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Decreased regional homogeneity and increased functional connectivity of default network correlated with neurocognitive deficits in subjects with genetic high-risk for schizophrenia: A resting-state fMRI study.
Psychiatry Res 2019; 281:112603PR

Abstract

The complex symptoms of schizophrenia (SCZ) have been associated with dysfunction of the default mode network (DMN). Subjects at genetic high risk (GHR) for SCZ exhibit similar but milder brain abnormalities. This study aimed to investigate functional alterations of DMN from the local to the whole and their relationships with cognitive deficits in GHR subjects. 42 GHR subjects and 38 matched healthy controls (HC) were studied by resting-state functional magnetic resonance imaging (rs-fMRI). Regional homogeneity (ReHo) analysis was performed to measure the local brain function of the DMN, derived by the group independent component analysis, and areas with aberrant ReHo were used as seeds in functional connectivity (FC). Compared with the HC group, the GHR group exhibited significantly decreased ReHo and increased FC in the fronto-limbic-striatal system within the DMN. Furthermore, a significant negative correlation was found between decreased ReHo in the right superior frontal gyrus and the delayed recall in GHR subjects. Our findings revealed decreased local function and hyper-connectivity in the fronto-limbic-striatal system of the DMN in GHR subjects, which is associated with cognitive deficits. This may improve our understanding of the neurophysiological endophenotypes of SCZ and the neural substrate underlying the cognitive deficits of the disease.

Authors+Show Affiliations

Department of Psychiatry, Second Xiangya Hospital, Central South University, Changsha, China.Department of Psychiatry, Second Xiangya Hospital, Central South University, Changsha, China; Department of Clinical Medicine, Third Xiangya Hospital, Central South University, Changsha, China.Department of Radiology, Hunan Children's Hospital, Changsha, China.Department of Psychiatry, Second Xiangya Hospital, Central South University, Changsha, China.Department of Psychiatry, Second Xiangya Hospital, Central South University, Changsha, China.Department of Psychiatry, Second Xiangya Hospital, Central South University, Changsha, China.Department of Psychiatry, Second Xiangya Hospital, Central South University, Changsha, China.Department of Radiology, Hunan Children's Hospital, Changsha, China.Department of Psychiatry, Second Xiangya Hospital, Central South University, Changsha, China. Electronic address: yinghe@csu.edu.cn.Department of Psychiatry, Second Xiangya Hospital, Central South University, Changsha, China; Mental Health Institute of Central South University, Changsha, Hunan, China; China National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan, China; China National Technology Institute on Mental Disorders, Changsha, Hunan, China; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China. Electronic address: chenxiaogang@csu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31622873

Citation

Ma, Xiaoqian, et al. "Decreased Regional Homogeneity and Increased Functional Connectivity of Default Network Correlated With Neurocognitive Deficits in Subjects With Genetic High-risk for Schizophrenia: a Resting-state fMRI Study." Psychiatry Research, vol. 281, 2019, p. 112603.
Ma X, Zheng W, Li C, et al. Decreased regional homogeneity and increased functional connectivity of default network correlated with neurocognitive deficits in subjects with genetic high-risk for schizophrenia: A resting-state fMRI study. Psychiatry Res. 2019;281:112603.
Ma, X., Zheng, W., Li, C., Li, Z., Tang, J., Yuan, L., ... Chen, X. (2019). Decreased regional homogeneity and increased functional connectivity of default network correlated with neurocognitive deficits in subjects with genetic high-risk for schizophrenia: A resting-state fMRI study. Psychiatry Research, 281, p. 112603. doi:10.1016/j.psychres.2019.112603.
Ma X, et al. Decreased Regional Homogeneity and Increased Functional Connectivity of Default Network Correlated With Neurocognitive Deficits in Subjects With Genetic High-risk for Schizophrenia: a Resting-state fMRI Study. Psychiatry Res. 2019;281:112603. PubMed PMID: 31622873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased regional homogeneity and increased functional connectivity of default network correlated with neurocognitive deficits in subjects with genetic high-risk for schizophrenia: A resting-state fMRI study. AU - Ma,Xiaoqian, AU - Zheng,Wenxiao, AU - Li,Chunwang, AU - Li,Zongchang, AU - Tang,Jinsong, AU - Yuan,Liu, AU - Ouyang,Lijun, AU - Jin,Ke, AU - He,Ying, AU - Chen,Xiaogang, Y1 - 2019/10/07/ PY - 2019/07/04/received PY - 2019/10/04/revised PY - 2019/10/04/accepted PY - 2019/10/18/pubmed PY - 2019/10/18/medline PY - 2019/10/18/entrez KW - Default mode network KW - Functional connectivity KW - Genetic high risk KW - Regional homogeneity KW - Resting-state KW - Schizophrenia SP - 112603 EP - 112603 JF - Psychiatry research JO - Psychiatry Res VL - 281 N2 - The complex symptoms of schizophrenia (SCZ) have been associated with dysfunction of the default mode network (DMN). Subjects at genetic high risk (GHR) for SCZ exhibit similar but milder brain abnormalities. This study aimed to investigate functional alterations of DMN from the local to the whole and their relationships with cognitive deficits in GHR subjects. 42 GHR subjects and 38 matched healthy controls (HC) were studied by resting-state functional magnetic resonance imaging (rs-fMRI). Regional homogeneity (ReHo) analysis was performed to measure the local brain function of the DMN, derived by the group independent component analysis, and areas with aberrant ReHo were used as seeds in functional connectivity (FC). Compared with the HC group, the GHR group exhibited significantly decreased ReHo and increased FC in the fronto-limbic-striatal system within the DMN. Furthermore, a significant negative correlation was found between decreased ReHo in the right superior frontal gyrus and the delayed recall in GHR subjects. Our findings revealed decreased local function and hyper-connectivity in the fronto-limbic-striatal system of the DMN in GHR subjects, which is associated with cognitive deficits. This may improve our understanding of the neurophysiological endophenotypes of SCZ and the neural substrate underlying the cognitive deficits of the disease. SN - 1872-7123 UR - https://www.unboundmedicine.com/medline/citation/31622873/Decreased_regional_homogeneity_and_increased_functional_connectivity_of_default_network_correlated_with_neurocognitive_deficits_in_subjects_with_genetic_high_risk_for_schizophrenia:_A_resting_state_fMRI_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(19)31441-6 DB - PRIME DP - Unbound Medicine ER -