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Measles, the need for a paradigm shift.
Eur J Epidemiol 2019; 34(10):897-915EJ

Abstract

Measles vaccination schedules and targets of herd immunity have been designed according to the paradigm that the vaccine is as protective as natural infection, and the virus has remained of a single serotype over many decades. As a result, ongoing measles resurgence is mostly attributed to gaps in immunization. Using official data, we investigated the correlation between the rate of vaccine coverage reported and aggregated at the national level, and the incidence of cases. We discussed the limits of this indicator considered in isolation. We provide a literature overview of measles vaccine efficacy and failures. We questioned whether measles strains could escape the vaccine. Immunization tools and strategies for measles control deserve to be optimized in the current context.

Authors+Show Affiliations

Laveran Military Teaching Hospital, 34 Boulevard Alphonse Laveran, 13013, Marseille, France. emilie.javelle@gmail.com. IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France. emilie.javelle@gmail.com. IRD, AP-HM, SSA, VITROME, Aix Marseille University, Marseille, France. emilie.javelle@gmail.com.IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France. IRD, AP-HM, SSA, MEPHI, Aix Marseille University, Marseille, France.IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France. IRD, AP-HM, SSA, VITROME, Aix Marseille University, Marseille, France.IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France. IRD, AP-HM, SSA, MEPHI, Aix Marseille University, Marseille, France.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31624970

Citation

Javelle, Emilie, et al. "Measles, the Need for a Paradigm Shift." European Journal of Epidemiology, vol. 34, no. 10, 2019, pp. 897-915.
Javelle E, Colson P, Parola P, et al. Measles, the need for a paradigm shift. Eur J Epidemiol. 2019;34(10):897-915.
Javelle, E., Colson, P., Parola, P., & Raoult, D. (2019). Measles, the need for a paradigm shift. European Journal of Epidemiology, 34(10), pp. 897-915. doi:10.1007/s10654-019-00569-4.
Javelle E, et al. Measles, the Need for a Paradigm Shift. Eur J Epidemiol. 2019;34(10):897-915. PubMed PMID: 31624970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measles, the need for a paradigm shift. AU - Javelle,Emilie, AU - Colson,Philippe, AU - Parola,Philippe, AU - Raoult,Didier, Y1 - 2019/10/17/ PY - 2019/07/17/received PY - 2019/10/03/accepted PY - 2019/10/19/pubmed PY - 2019/10/19/medline PY - 2019/10/19/entrez KW - Coverage KW - Efficacy KW - Genotype KW - Immunization KW - Measles vaccine SP - 897 EP - 915 JF - European journal of epidemiology JO - Eur. J. Epidemiol. VL - 34 IS - 10 N2 - Measles vaccination schedules and targets of herd immunity have been designed according to the paradigm that the vaccine is as protective as natural infection, and the virus has remained of a single serotype over many decades. As a result, ongoing measles resurgence is mostly attributed to gaps in immunization. Using official data, we investigated the correlation between the rate of vaccine coverage reported and aggregated at the national level, and the incidence of cases. We discussed the limits of this indicator considered in isolation. We provide a literature overview of measles vaccine efficacy and failures. We questioned whether measles strains could escape the vaccine. Immunization tools and strategies for measles control deserve to be optimized in the current context. SN - 1573-7284 UR - https://www.unboundmedicine.com/medline/citation/31624970/Measles,_the_need_for_a_paradigm_shift L2 - https://doi.org/10.1007/s10654-019-00569-4 DB - PRIME DP - Unbound Medicine ER -