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Evaluation of concurrent analysis of cerebrospinal fluid samples collected from the cerebellomedullary cistern and lumbar subarachnoid space for the diagnosis of steroid-responsive meningitis arteritis in dogs.
J Am Vet Med Assoc 2019; 255(9):1035-1038JA

Abstract

OBJECTIVE

To evaluate whether concurrent analysis of CSF samples from 2 collection sites (cerebellomedullary cistern [CMC] and lumbar subarachnoid space [LSS]) versus only 1 site could improve the diagnostic sensitivity of CSF analysis for dogs with suspected steroid-responsive meningitis arteritis (SRMA).

ANIMALS

111 client-owned dogs with SRMA diagnosed at 3 veterinary referral hospitals between 2011 and 2017.

PROCEDURES

Only dogs with CSF collected from both sites (CMC and LSS) and with no previous history of corticosteroid administration were included. Medical record data and logistic regression were used to identify factors associated with having a total nucleated cell concentration (TNCC) within the reference interval in a CSF sample from 1 collection site.

RESULTS

The TNCC was within the reference interval (TNCC < 5 cells/μL) in the CSF sample from 1 collection site for 8 of 111 (7%) dogs and was only slightly high (TNCC, 5 to 9 cells/μL) in the sample from 1 or both sites for 10 (11%) other dogs. For each of these 18 dogs, results for samples from 1 site were consistent with SRMA. The proportion of CSF samples that had a TNCC within the reference interval was comparable between sites. As age increased, so did the risk of having an unremarkable TNCC in the CSF sample from 1 site, albeit only slightly (OR, 1.08; 95% confidence interval, 1.01 to 1.16).

CONCLUSIONS AND CLINICAL RELEVANCE

CSF samples from both the CMC and LSS should be analyzed when evaluating dogs with suspected SRMA to improve the chance of detecting a high TNCC.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31617801

Citation

Carletti, Beatrice E., et al. "Evaluation of Concurrent Analysis of Cerebrospinal Fluid Samples Collected From the Cerebellomedullary Cistern and Lumbar Subarachnoid Space for the Diagnosis of Steroid-responsive Meningitis Arteritis in Dogs." Journal of the American Veterinary Medical Association, vol. 255, no. 9, 2019, pp. 1035-1038.
Carletti BE, De Decker S, Rose J, et al. Evaluation of concurrent analysis of cerebrospinal fluid samples collected from the cerebellomedullary cistern and lumbar subarachnoid space for the diagnosis of steroid-responsive meningitis arteritis in dogs. J Am Vet Med Assoc. 2019;255(9):1035-1038.
Carletti, B. E., De Decker, S., Rose, J., Sanchez-Masian, D., Bersan, E., Cooper, C., ... Gonçalves, R. (2019). Evaluation of concurrent analysis of cerebrospinal fluid samples collected from the cerebellomedullary cistern and lumbar subarachnoid space for the diagnosis of steroid-responsive meningitis arteritis in dogs. Journal of the American Veterinary Medical Association, 255(9), pp. 1035-1038. doi:10.2460/javma.255.9.1035.
Carletti BE, et al. Evaluation of Concurrent Analysis of Cerebrospinal Fluid Samples Collected From the Cerebellomedullary Cistern and Lumbar Subarachnoid Space for the Diagnosis of Steroid-responsive Meningitis Arteritis in Dogs. J Am Vet Med Assoc. 2019 11 1;255(9):1035-1038. PubMed PMID: 31617801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of concurrent analysis of cerebrospinal fluid samples collected from the cerebellomedullary cistern and lumbar subarachnoid space for the diagnosis of steroid-responsive meningitis arteritis in dogs. AU - Carletti,Beatrice E, AU - De Decker,Steven, AU - Rose,Jeremy, AU - Sanchez-Masian,Daniel, AU - Bersan,Erika, AU - Cooper,Camilla, AU - Szladovits,Balazs, AU - Walmsley,Gemma, AU - Gonçalves,Rita, PY - 2019/10/17/entrez PY - 2019/10/17/pubmed PY - 2019/10/17/medline SP - 1035 EP - 1038 JF - Journal of the American Veterinary Medical Association JO - J. Am. Vet. Med. Assoc. VL - 255 IS - 9 N2 - OBJECTIVE: To evaluate whether concurrent analysis of CSF samples from 2 collection sites (cerebellomedullary cistern [CMC] and lumbar subarachnoid space [LSS]) versus only 1 site could improve the diagnostic sensitivity of CSF analysis for dogs with suspected steroid-responsive meningitis arteritis (SRMA). ANIMALS: 111 client-owned dogs with SRMA diagnosed at 3 veterinary referral hospitals between 2011 and 2017. PROCEDURES: Only dogs with CSF collected from both sites (CMC and LSS) and with no previous history of corticosteroid administration were included. Medical record data and logistic regression were used to identify factors associated with having a total nucleated cell concentration (TNCC) within the reference interval in a CSF sample from 1 collection site. RESULTS: The TNCC was within the reference interval (TNCC < 5 cells/μL) in the CSF sample from 1 collection site for 8 of 111 (7%) dogs and was only slightly high (TNCC, 5 to 9 cells/μL) in the sample from 1 or both sites for 10 (11%) other dogs. For each of these 18 dogs, results for samples from 1 site were consistent with SRMA. The proportion of CSF samples that had a TNCC within the reference interval was comparable between sites. As age increased, so did the risk of having an unremarkable TNCC in the CSF sample from 1 site, albeit only slightly (OR, 1.08; 95% confidence interval, 1.01 to 1.16). CONCLUSIONS AND CLINICAL RELEVANCE: CSF samples from both the CMC and LSS should be analyzed when evaluating dogs with suspected SRMA to improve the chance of detecting a high TNCC. SN - 1943-569X UR - https://www.unboundmedicine.com/medline/citation/31617801/Evaluation_of_concurrent_analysis_of_cerebrospinal_fluid_samples_collected_from_the_cerebellomedullary_cistern_and_lumbar_subarachnoid_space_for_the_diagnosis_of_steroid-responsive_meningitis_arteritis_in_dogs L2 - http://avmajournals.avma.org/doi/full/10.2460/javma.255.9.1035?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -