Tags

Type your tag names separated by a space and hit enter

Altered fibrin clot properties and fibrinolysis in patients with atrial fibrillation: practical implications.
Europace 2019E

Abstract

Compelling evidence indicates that a hypercoagulable state occurs in patients with atrial fibrillation (AF) including those in sinus rhythm following paroxysmal and persistent AF. Activation of blood coagulation in AF reflects heightened thrombin generation with the subsequent increased formation of fibrin as evidenced by elevated soluble fibrin monomers and D-dimer. Formation of denser fibrin meshworks, relatively resistant to plasmin-mediated lysis has been demonstrated in patients with AF. The presence of stroke risk factors in AF, such as diabetes, heart failure, hypertension, previous myocardial infarction, or stroke, advanced age have been shown to be linked to the prothrombotic clot characteristics, including reduced clot permeability and lysability. Importantly, biomarkers, including cardiac troponins and N-terminal pro-brain natriuretic peptide, are associated with thrombin generation and fibrin-related markers in AF patients. Recently, increased fibrin clot density (low clot permeability measured in plasma-based assays) and impaired fibrinolysis measured off anticoagulation have been demonstrated to predict ischaemic cerebrovascular events in patients with AF receiving vitamin K antagonists and those on rivaroxaban. The current review summarizes evidence for a role of altered fibrin clot properties and hypofibrinolysis in AF and their prognostic value in terms of adverse events.

Authors+Show Affiliations

Institute of Cardiology, Jagiellonian University School of Medicine and John Paul II Hospital, 80 Prądnicka Str., 31-202 Cracow, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31625555

Citation

Undas, Anetta. "Altered Fibrin Clot Properties and Fibrinolysis in Patients With Atrial Fibrillation: Practical Implications." Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, 2019.
Undas A. Altered fibrin clot properties and fibrinolysis in patients with atrial fibrillation: practical implications. Europace. 2019.
Undas, A. (2019). Altered fibrin clot properties and fibrinolysis in patients with atrial fibrillation: practical implications. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, doi:10.1093/europace/euz271.
Undas A. Altered Fibrin Clot Properties and Fibrinolysis in Patients With Atrial Fibrillation: Practical Implications. Europace. 2019 Oct 18; PubMed PMID: 31625555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered fibrin clot properties and fibrinolysis in patients with atrial fibrillation: practical implications. A1 - Undas,Anetta, Y1 - 2019/10/18/ PY - 2019/05/20/received PY - 2019/09/12/accepted PY - 2019/10/19/entrez KW - Anticoagulation KW - Atrial fibrillation KW - Clot KW - Fibrin KW - Hypercoagulable state KW - Marker KW - Stroke JF - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology JO - Europace N2 - Compelling evidence indicates that a hypercoagulable state occurs in patients with atrial fibrillation (AF) including those in sinus rhythm following paroxysmal and persistent AF. Activation of blood coagulation in AF reflects heightened thrombin generation with the subsequent increased formation of fibrin as evidenced by elevated soluble fibrin monomers and D-dimer. Formation of denser fibrin meshworks, relatively resistant to plasmin-mediated lysis has been demonstrated in patients with AF. The presence of stroke risk factors in AF, such as diabetes, heart failure, hypertension, previous myocardial infarction, or stroke, advanced age have been shown to be linked to the prothrombotic clot characteristics, including reduced clot permeability and lysability. Importantly, biomarkers, including cardiac troponins and N-terminal pro-brain natriuretic peptide, are associated with thrombin generation and fibrin-related markers in AF patients. Recently, increased fibrin clot density (low clot permeability measured in plasma-based assays) and impaired fibrinolysis measured off anticoagulation have been demonstrated to predict ischaemic cerebrovascular events in patients with AF receiving vitamin K antagonists and those on rivaroxaban. The current review summarizes evidence for a role of altered fibrin clot properties and hypofibrinolysis in AF and their prognostic value in terms of adverse events. SN - 1532-2092 UR - https://www.unboundmedicine.com/medline/citation/31625555/Altered_fibrin_clot_properties_and_fibrinolysis_in_patients_with_atrial_fibrillation:_practical_implications L2 - https://academic.oup.com/europace/article-lookup/doi/10.1093/europace/euz271 DB - PRIME DP - Unbound Medicine ER -
Unbound Prime app for iOS iPhone iPadUnbound PubMed app for AndroidAlso Available:
Unbound MEDLINE
Unbound PubMed app for Windows