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Primary hypoparathyroidism accompanied by rhabdomyolysis induced by infection: A case report.
World J Clin Cases 2019; 7(19):3111-3119WJ

Abstract

BACKGROUND

Primary hypoparathyroidism (HPT) is rarely seen in the clinic, and it can be combined with rhabdomyolysis. There are few reports about this phenomenon. Therefore, it is significant to explore the etiology that is conducive to early diagnosis, timely treatment, and preventing the recurrence.

CASE SUMMARY

A 63-year-old man was admitted to our hospital with a severe upper respiratory tract infection and progressing decreased myodynamia of the lower limbs. Blood tests showed creatine kinase > 32000 U/L, creatinine 207.8 µmol/L, calcium 1.28 mmol/L, myoglobin 558.7 ng/mL, and parathyroid hormone 0 pg/mL. He was diagnosed with primary HPT with rhabdomyolysis, and severe upper respiratory tract infection was considered to be the initial trigger. He responded well to supplementation of intravenous calcium gluconate and oral calcium as well as bedside hemodialysis, fluid hydration, infection control, protecting the liver, etc. Creatine kinase, myoglobin, and serum calcium returned to normal, and muscle strength improved significantly. Symptoms improved after symptomatic treatment.

CONCLUSION

Severe infection should be prevented, which is the key cause of rhabdomyolysis in patients with HPT.

Authors+Show Affiliations

Department of Endocrinology, the Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Hospital of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.No affiliation info availableDepartment of General Surgery, Zhangjiagang Traditional Chinese Medicine Hospital affiliated with Nanjing University of Chinese Medicine, Zhangjiagang 215600, Jiangsu Province, China.Department of Endocrinology, the Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Hospital of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Endocrinology, the Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Hospital of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Gynecology and Obstetrics, Changshu Traditional Chinese Medicine Hospital affiliated with Nanjing University of Chinese Medicine, Changshu 215500, Jiangsu Province, China.Department of Endocrinology, the Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Hospital of Chinese Medicine, Nanjing 210029, Jiangsu Province, China. wbshang@njucm.edu.cn.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31624762

Citation

Ding, Li-Na, et al. "Primary Hypoparathyroidism Accompanied By Rhabdomyolysis Induced By Infection: a Case Report." World Journal of Clinical Cases, vol. 7, no. 19, 2019, pp. 3111-3119.
Ding LN, Wang Y, Tian J, et al. Primary hypoparathyroidism accompanied by rhabdomyolysis induced by infection: A case report. World J Clin Cases. 2019;7(19):3111-3119.
Ding, L. N., Wang, Y., Tian, J., Ye, L. F., Chen, S., Wu, S. M., & Shang, W. B. (2019). Primary hypoparathyroidism accompanied by rhabdomyolysis induced by infection: A case report. World Journal of Clinical Cases, 7(19), pp. 3111-3119. doi:10.12998/wjcc.v7.i19.3111.
Ding LN, et al. Primary Hypoparathyroidism Accompanied By Rhabdomyolysis Induced By Infection: a Case Report. World J Clin Cases. 2019 Oct 6;7(19):3111-3119. PubMed PMID: 31624762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary hypoparathyroidism accompanied by rhabdomyolysis induced by infection: A case report. AU - Ding,Li-Na, AU - Wang,Yi, AU - Tian,Jun, AU - Ye,Li-Fang, AU - Chen,Shi, AU - Wu,Shi-Min, AU - Shang,Wen-Bin, PY - 2019/07/11/received PY - 2019/08/12/revised PY - 2019/09/11/accepted PY - 2019/10/19/entrez PY - 2019/10/19/pubmed PY - 2019/10/19/medline KW - Case report KW - Decreased myodynamia KW - Hypocalcemia KW - Primary hypoparathyroidism KW - Respiratory tract infection KW - Rhabdomyolysis SP - 3111 EP - 3119 JF - World journal of clinical cases JO - World J Clin Cases VL - 7 IS - 19 N2 - BACKGROUND: Primary hypoparathyroidism (HPT) is rarely seen in the clinic, and it can be combined with rhabdomyolysis. There are few reports about this phenomenon. Therefore, it is significant to explore the etiology that is conducive to early diagnosis, timely treatment, and preventing the recurrence. CASE SUMMARY: A 63-year-old man was admitted to our hospital with a severe upper respiratory tract infection and progressing decreased myodynamia of the lower limbs. Blood tests showed creatine kinase > 32000 U/L, creatinine 207.8 µmol/L, calcium 1.28 mmol/L, myoglobin 558.7 ng/mL, and parathyroid hormone 0 pg/mL. He was diagnosed with primary HPT with rhabdomyolysis, and severe upper respiratory tract infection was considered to be the initial trigger. He responded well to supplementation of intravenous calcium gluconate and oral calcium as well as bedside hemodialysis, fluid hydration, infection control, protecting the liver, etc. Creatine kinase, myoglobin, and serum calcium returned to normal, and muscle strength improved significantly. Symptoms improved after symptomatic treatment. CONCLUSION: Severe infection should be prevented, which is the key cause of rhabdomyolysis in patients with HPT. SN - 2307-8960 UR - https://www.unboundmedicine.com/medline/citation/31624762/Primary_hypoparathyroidism_accompanied_by_rhabdomyolysis_induced_by_infection:_A_case_report L2 - http://www.wjgnet.com/2307-8960/full/v7/i19/3111.htm DB - PRIME DP - Unbound Medicine ER -