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Paraoxonase-1 and symptomatic status in carotid artery disease.

Abstract

OBJECTIVE

Paraoxonase-1 (PON-1) is a high-density-lipoprotein associated hydrolase that appears to have a protective action against atherosclerosis. The aim of our study is to identify whether PON-1 levels may be associated with the manifestation of symptoms in patients with carotid artery stenosis.

METHODS

We studied all patients who underwent carotid endarterectomy in the Vascular Surgery Department of Laikon Hospital, Athens, Greece, from July 2012 to July 2014. Medical history was recorded and PON-1 glucose, total cholesterol, high-density lipoprotein cholesterol, low-density-lipoprotein cholesterol and triglycerides levels were measured. Variables were compared between symptomatic and asymptomatic patients. A receiver operating characteristic (ROC) curve was constructed in order to evaluate accuracy of PON-1 to predict symptoms.

RESULTS

74 patients were included, 41 were asymptomatic and mean age was 68.5 years. The 2 groups appear to differ significantly with regards to the PON-1 levels, with the symptomatic group showing lower levels (5.3±1.19 vs 4.6±1.36 ng/ml; p=0.025). ROC analysis demonstrated an area under the curve of 0.654 (p=0.023).

CONCLUSION

Reduced PON-1 levels showed a significant association with symptomatic status, which was independent of other traditional cardiovascular factors. Further studies are required to prospectively assess the role of PON-1 in predicting cerebrovascular events in patients with carotid artery disease.

Authors+Show Affiliations

2(nd) Department of Surgery, "Laikon Hospital", Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: lioudakistella@hotmail.com.2(nd) Department of Surgery, "Laikon Hospital", Medical School, National and Kapodistrian University of Athens, Athens, Greece.2(nd) Department of Surgery, "Laikon Hospital", Medical School, National and Kapodistrian University of Athens, Athens, Greece.Vascular Department, University Hospital of Heraklion, Medical School, University of Crete, Heraklion, Greece.School of Health and Welfare Services, Technological Educational Institute of Crete, Heraklion, Greece.Vascular Department, University Hospital of Heraklion, Medical School, University of Crete, Heraklion, Greece.Laboratory for Experimental Surgery and Surgical Research "N.S. Christeas", Medical School, National and Kapodistrian University of Athens, Athens, Greece.Laboratory for Experimental Surgery and Surgical Research "N.S. Christeas", Medical School, National and Kapodistrian University of Athens, Athens, Greece.1(st) Department of Surgery, "Laikon Hospital", Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31626928

Citation

Lioudaki, Stella, et al. "Paraoxonase-1 and Symptomatic Status in Carotid Artery Disease." Annals of Vascular Surgery, 2019.
Lioudaki S, Verikokos C, Kouraklis G, et al. Paraoxonase-1 and symptomatic status in carotid artery disease. Ann Vasc Surg. 2019.
Lioudaki, S., Verikokos, C., Kouraklis, G., Kontopodis, N., Markakis, G., Ioannou, C., ... Klonaris, C. (2019). Paraoxonase-1 and symptomatic status in carotid artery disease. Annals of Vascular Surgery, doi:10.1016/j.avsg.2019.07.020.
Lioudaki S, et al. Paraoxonase-1 and Symptomatic Status in Carotid Artery Disease. Ann Vasc Surg. 2019 Oct 15; PubMed PMID: 31626928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paraoxonase-1 and symptomatic status in carotid artery disease. AU - Lioudaki,Stella, AU - Verikokos,Christos, AU - Kouraklis,Grigorios, AU - Kontopodis,Nikolaos, AU - Markakis,Georgios, AU - Ioannou,Christos, AU - Daskalopoulou,Aphrodite, AU - Perrea,Despina, AU - Klonaris,Christos, Y1 - 2019/10/15/ PY - 2019/06/06/received PY - 2019/07/09/revised PY - 2019/07/22/accepted PY - 2019/10/19/entrez PY - 2019/10/19/pubmed PY - 2019/10/19/medline KW - carotid KW - endarterectomy KW - paraoxonase-1 KW - stroke JF - Annals of vascular surgery JO - Ann Vasc Surg N2 - OBJECTIVE: Paraoxonase-1 (PON-1) is a high-density-lipoprotein associated hydrolase that appears to have a protective action against atherosclerosis. The aim of our study is to identify whether PON-1 levels may be associated with the manifestation of symptoms in patients with carotid artery stenosis. METHODS: We studied all patients who underwent carotid endarterectomy in the Vascular Surgery Department of Laikon Hospital, Athens, Greece, from July 2012 to July 2014. Medical history was recorded and PON-1 glucose, total cholesterol, high-density lipoprotein cholesterol, low-density-lipoprotein cholesterol and triglycerides levels were measured. Variables were compared between symptomatic and asymptomatic patients. A receiver operating characteristic (ROC) curve was constructed in order to evaluate accuracy of PON-1 to predict symptoms. RESULTS: 74 patients were included, 41 were asymptomatic and mean age was 68.5 years. The 2 groups appear to differ significantly with regards to the PON-1 levels, with the symptomatic group showing lower levels (5.3±1.19 vs 4.6±1.36 ng/ml; p=0.025). ROC analysis demonstrated an area under the curve of 0.654 (p=0.023). CONCLUSION: Reduced PON-1 levels showed a significant association with symptomatic status, which was independent of other traditional cardiovascular factors. Further studies are required to prospectively assess the role of PON-1 in predicting cerebrovascular events in patients with carotid artery disease. SN - 1615-5947 UR - https://www.unboundmedicine.com/medline/citation/31626928/Paraoxonase-1_and_symptomatic_status_in_carotid_artery_disease L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-5096(19)30768-X DB - PRIME DP - Unbound Medicine ER -