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Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis.
Turk J Gastroenterol 2019; 30(10):899-902TJ

Abstract

BACKGROUND/AIMS

The aim of this study was to compare the dynamic thiol/disulfide (SS) homeostasis and ischemia-modified albumin (IMA) concentration between healthy subjects and patients with mild acute pancreatitis (AP).

MATERIALS AND METHODS

A total of 28 patients with AP (AP group) and 35 age- and sex-matched healthy individuals (control group) were included in this study. Serum thiols/SS and IMA concentrations were measured and compared between the two groups.

RESULTS

The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower in the AP group than in the control group (224.7±80.3 μmol/L vs. 314.66±87.5 μmol/L, p<0.001 and 273.3±76.8 vs. 346.9±79 μmol/L, p<0.001, respectively). SS levels were significantly higher in the AP group than in the control group (24.2±11.1 μmol/L vs. 16.1±9.9 μmol/L, p<0.054). There were no differences in the IMA concentration and the mean IMA/albumin ratio (IMAR) between both the groups.

CONCLUSION

We found that mild AP may affect serum thiol and SS levels, and cause impaired thiol/SS homeostasis.

Authors+Show Affiliations

Department of Gastroenterology, Harran University School of Medicine, Şanlıurfa, Turkey.Department of Endocrinology and Metabolism, Harran University School of Medicine, Şanlıurfa, Turkey.Department of Internal Medicine, Harran University School of Medicine, Şanlıurfa, Turkey.Department of Internal Medicine, Harran University School of Medicine, Şanlıurfa, Turkey.Department of Biochemistry, Harran University School of Medicine, Şanlıurfa, Turkey.Department of Biochemistry, Harran University School of Medicine, Şanlıurfa, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31625932

Citation

Uyanıkoğlu, Ahmet, et al. "Impaired Thiol/disulfide Homeostasis in Patients With Mild Acute Pancreatitis." The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology, vol. 30, no. 10, 2019, pp. 899-902.
Uyanıkoğlu A, Sabuncu T, Yıldız R, et al. Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. Turk J Gastroenterol. 2019;30(10):899-902.
Uyanıkoğlu, A., Sabuncu, T., Yıldız, R., Cindioğlu, Ç., Kirmit, A., & Erel, Ö. (2019). Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology, 30(10), pp. 899-902. doi:10.5152/tjg.2019.18775.
Uyanıkoğlu A, et al. Impaired Thiol/disulfide Homeostasis in Patients With Mild Acute Pancreatitis. Turk J Gastroenterol. 2019;30(10):899-902. PubMed PMID: 31625932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. AU - Uyanıkoğlu,Ahmet, AU - Sabuncu,Tevfik, AU - Yıldız,Rukiye, AU - Cindioğlu,Çiğdem, AU - Kirmit,Adnan, AU - Erel,Özcan, PY - 2019/10/19/entrez PY - 2019/10/19/pubmed PY - 2019/10/19/medline SP - 899 EP - 902 JF - The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology JO - Turk J Gastroenterol VL - 30 IS - 10 N2 - BACKGROUND/AIMS: The aim of this study was to compare the dynamic thiol/disulfide (SS) homeostasis and ischemia-modified albumin (IMA) concentration between healthy subjects and patients with mild acute pancreatitis (AP). MATERIALS AND METHODS: A total of 28 patients with AP (AP group) and 35 age- and sex-matched healthy individuals (control group) were included in this study. Serum thiols/SS and IMA concentrations were measured and compared between the two groups. RESULTS: The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower in the AP group than in the control group (224.7±80.3 μmol/L vs. 314.66±87.5 μmol/L, p<0.001 and 273.3±76.8 vs. 346.9±79 μmol/L, p<0.001, respectively). SS levels were significantly higher in the AP group than in the control group (24.2±11.1 μmol/L vs. 16.1±9.9 μmol/L, p<0.054). There were no differences in the IMA concentration and the mean IMA/albumin ratio (IMAR) between both the groups. CONCLUSION: We found that mild AP may affect serum thiol and SS levels, and cause impaired thiol/SS homeostasis. SN - 2148-5607 UR - https://www.unboundmedicine.com/medline/citation/31625932/Impaired_thiol/disulfide_homeostasis_in_patients_with_mild_acute_pancreatitis L2 - https://doi.org/10.5152/tjg.2019.18775 DB - PRIME DP - Unbound Medicine ER -