Tags

Type your tag names separated by a space and hit enter

Risk factors for the development of hyperuricemia: A STROBE-compliant cross-sectional and longitudinal study.
Medicine (Baltimore) 2019; 98(42):e17597M

Abstract

Hyperuricemia has received increasing attention as a major public health problem. This study aims to investigate the risk factors for hyperuricemia and to explore the relationship between changes in biochemical variables and incident hyperuricemia.A cross-sectional and subsequently prospective study was performed among adults who took their health checkups at Zhejiang University Hospital. The participants who were free of hyperuricemia at baseline received annual follow-up examinations during a 6-year period. Cox proportional hazards regression analyses were conducted to calculate the risks for incident hyperuricemia.Of the 9238 participants enrolled, 1704 (18.4%) were diagnosed as hyperuricemia. During 21,757 person-years of follow-up, 1492 incident hyperuricemia cases were identified. The incidence of hyperuricemia was 68.58 cases per 1000 person-year of follow-up in the overall participants. The prevalence and the incidence of hyperuricemia increased greatly in female older than 50 years. High levels of BMI, SBP, FPG, TG, LDL-C, ALT, BUN, and creatinine increased the risk of hyperuricemia. Suffering fatty liver also increased the risk of hyperuricemia. Subjects with increasing DBP, TG, BUN, creatinine, or decreasing HDL-C were more likely to incident hyperuricemia.This study revealed that the change of diastolic blood pressure (DBP), serum triglycerides (TG), blood urea nitrogen (BUN), creatinine, and high-density lipoprotein cholesterol (HDL-C) level were independently associated with incident hyperuricemia.

Authors+Show Affiliations

Healthcare Center, Zhejiang University Hospital, Hangzhou, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31626136

Citation

Ni, Qun, et al. "Risk Factors for the Development of Hyperuricemia: a STROBE-compliant Cross-sectional and Longitudinal Study." Medicine, vol. 98, no. 42, 2019, pp. e17597.
Ni Q, Lu X, Chen C, et al. Risk factors for the development of hyperuricemia: A STROBE-compliant cross-sectional and longitudinal study. Medicine (Baltimore). 2019;98(42):e17597.
Ni, Q., Lu, X., Chen, C., Du, H., & Zhang, R. (2019). Risk factors for the development of hyperuricemia: A STROBE-compliant cross-sectional and longitudinal study. Medicine, 98(42), pp. e17597. doi:10.1097/MD.0000000000017597.
Ni Q, et al. Risk Factors for the Development of Hyperuricemia: a STROBE-compliant Cross-sectional and Longitudinal Study. Medicine (Baltimore). 2019;98(42):e17597. PubMed PMID: 31626136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for the development of hyperuricemia: A STROBE-compliant cross-sectional and longitudinal study. AU - Ni,Qun, AU - Lu,Xiaomin, AU - Chen,Congcong, AU - Du,Huaqing, AU - Zhang,Renbing, PY - 2019/10/19/entrez PY - 2019/10/19/pubmed PY - 2019/10/19/medline SP - e17597 EP - e17597 JF - Medicine JO - Medicine (Baltimore) VL - 98 IS - 42 N2 - Hyperuricemia has received increasing attention as a major public health problem. This study aims to investigate the risk factors for hyperuricemia and to explore the relationship between changes in biochemical variables and incident hyperuricemia.A cross-sectional and subsequently prospective study was performed among adults who took their health checkups at Zhejiang University Hospital. The participants who were free of hyperuricemia at baseline received annual follow-up examinations during a 6-year period. Cox proportional hazards regression analyses were conducted to calculate the risks for incident hyperuricemia.Of the 9238 participants enrolled, 1704 (18.4%) were diagnosed as hyperuricemia. During 21,757 person-years of follow-up, 1492 incident hyperuricemia cases were identified. The incidence of hyperuricemia was 68.58 cases per 1000 person-year of follow-up in the overall participants. The prevalence and the incidence of hyperuricemia increased greatly in female older than 50 years. High levels of BMI, SBP, FPG, TG, LDL-C, ALT, BUN, and creatinine increased the risk of hyperuricemia. Suffering fatty liver also increased the risk of hyperuricemia. Subjects with increasing DBP, TG, BUN, creatinine, or decreasing HDL-C were more likely to incident hyperuricemia.This study revealed that the change of diastolic blood pressure (DBP), serum triglycerides (TG), blood urea nitrogen (BUN), creatinine, and high-density lipoprotein cholesterol (HDL-C) level were independently associated with incident hyperuricemia. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/31626136/Risk_factors_for_the_development_of_hyperuricemia:_A_STROBE-compliant_cross-sectional_and_longitudinal_study L2 - http://dx.doi.org/10.1097/MD.0000000000017597 DB - PRIME DP - Unbound Medicine ER -