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Clinical and Histological Characteristics of Mycosis Fungoides and Sézary Syndrome: A Retrospective, Single-centre Study of 43 Patients from Eastern Denmark.

Abstract

Diagnosis of mycosis fungoides and Sézary syndrome can be very challenging. Clinical and histopathological data for patients with mycosis fungoides and Sézary syndrome in Denmark are limited. A retrospective study was performed in Region Zealand, Denmark from 1990 to 2016. A total of 43 patients with mycosis fungoides or Sézary syndrome were identified during the period. At the time of diagnosis the patients' mean age was 64.3 years and 74.5% had early-stage (≤IIA) disease. The mean time from onset of skin disease to diagnosis was 4.4 years. Surprisingly, 43% progressed to a higher disease stage, and risk of disease progression was higher for stage IB than IA (p = 0.01). All cases displayed some degree of epidermotropism and the infiltrates consisted of pleomorphic lymphocytes with a T-helper (CD4+/CD8-) phenotype. This study describes, for the first time, all aspects of clinical and histopathological findings in patients with mycosis fungoides and Sézary syndrome in a well-characterized Danish cohort.

Authors+Show Affiliations

Department of Pathology, Zealand University Hospital, DK-4000 Roskilde, Denmark. piarude@dadlnet.dk.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31620804

Citation

Nielsen, Pia Rude, et al. "Clinical and Histological Characteristics of Mycosis Fungoides and Sézary Syndrome: a Retrospective, Single-centre Study of 43 Patients From Eastern Denmark." Acta Dermato-venereologica, 2019.
Nielsen PR, Eriksen JO, Wehkamp U, et al. Clinical and Histological Characteristics of Mycosis Fungoides and Sézary Syndrome: A Retrospective, Single-centre Study of 43 Patients from Eastern Denmark. Acta Derm Venereol. 2019.
Nielsen, P. R., Eriksen, J. O., Wehkamp, U., Lindahl, L. M., Gniadecki, R., Fogh, H., ... Gjerdrum, L. M. R. (2019). Clinical and Histological Characteristics of Mycosis Fungoides and Sézary Syndrome: A Retrospective, Single-centre Study of 43 Patients from Eastern Denmark. Acta Dermato-venereologica, doi:10.2340/00015555-3351.
Nielsen PR, et al. Clinical and Histological Characteristics of Mycosis Fungoides and Sézary Syndrome: a Retrospective, Single-centre Study of 43 Patients From Eastern Denmark. Acta Derm Venereol. 2019 Oct 17; PubMed PMID: 31620804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and Histological Characteristics of Mycosis Fungoides and Sézary Syndrome: A Retrospective, Single-centre Study of 43 Patients from Eastern Denmark. AU - Nielsen,Pia Rude, AU - Eriksen,Jens Ole, AU - Wehkamp,Ulrike, AU - Lindahl,Lise Maria, AU - Gniadecki,Robert, AU - Fogh,Hanne, AU - Fabricius,Susanne, AU - Bzorek,Michael, AU - Ødum,Niels, AU - Gjerdrum,Lise Mette Rahbek, Y1 - 2019/10/17/ PY - 2019/10/18/entrez KW - Sézary syndrome KW - cutaneous T-cell lymphoma KW - non-Hodgkin lymphoma KW - mycosis fungoides JF - Acta dermato-venereologica JO - Acta Derm. Venereol. N2 - Diagnosis of mycosis fungoides and Sézary syndrome can be very challenging. Clinical and histopathological data for patients with mycosis fungoides and Sézary syndrome in Denmark are limited. A retrospective study was performed in Region Zealand, Denmark from 1990 to 2016. A total of 43 patients with mycosis fungoides or Sézary syndrome were identified during the period. At the time of diagnosis the patients' mean age was 64.3 years and 74.5% had early-stage (≤IIA) disease. The mean time from onset of skin disease to diagnosis was 4.4 years. Surprisingly, 43% progressed to a higher disease stage, and risk of disease progression was higher for stage IB than IA (p = 0.01). All cases displayed some degree of epidermotropism and the infiltrates consisted of pleomorphic lymphocytes with a T-helper (CD4+/CD8-) phenotype. This study describes, for the first time, all aspects of clinical and histopathological findings in patients with mycosis fungoides and Sézary syndrome in a well-characterized Danish cohort. SN - 1651-2057 UR - https://www.unboundmedicine.com/medline/citation/31620804/Clinical_and_Histological_Characteristics_of_Mycosis_Fungoides_and_Sézary_Syndrome:_A_Retrospective,_Single-centre_Study_of_43_Patients_from_Eastern_Denmark L2 - https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-3351 DB - PRIME DP - Unbound Medicine ER -