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NMDA receptors and the ontogeny of post-shock and retention freezing during contextual fear conditioning.
Dev Psychobiol. 2020 04; 62(3):380-385.DP

Abstract

The ontogeny and NMDA-receptor (NMDAR) mechanisms of context conditioning were examined during standard contextual fear conditioning (sCFC) - involving context and context-shock learning in the same trial - as a comparison with our previous reports on the Context Preexposure Facilitation Effect (CPFE), which separates these two types of learning by 24 hr. In Experiment 1, systemic administration of the NMDAR antagonist, MK-801, prior to conditioning disrupted retention but not post-shock freezing during sCFC in PD31 rats. Experiment 2 replicated and extended this effect to PD17 versus PD31 rats. Consistent with Experiment 1, pre-training MK-801 spared post-shock freezing but impaired retention freezing in PD31 rats. In contrast, pre-training MK-801 disrupted post-shock freezing in PD17 rats, which showed no retention freezing regardless of drug. These results reveal developmental differences in the role of NMDAR activity in the acquisition versus retention of a context-shock association during sCFC in pre-weanling and adolescent rats.

Authors+Show Affiliations

Department of Psychological & Brain Sciences, University of Delaware, Newark, DE, USA.Department of Psychological & Brain Sciences, University of Delaware, Newark, DE, USA.Department of Psychological & Brain Sciences, University of Delaware, Newark, DE, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31621064

Citation

Miller, Lauren A., et al. "NMDA Receptors and the Ontogeny of Post-shock and Retention Freezing During Contextual Fear Conditioning." Developmental Psychobiology, vol. 62, no. 3, 2020, pp. 380-385.
Miller LA, Heroux NA, Stanton ME. NMDA receptors and the ontogeny of post-shock and retention freezing during contextual fear conditioning. Dev Psychobiol. 2020;62(3):380-385.
Miller, L. A., Heroux, N. A., & Stanton, M. E. (2020). NMDA receptors and the ontogeny of post-shock and retention freezing during contextual fear conditioning. Developmental Psychobiology, 62(3), 380-385. https://doi.org/10.1002/dev.21928
Miller LA, Heroux NA, Stanton ME. NMDA Receptors and the Ontogeny of Post-shock and Retention Freezing During Contextual Fear Conditioning. Dev Psychobiol. 2020;62(3):380-385. PubMed PMID: 31621064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - NMDA receptors and the ontogeny of post-shock and retention freezing during contextual fear conditioning. AU - Miller,Lauren A, AU - Heroux,Nicholas A, AU - Stanton,Mark E, Y1 - 2019/10/17/ PY - 2018/05/31/received PY - 2019/08/24/revised PY - 2019/09/15/accepted PY - 2019/10/18/pubmed PY - 2020/12/1/medline PY - 2019/10/18/entrez KW - NMDA receptor KW - amygdala KW - contextual fear conditioning KW - hippocampus KW - ontogeny SP - 380 EP - 385 JF - Developmental psychobiology JO - Dev Psychobiol VL - 62 IS - 3 N2 - The ontogeny and NMDA-receptor (NMDAR) mechanisms of context conditioning were examined during standard contextual fear conditioning (sCFC) - involving context and context-shock learning in the same trial - as a comparison with our previous reports on the Context Preexposure Facilitation Effect (CPFE), which separates these two types of learning by 24 hr. In Experiment 1, systemic administration of the NMDAR antagonist, MK-801, prior to conditioning disrupted retention but not post-shock freezing during sCFC in PD31 rats. Experiment 2 replicated and extended this effect to PD17 versus PD31 rats. Consistent with Experiment 1, pre-training MK-801 spared post-shock freezing but impaired retention freezing in PD31 rats. In contrast, pre-training MK-801 disrupted post-shock freezing in PD17 rats, which showed no retention freezing regardless of drug. These results reveal developmental differences in the role of NMDAR activity in the acquisition versus retention of a context-shock association during sCFC in pre-weanling and adolescent rats. SN - 1098-2302 UR - https://www.unboundmedicine.com/medline/citation/31621064/NMDA_receptors_and_the_ontogeny_of_post_shock_and_retention_freezing_during_contextual_fear_conditioning_ DB - PRIME DP - Unbound Medicine ER -