4, Canada. dmdewey@ucalgary.ca.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31615514

Citation

Grohs, Melody N., et al. "Prenatal Maternal and Childhood Bisphenol a Exposure and Brain Structure and Behavior of Young Children." Environmental Health : a Global Access Science Source, vol. 18, no. 1, 2019, p. 85.
Grohs MN, Reynolds JE, Liu J, et al. Prenatal maternal and childhood bisphenol a exposure and brain structure and behavior of young children. Environ Health. 2019;18(1):85.
Grohs, M. N., Reynolds, J. E., Liu, J., Martin, J. W., Pollock, T., Lebel, C., & Dewey, D. (2019). Prenatal maternal and childhood bisphenol a exposure and brain structure and behavior of young children. Environmental Health : a Global Access Science Source, 18(1), 85. https://doi.org/10.1186/s12940-019-0528-9
Grohs MN, et al. Prenatal Maternal and Childhood Bisphenol a Exposure and Brain Structure and Behavior of Young Children. Environ Health. 2019 10 15;18(1):85. PubMed PMID: 31615514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal maternal and childhood bisphenol a exposure and brain structure and behavior of young children. AU - Grohs,Melody N, AU - Reynolds,Jess E, AU - Liu,Jiaying, AU - Martin,Jonathan W, AU - Pollock,Tyler, AU - Lebel,Catherine, AU - Dewey,Deborah, AU - ,, Y1 - 2019/10/15/ PY - 2019/03/26/received PY - 2019/09/25/accepted PY - 2019/10/17/entrez PY - 2019/10/17/pubmed PY - 2020/3/14/medline KW - Behavior KW - Bisphenol a KW - Brain development KW - Child Behavior Checklist KW - Magnetic resonance imaging KW - White matter SP - 85 EP - 85 JF - Environmental health : a global access science source JO - Environ Health VL - 18 IS - 1 N2 - BACKGROUND: Bisphenol A (BPA) is commonly used in the manufacture of plastics and epoxy resins. In North America, over 90% of the population has detectable levels of urinary BPA. Human epidemiological studies have reported adverse behavioral outcomes with BPA exposure in children, however, corresponding effects on children's brain structure have not yet been investigated. The current study examined the association between prenatal maternal and childhood BPA exposure and white matter microstructure in children aged 2 to 5 years, and investigated whether brain structure mediated the association between BPA exposure and child behavior. METHODS: Participants were 98 mother-child pairs who were recruited between January 2009 and December 2012. Total BPA concentrations in spot urine samples obtained from mothers in the second trimester of pregnancy and from children at 3-4 years of age were analyzed. Children participated in a diffusion magnetic resonance imaging (MRI) scan at age 2-5 years (3.7 ± 0.8 years). Associations between prenatal maternal and childhood BPA and children's fractional anisotropy and mean diffusivity of 10 isolated white matter tracts were investigated, controlling for urinary creatinine, child sex, and age at the time of MRI. Post-hoc analyses examined if alterations in white matter mediated the relationship of BPA and children's scores on the Child Behavior Checklist (CBCL). RESULTS: Prenatal maternal urinary BPA was significantly associated with child mean diffusivity in the splenium and right inferior longitudinal fasciculus. Splenium diffusivity mediated the relationship between maternal prenatal BPA levels and children's internalizing behavior (indirect effect: β = 0.213, CI [0.0167, 0.564]). No significant associations were found between childhood BPA and white matter microstructure. CONCLUSIONS: This study provides preliminary evidence for the neural correlates of BPA exposure in humans. Our findings suggest that prenatal maternal exposure to BPA may lead to alterations in white matter microstructure in preschool aged children, and that such alterations mediate the relationship between early life exposure to BPA and internalizing problems. SN - 1476-069X UR - https://www.unboundmedicine.com/medline/citation/31615514/Prenatal_maternal_and_childhood_bisphenol_a_exposure_and_brain_structure_and_behavior_of_young_children_ L2 - https://ehjournal.biomedcentral.com/articles/10.1186/s12940-019-0528-9 DB - PRIME DP - Unbound Medicine ER -