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Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis.
Naunyn Schmiedebergs Arch Pharmacol. 2020 03; 393(3):325-337.NS

Abstract

Cyclophosphamide (CYP) is a chemotherapeutic agent used in the treatment of autoimmune disorders and malignant diseases. However, its usage is restricted due to its severe side effects, especially hepatotoxicity and nephrotoxicity. This study aimed to investigate the protective role of chrysin (CH) against CYP-induced hepatotoxicity and nephrotoxicity in rats. In the present study, 35 male Wistar rats were randomly divided into 5 groups with each group consisting of 7 rats. The rats were pretreated with CH orally in doses of 25- and 50-mg/kg body weight for 7 consecutive days, and CYP (200-mg/kg body weight, i.p.) was administrated on the 7th day 1 h after the last dose of CH. It was found that CH could ameliorate CYP-induced elevations of ALT, ALP, AST, urea, creatinine, MDA, and hepatorenal deterioration, and enhance antioxidant enzymes' activities such as SOD, CAT, and GPx, and GSH's level. Furthermore, CH reversed the changes in levels of inflammatory, apoptotic, and autophagic parameters such as NF-κB, TNF-α, IL-1β, IL-6, iNOS, COX-2, Bax, Bcl-2, and LC3B in liver and kidney tissues. To conclude, the findings of this study demonstrated that CH has a protective effect against CYP-induced hepatorenal toxicity.

Authors+Show Affiliations

Department of Solhan School of Health Services, Bingol University, Bingol, Turkey.Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.Department of Biochemistry, Faculty of Veterinary Medicine, Bingol University, 12000, Bingol, Turkey. ccaglayan@bingol.edu.tr.Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31620822

Citation

Temel, Yusuf, et al. "Protective Effect of Chrysin On Cyclophosphamide-induced Hepatotoxicity and Nephrotoxicity Via the Inhibition of Oxidative Stress, Inflammation, and Apoptosis." Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 393, no. 3, 2020, pp. 325-337.
Temel Y, Kucukler S, Yıldırım S, et al. Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis. Naunyn Schmiedebergs Arch Pharmacol. 2020;393(3):325-337.
Temel, Y., Kucukler, S., Yıldırım, S., Caglayan, C., & Kandemir, F. M. (2020). Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis. Naunyn-Schmiedeberg's Archives of Pharmacology, 393(3), 325-337. https://doi.org/10.1007/s00210-019-01741-z
Temel Y, et al. Protective Effect of Chrysin On Cyclophosphamide-induced Hepatotoxicity and Nephrotoxicity Via the Inhibition of Oxidative Stress, Inflammation, and Apoptosis. Naunyn Schmiedebergs Arch Pharmacol. 2020;393(3):325-337. PubMed PMID: 31620822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis. AU - Temel,Yusuf, AU - Kucukler,Sefa, AU - Yıldırım,Serkan, AU - Caglayan,Cuneyt, AU - Kandemir,Fatih Mehmet, Y1 - 2019/10/16/ PY - 2019/07/30/received PY - 2019/09/20/accepted PY - 2019/10/18/pubmed PY - 2019/10/18/medline PY - 2019/10/18/entrez KW - Apoptosis KW - Chrysin KW - Cyclophosphamide KW - Hepatotoxicity KW - Inflammation KW - Nephrotoxicity SP - 325 EP - 337 JF - Naunyn-Schmiedeberg's archives of pharmacology JO - Naunyn Schmiedebergs Arch Pharmacol VL - 393 IS - 3 N2 - Cyclophosphamide (CYP) is a chemotherapeutic agent used in the treatment of autoimmune disorders and malignant diseases. However, its usage is restricted due to its severe side effects, especially hepatotoxicity and nephrotoxicity. This study aimed to investigate the protective role of chrysin (CH) against CYP-induced hepatotoxicity and nephrotoxicity in rats. In the present study, 35 male Wistar rats were randomly divided into 5 groups with each group consisting of 7 rats. The rats were pretreated with CH orally in doses of 25- and 50-mg/kg body weight for 7 consecutive days, and CYP (200-mg/kg body weight, i.p.) was administrated on the 7th day 1 h after the last dose of CH. It was found that CH could ameliorate CYP-induced elevations of ALT, ALP, AST, urea, creatinine, MDA, and hepatorenal deterioration, and enhance antioxidant enzymes' activities such as SOD, CAT, and GPx, and GSH's level. Furthermore, CH reversed the changes in levels of inflammatory, apoptotic, and autophagic parameters such as NF-κB, TNF-α, IL-1β, IL-6, iNOS, COX-2, Bax, Bcl-2, and LC3B in liver and kidney tissues. To conclude, the findings of this study demonstrated that CH has a protective effect against CYP-induced hepatorenal toxicity. SN - 1432-1912 UR - https://www.unboundmedicine.com/medline/citation/31620822/Protective_effect_of_chrysin_on_cyclophosphamide_induced_hepatotoxicity_and_nephrotoxicity_via_the_inhibition_of_oxidative_stress_inflammation_and_apoptosis_ L2 - https://dx.doi.org/10.1007/s00210-019-01741-z DB - PRIME DP - Unbound Medicine ER -
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