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Effect of daily consumption of extra virgin olive oil on the lipid profile and microbiota of HIV-infected patients over 50 years of age.
Medicine (Baltimore) 2019; 98(42):e17528M

Abstract

BACKGROUND

Extra virgin olive oil (EVOO) has shown beneficial effects on the lipid profile and inflammatory parameters in general population. Our goal is to analyze these changes together with those of intestinal microbiota in human immunodeficiency virus (HIV)-infected patients over 50 years of age.

METHODS

Experimental single arm open study. HIV patients over the age of 50 with undetectable viral load were selected. EVOO was distributed among the patients so that each one consumed 50 g daily for 12 weeks. Lipid profile, C-reactive protein (CRP), and intestinal microbiota composition were analyzed at the beginning and at the end of the intervention.

RESULTS

Total cholesterol decreased significantly (5 mg/dL), and a nonsignificant decrease in low-density lipoprotein cholesterol (12 mg/dL), triglycerides (21 mg/dL), and CRP (1.25 mg/dL) was observed. There was a significant increase in alpha diversity after the intervention in men and a decrease in proinflammatory genera such as Dethiosulfovibrionaceae was observed. Differences were also observed in the microbiota of men and women and according to the type of antiretroviral treatment.

CONCLUSION

Sustained consumption of 50 g of EVOO in elderly HIV-infected patients might be associated with an improvement in lipid profile and alfa diversity of intestinal microbiota.

Authors+Show Affiliations

Servicio de Medicina Interna, Hospital Costa del Sol, Marbella.Servicio de Medicina Interna, Hospital Costa del Sol, Marbella.Instituto de Investigación Biosanitaria IBS.Servicio de Medicina Interna, Hospital Costa del Sol, Marbella.Instituto de Investigación Biosanitaria IBS.Servicio de Medicina Interna, Hospital Costa del Sol, Marbella.Instituto de Investigación Biosanitaria IBS. Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada. Institute of Nutrition and Food Technology "José Mataix", Center of Biomedical Research, University of Granada, Granada.Servicio de Medicina Interna, Hospital Costa del Sol, Marbella.Servicio de Medicina Interna, Hospital Costa del Sol, Marbella.Servicio de Medicina Interna, Hospital Costa del Sol, Marbella.Unidad de Microbiología, Hospital Costa del Sol, Marbella, Spain.Instituto de Investigación Biosanitaria IBS.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

31626113

Citation

Olalla, Julián, et al. "Effect of Daily Consumption of Extra Virgin Olive Oil On the Lipid Profile and Microbiota of HIV-infected Patients Over 50 Years of Age." Medicine, vol. 98, no. 42, 2019, pp. e17528.
Olalla J, García de Lomas JM, Chueca N, et al. Effect of daily consumption of extra virgin olive oil on the lipid profile and microbiota of HIV-infected patients over 50 years of age. Medicine (Baltimore). 2019;98(42):e17528.
Olalla, J., García de Lomas, J. M., Chueca, N., Pérez-Stachowski, X., De Salazar, A., Del Arco, A., ... García, F. (2019). Effect of daily consumption of extra virgin olive oil on the lipid profile and microbiota of HIV-infected patients over 50 years of age. Medicine, 98(42), pp. e17528. doi:10.1097/MD.0000000000017528.
Olalla J, et al. Effect of Daily Consumption of Extra Virgin Olive Oil On the Lipid Profile and Microbiota of HIV-infected Patients Over 50 Years of Age. Medicine (Baltimore). 2019;98(42):e17528. PubMed PMID: 31626113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of daily consumption of extra virgin olive oil on the lipid profile and microbiota of HIV-infected patients over 50 years of age. AU - Olalla,Julián, AU - García de Lomas,José M, AU - Chueca,Natalia, AU - Pérez-Stachowski,Xavier, AU - De Salazar,Adolfo, AU - Del Arco,Alfonso, AU - Plaza-Díaz,Julio, AU - De la Torre,Javier, AU - Prada,José Luis, AU - García-Alegría,Javier, AU - Fernández-Sánchez,Fernando, AU - García,Federico, PY - 2019/10/19/entrez PY - 2019/10/19/pubmed PY - 2019/11/7/medline SP - e17528 EP - e17528 JF - Medicine JO - Medicine (Baltimore) VL - 98 IS - 42 N2 - BACKGROUND: Extra virgin olive oil (EVOO) has shown beneficial effects on the lipid profile and inflammatory parameters in general population. Our goal is to analyze these changes together with those of intestinal microbiota in human immunodeficiency virus (HIV)-infected patients over 50 years of age. METHODS: Experimental single arm open study. HIV patients over the age of 50 with undetectable viral load were selected. EVOO was distributed among the patients so that each one consumed 50 g daily for 12 weeks. Lipid profile, C-reactive protein (CRP), and intestinal microbiota composition were analyzed at the beginning and at the end of the intervention. RESULTS: Total cholesterol decreased significantly (5 mg/dL), and a nonsignificant decrease in low-density lipoprotein cholesterol (12 mg/dL), triglycerides (21 mg/dL), and CRP (1.25 mg/dL) was observed. There was a significant increase in alpha diversity after the intervention in men and a decrease in proinflammatory genera such as Dethiosulfovibrionaceae was observed. Differences were also observed in the microbiota of men and women and according to the type of antiretroviral treatment. CONCLUSION: Sustained consumption of 50 g of EVOO in elderly HIV-infected patients might be associated with an improvement in lipid profile and alfa diversity of intestinal microbiota. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/31626113/Effect_of_daily_consumption_of_extra_virgin_olive_oil_on_the_lipid_profile_and_microbiota_of_HIV-infected_patients_over_50_years_of_age L2 - http://dx.doi.org/10.1097/MD.0000000000017528 DB - PRIME DP - Unbound Medicine ER -