Tags

Type your tag names separated by a space and hit enter

Compression of the Choroid by Horizontal Duction.
Invest Ophthalmol Vis Sci 2019; 60(13):4285-4291IO

Abstract

Purpose

The optic nerve becomes tethered in adduction in most people, which deforms the disc. We investigated the effect of horizontal ocular duction and subject age on choroidal volume at the macular side of the optic disc.

Methods

In 25 younger (18-33 years) and 15 older (50-73 years) normal subjects, the disc and the peripapillary choroid were imaged with optical coherence tomography (OCT) in central gaze and 35° adduction and abduction. The choroid temporal to the optic disc underlying the region between the Bruch's membrane opening and fovea was segmented into regions that were multiples of the disc radius for determination of local choroidal thickness. Regional volume changes from central gaze were determined in adduction and abduction.

Results

In adduction, regional choroidal volume decreased by 42.4 ± 3.4 nanoliters (nL) (standard error of the mean) in younger (P < 0.0001) and 6.2 ± 2.6 nL in older (P < 0.02) subjects. Relative volume reduction in adduction was 7.5% ± 0.6% in younger (P < 0.001) and 1.3% ± 0.6% in older (P < 0.02) subjects. Volume reduction was greatest near the disc and significant up to three disc radii from it in younger and 1 radius in older subjects but was insignificant in abduction.

Conclusions

Horizontal duction compresses the temporal peripapillary choroid, more in adduction than in abduction and more in younger than older subjects. This reflects duction-related peripapillary tissue deformation probably related, at least in part, to optic nerve tethering in adduction.

Authors+Show Affiliations

Computational and Systems Biology Interdepartmental Program, University of California, Los Angeles, Los Angeles, California, United States.Department of Ophthalmology, University of California, Los Angeles, Los Angeles, California, United States. Bioengineering Interdepartmental Program, University of California, Los Angeles, Los Angeles, California, United States. Stein Eye Institute, University of California, Los Angeles, Los Angeles, California, United States.Department of Ophthalmology, University of California, Los Angeles, Los Angeles, California, United States. Stein Eye Institute, University of California, Los Angeles, Los Angeles, California, United States.Department of Ophthalmology, University of California, Los Angeles, Los Angeles, California, United States. Stein Eye Institute, University of California, Los Angeles, Los Angeles, California, United States.Department of Ophthalmology, University of California, Los Angeles, Los Angeles, California, United States. Bioengineering Interdepartmental Program, University of California, Los Angeles, Los Angeles, California, United States. Stein Eye Institute, University of California, Los Angeles, Los Angeles, California, United States. Department of Neurology, University of California, Los Angeles, Los Angeles, California, United States. David Geffen Medical School, University of California, Los Angeles, Los Angeles, California, United States.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31618765

Citation

Chen, Jessica Y., et al. "Compression of the Choroid By Horizontal Duction." Investigative Ophthalmology & Visual Science, vol. 60, no. 13, 2019, pp. 4285-4291.
Chen JY, Le A, De Andrade LM, et al. Compression of the Choroid by Horizontal Duction. Invest Ophthalmol Vis Sci. 2019;60(13):4285-4291.
Chen, J. Y., Le, A., De Andrade, L. M., Goseki, T., & Demer, J. L. (2019). Compression of the Choroid by Horizontal Duction. Investigative Ophthalmology & Visual Science, 60(13), pp. 4285-4291. doi:10.1167/iovs.19-27522.
Chen JY, et al. Compression of the Choroid By Horizontal Duction. Invest Ophthalmol Vis Sci. 2019 Oct 1;60(13):4285-4291. PubMed PMID: 31618765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Compression of the Choroid by Horizontal Duction. AU - Chen,Jessica Y, AU - Le,Alan, AU - De Andrade,Lindsay M, AU - Goseki,Toshiaki, AU - Demer,Joseph L, PY - 2019/10/17/entrez PY - 2019/10/17/pubmed PY - 2019/10/17/medline SP - 4285 EP - 4291 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 60 IS - 13 N2 - Purpose: The optic nerve becomes tethered in adduction in most people, which deforms the disc. We investigated the effect of horizontal ocular duction and subject age on choroidal volume at the macular side of the optic disc. Methods: In 25 younger (18-33 years) and 15 older (50-73 years) normal subjects, the disc and the peripapillary choroid were imaged with optical coherence tomography (OCT) in central gaze and 35° adduction and abduction. The choroid temporal to the optic disc underlying the region between the Bruch's membrane opening and fovea was segmented into regions that were multiples of the disc radius for determination of local choroidal thickness. Regional volume changes from central gaze were determined in adduction and abduction. Results: In adduction, regional choroidal volume decreased by 42.4 ± 3.4 nanoliters (nL) (standard error of the mean) in younger (P < 0.0001) and 6.2 ± 2.6 nL in older (P < 0.02) subjects. Relative volume reduction in adduction was 7.5% ± 0.6% in younger (P < 0.001) and 1.3% ± 0.6% in older (P < 0.02) subjects. Volume reduction was greatest near the disc and significant up to three disc radii from it in younger and 1 radius in older subjects but was insignificant in abduction. Conclusions: Horizontal duction compresses the temporal peripapillary choroid, more in adduction than in abduction and more in younger than older subjects. This reflects duction-related peripapillary tissue deformation probably related, at least in part, to optic nerve tethering in adduction. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/31618765/Compression_of_the_Choroid_by_Horizontal_Duction L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.19-27522 DB - PRIME DP - Unbound Medicine ER -