Tags

Type your tag names separated by a space and hit enter

Origin and Evolution of the Neuroendocrine Control of Reproduction in Vertebrates, with Special Focus on Genome and Gene Duplications.

Abstract

In human, as in the other mammals, the neuroendocrine control of reproduction is ensured by the brain-pituitary gonadotropic axis. Multiple internal and environmental cues are integrated via brain neuronal networks, ultimately leading to the modulation of the activity of gonadotropin-releasing hormone (GnRH) neurons. The decapeptide GnRH is released into the hypothalamic-hypophyseal portal blood system, and stimulates the production of pituitary glycoprotein hormones, the two gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). A novel actor, the neuropeptide Kiss, acting upstream of GnRH, has attracted increasing attention in recent years. Other neuropeptides, such as gonadotropin-inhibiting hormone (GnIH)/ RF-amide related peptide (RFRP), and other members of the RF-amide peptide superfamily, as well as various non-peptidic neuromediators such has dopamine, serotonin also provide a large panel of stimulatory or inhibitory regulators. This paper addresses the origin and evolution of the vertebrate gonadotropic axis. Brain-pituitary neuroendocrine axes are typical of vertebrates, the pituitary gland, mediator and amplifier of brain control on peripheral organs, being a vertebrate innovation. The paper reviews, from molecular and functional perspectives, the evolution across vertebrate radiation of some key-actors of the vertebrate neuroendocrine control of reproduction, and traces back their origin along the vertebrate lineage and in other metazoa before the emergence of vertebrates. A focus is given on how gene duplications, resulting from either local events or from whole genome duplication events (WGD), and followed by paralogous gene loss or conservation, might have shaped the evolutionary scenarios of current families of key-actors of the gonadotropic axis.

Authors+Show Affiliations

BOREA, CNRS-MNHN, France.INSERM U1133-Institut de Biologie Fonctionnelle et Adaptative, CNRS-Université Paris Diderot, France.UMR CNRS 7221 Physiologie moléculaire et adaptation, MNHN, France.Institut des Neurosciences Paris-Saclay, CNRS, France.United States.BOREA, MNHN, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31625459

Citation

Dufour, Sylvie, et al. "Origin and Evolution of the Neuroendocrine Control of Reproduction in Vertebrates, With Special Focus On Genome and Gene Duplications." Physiological Reviews, 2019.
Dufour S, Quérat B, Tostivint H, et al. Origin and Evolution of the Neuroendocrine Control of Reproduction in Vertebrates, with Special Focus on Genome and Gene Duplications. Physiol Rev. 2019.
Dufour, S., Quérat, B., Tostivint, H., Pasqualini, C., Vaudry, H., & Rousseau, K. (2019). Origin and Evolution of the Neuroendocrine Control of Reproduction in Vertebrates, with Special Focus on Genome and Gene Duplications. Physiological Reviews, doi:10.1152/physrev.00009.2019.
Dufour S, et al. Origin and Evolution of the Neuroendocrine Control of Reproduction in Vertebrates, With Special Focus On Genome and Gene Duplications. Physiol Rev. 2019 Oct 18; PubMed PMID: 31625459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Origin and Evolution of the Neuroendocrine Control of Reproduction in Vertebrates, with Special Focus on Genome and Gene Duplications. AU - Dufour,Sylvie, AU - Quérat,Bruno, AU - Tostivint,Hervé, AU - Pasqualini,Catherine, AU - Vaudry,Hubert, AU - Rousseau,Karine, Y1 - 2019/10/18/ PY - 2019/10/19/entrez KW - Evolution KW - Neuroendocrinology KW - Reproduction JF - Physiological reviews JO - Physiol. Rev. N2 - In human, as in the other mammals, the neuroendocrine control of reproduction is ensured by the brain-pituitary gonadotropic axis. Multiple internal and environmental cues are integrated via brain neuronal networks, ultimately leading to the modulation of the activity of gonadotropin-releasing hormone (GnRH) neurons. The decapeptide GnRH is released into the hypothalamic-hypophyseal portal blood system, and stimulates the production of pituitary glycoprotein hormones, the two gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). A novel actor, the neuropeptide Kiss, acting upstream of GnRH, has attracted increasing attention in recent years. Other neuropeptides, such as gonadotropin-inhibiting hormone (GnIH)/ RF-amide related peptide (RFRP), and other members of the RF-amide peptide superfamily, as well as various non-peptidic neuromediators such has dopamine, serotonin also provide a large panel of stimulatory or inhibitory regulators. This paper addresses the origin and evolution of the vertebrate gonadotropic axis. Brain-pituitary neuroendocrine axes are typical of vertebrates, the pituitary gland, mediator and amplifier of brain control on peripheral organs, being a vertebrate innovation. The paper reviews, from molecular and functional perspectives, the evolution across vertebrate radiation of some key-actors of the vertebrate neuroendocrine control of reproduction, and traces back their origin along the vertebrate lineage and in other metazoa before the emergence of vertebrates. A focus is given on how gene duplications, resulting from either local events or from whole genome duplication events (WGD), and followed by paralogous gene loss or conservation, might have shaped the evolutionary scenarios of current families of key-actors of the gonadotropic axis. SN - 1522-1210 UR - https://www.unboundmedicine.com/medline/citation/31625459/Origin_and_Evolution_of_the_Neuroendocrine_Control_of_Reproduction_in_Vertebrates,_with_Special_Focus_on_Genome_and_Gene_Duplications L2 - http://www.physiology.org/doi/full/10.1152/physrev.00009.2019?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -