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Pathological interpretation of connective tissue disease-associated lung diseases.
Yeungnam Univ J Med 2019; 36(1):8-15YU

Abstract

Connective tissue diseases (CTDs) can affect all compartments of the lungs, including airways, alveoli, interstitium, vessels, and pleura. CTD-associated lung diseases (CTD-LDs) may present as diffuse lung disease or as focal lesions, and there is significant heterogeneity between the individual CTDs in their clinical and pathological manifestations. CTD-LDs may presage the clinical diagnosis a primary CTD, or it may develop in the context of an established CTD diagnosis. CTD-LDs reveal acute, chronic or mixed pattern of lung and pleural manifestations. Histopathological findings of diverse morphological changes can be present in CTD-LDs airway lesions (chronic bronchitis/bronchiolitis, follicular bronchiolitis, etc.), interstitial lung diseases (nonspecific interstitial pneumonia/fibrosis, usual interstitial pneumonia, lymphocytic interstitial pneumonia, diffuse alveolar damage, and organizing pneumonia), pleural changes (acute fibrinous or chronic fibrous pleuritis), and vascular changes (vasculitis, capillaritis, pulmonary hemorrhage, etc.). CTD patients can be exposed to various infectious diseases when taking immunosuppressive drugs. Histopathological patterns of CTD-LDs are generally nonspecific, and other diseases that can cause similar lesions in the lungs must be considered before the diagnosis of CTD-LDs. A multidisciplinary team involving pathologists, clinicians, and radiologists can adequately make a proper diagnosis of CTD-LDs.

Authors+Show Affiliations

Department of Pathology, Dongkang Hospital, Ulsan, Korea.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31620606

Citation

Kwon, Kun Young. "Pathological Interpretation of Connective Tissue Disease-associated Lung Diseases." Yeungnam University Journal of Medicine, vol. 36, no. 1, 2019, pp. 8-15.
Kwon KY. Pathological interpretation of connective tissue disease-associated lung diseases. Yeungnam Univ J Med. 2019;36(1):8-15.
Kwon, K. Y. (2019). Pathological interpretation of connective tissue disease-associated lung diseases. Yeungnam University Journal of Medicine, 36(1), pp. 8-15. doi:10.12701/yujm.2019.00101.
Kwon KY. Pathological Interpretation of Connective Tissue Disease-associated Lung Diseases. Yeungnam Univ J Med. 2019;36(1):8-15. PubMed PMID: 31620606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathological interpretation of connective tissue disease-associated lung diseases. A1 - Kwon,Kun Young, Y1 - 2019/01/15/ PY - 2018/11/13/received PY - 2019/01/08/revised PY - 2019/01/11/accepted PY - 2019/10/18/entrez PY - 2019/10/18/pubmed PY - 2019/10/18/medline KW - Airway diseases KW - Connective tissue diseases KW - Histopathology KW - Interstitial lung diseases KW - Pleural diseases SP - 8 EP - 15 JF - Yeungnam University journal of medicine JO - Yeungnam Univ J Med VL - 36 IS - 1 N2 - Connective tissue diseases (CTDs) can affect all compartments of the lungs, including airways, alveoli, interstitium, vessels, and pleura. CTD-associated lung diseases (CTD-LDs) may present as diffuse lung disease or as focal lesions, and there is significant heterogeneity between the individual CTDs in their clinical and pathological manifestations. CTD-LDs may presage the clinical diagnosis a primary CTD, or it may develop in the context of an established CTD diagnosis. CTD-LDs reveal acute, chronic or mixed pattern of lung and pleural manifestations. Histopathological findings of diverse morphological changes can be present in CTD-LDs airway lesions (chronic bronchitis/bronchiolitis, follicular bronchiolitis, etc.), interstitial lung diseases (nonspecific interstitial pneumonia/fibrosis, usual interstitial pneumonia, lymphocytic interstitial pneumonia, diffuse alveolar damage, and organizing pneumonia), pleural changes (acute fibrinous or chronic fibrous pleuritis), and vascular changes (vasculitis, capillaritis, pulmonary hemorrhage, etc.). CTD patients can be exposed to various infectious diseases when taking immunosuppressive drugs. Histopathological patterns of CTD-LDs are generally nonspecific, and other diseases that can cause similar lesions in the lungs must be considered before the diagnosis of CTD-LDs. A multidisciplinary team involving pathologists, clinicians, and radiologists can adequately make a proper diagnosis of CTD-LDs. SN - 2384-0293 UR - https://www.unboundmedicine.com/medline/citation/31620606/Pathological_interpretation_of_connective_tissue_disease-associated_lung_diseases L2 - http://yujm.yu.ac.kr/journal/view.php?doi=10.12701/yujm.2019.00101 DB - PRIME DP - Unbound Medicine ER -
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