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Curcumin Activates the Nrf2 Pathway and Induces Cellular Protection Against Oxidative Injury.
Curr Mol Med. 2020; 20(2):116-133.CM

Abstract

Curcumin is a naturally occurring polyphenol that is isolated from the rhizome of Curcuma longa (turmeric). This medicinal compound has different biological activities, including antioxidant, antibacterial, antineoplastic, and anti-inflammatory. It also has therapeutic effects on neurodegenerative disorders, renal disorders, and diabetes mellitus. Curcumin is safe and well-tolerated at high concentrations without inducing toxicity. It seems that curcumin is capable of targeting the Nrf2 signaling pathway in protecting the cells against oxidative damage. Besides, this strategy is advantageous in cancer therapy. Accumulating data demonstrates that curcumin applies four distinct ways to stimulate the Nrf2 signaling pathway, including inhibition of Keap1, affecting the upstream mediators of Nrf2, influencing the expression of Nrf2 and target genes, and finally, improving the nuclear translocation of Nrf2. In the present review, the effects of curcumin on the Nrf2 signaling pathway to exert its therapeutic and biological activities has been discussed.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ashrafizadeh M
Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Ahmadi Z
Department of Basic Science, Veterinary Medicine Faculty, Shushtar University, Khuzestan, Iran.
Mohammadinejad R
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Farkhondeh T
Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Samarghandian S
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.

MeSH

AnimalsAnti-Inflammatory AgentsAntineoplastic Agents, PhytogenicAntioxidantsApoptosisBiological AvailabilityCardiotonic AgentsCpG IslandsCurcuminDNA MethylationHumansHypoglycemic AgentsKelch-Like ECH-Associated Protein 1KidneyLiverLungMiceMolecular StructureMuscle, SkeletalNF-E2-Related Factor 2Neuroprotective AgentsOxidative StressPhytotherapyRadiation-Protective AgentsRetinal Pigment EpitheliumSignal Transduction

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31622191

Citation

Ashrafizadeh, Milad, et al. "Curcumin Activates the Nrf2 Pathway and Induces Cellular Protection Against Oxidative Injury." Current Molecular Medicine, vol. 20, no. 2, 2020, pp. 116-133.
Ashrafizadeh M, Ahmadi Z, Mohammadinejad R, et al. Curcumin Activates the Nrf2 Pathway and Induces Cellular Protection Against Oxidative Injury. Curr Mol Med. 2020;20(2):116-133.
Ashrafizadeh, M., Ahmadi, Z., Mohammadinejad, R., Farkhondeh, T., & Samarghandian, S. (2020). Curcumin Activates the Nrf2 Pathway and Induces Cellular Protection Against Oxidative Injury. Current Molecular Medicine, 20(2), 116-133. https://doi.org/10.2174/1566524019666191016150757
Ashrafizadeh M, et al. Curcumin Activates the Nrf2 Pathway and Induces Cellular Protection Against Oxidative Injury. Curr Mol Med. 2020;20(2):116-133. PubMed PMID: 31622191.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Curcumin Activates the Nrf2 Pathway and Induces Cellular Protection Against Oxidative Injury. AU - Ashrafizadeh,Milad, AU - Ahmadi,Zahra, AU - Mohammadinejad,Reza, AU - Farkhondeh,Tahereh, AU - Samarghandian,Saeed, PY - 2019/07/30/received PY - 2019/09/11/revised PY - 2019/09/18/accepted PY - 2019/10/18/pubmed PY - 2021/6/11/medline PY - 2019/10/18/entrez KW - Curcumin KW - cancer KW - nuclear factor erythroid 2-related factor 2 KW - oxidative stress KW - therapeutic effects. SP - 116 EP - 133 JF - Current molecular medicine JO - Curr Mol Med VL - 20 IS - 2 N2 - Curcumin is a naturally occurring polyphenol that is isolated from the rhizome of Curcuma longa (turmeric). This medicinal compound has different biological activities, including antioxidant, antibacterial, antineoplastic, and anti-inflammatory. It also has therapeutic effects on neurodegenerative disorders, renal disorders, and diabetes mellitus. Curcumin is safe and well-tolerated at high concentrations without inducing toxicity. It seems that curcumin is capable of targeting the Nrf2 signaling pathway in protecting the cells against oxidative damage. Besides, this strategy is advantageous in cancer therapy. Accumulating data demonstrates that curcumin applies four distinct ways to stimulate the Nrf2 signaling pathway, including inhibition of Keap1, affecting the upstream mediators of Nrf2, influencing the expression of Nrf2 and target genes, and finally, improving the nuclear translocation of Nrf2. In the present review, the effects of curcumin on the Nrf2 signaling pathway to exert its therapeutic and biological activities has been discussed. SN - 1875-5666 UR - https://www.unboundmedicine.com/medline/citation/31622191/Curcumin_Activates_the_Nrf2_Pathway_and_Induces_Cellular_Protection_Against_Oxidative_Injury_ DB - PRIME DP - Unbound Medicine ER -