Tags

Type your tag names separated by a space and hit enter

Clinical and computed tomography features of female pelvic malignant germ cell tumors in children and adolescents: a series of 30 cases.

Abstract

STUDY OBJECTIVE

To investigate the clinical features and computed tomography (CT) findings of malignant pelvic germ cell tumors in females and improve the diagnostic level of this disease.

DESIGN

Setting, and Participants: The clinical and CT data of 30 female patients with malignant pelvic germ cell tumors confirmed by histopathology were retrospectively analyzed, prior to surgery, at a tertiary hospital. Patient's age, tumor location, clinical symptoms, tumor marker levels, and CT findings were recorded.

INTERVENTIONS

None.

MAIN OUTCOME MEASURES

Identification of the clinical features and CT findings of malignant pelvic germ cell tumors.

RESULTS

The patients ranged in age from11 months to 22 years old, with a mean age of 12.3 years.The 30 cases (30 tumors) included 10 cases of yolk sac tumor, 8 cases of dysgerminoma, and 5 cases of immature teratoma. The AFP levels were elevated in 8 cases of yolk sac tumor. Eight cases of dysgerminoma showed lobulation sign. Four cases of immature teratoma contained fat and calcification. The fibrovascular septa were observed on contrast enhanced CT in 4 cases of dysgerminoma. The "bright dot sign" was noted on contrast enhanced CT in 9 cases of yolk sac tumor. Remarkable enhancement of the solid component or septa was detected in 10 cases of yolk sac tumor. Obvious enhancement surrounding vascular bundles in the tumor was observed in 5 cases of dysgerminoma.

CONCLUSION

Malignant pelvic germ cell tumors in females frequently affect children and adolescents. The CT findings of dysgerminoma, immature teratoma, and yolk sac tumor have certain characteristic features. The combination of CT manifestations, tumor markers, and patient age helps improve the diagnostic level of this disease.

Authors+Show Affiliations

Radiology department, Qilu hospital of Shandong Universtiy Wenhua west road 107, Lixia district, Jinan city, Shandong province, China.Radiology department, Qilu hospital of Shandong Universtiy Wenhua west road 107, Lixia district, Jinan city, Shandong province, China.Radiology department, Qilu hospital of Shandong Universtiy Wenhua west road 107, Lixia district, Jinan city, Shandong province, China. Electronic address: 200062001264@sdu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31627179

Citation

Wang, Qing, et al. "Clinical and Computed Tomography Features of Female Pelvic Malignant Germ Cell Tumors in Children and Adolescents: a Series of 30 Cases." Journal of Pediatric and Adolescent Gynecology, 2019.
Wang Q, Yu D, Wang F. Clinical and computed tomography features of female pelvic malignant germ cell tumors in children and adolescents: a series of 30 cases. J Pediatr Adolesc Gynecol. 2019.
Wang, Q., Yu, D., & Wang, F. (2019). Clinical and computed tomography features of female pelvic malignant germ cell tumors in children and adolescents: a series of 30 cases. Journal of Pediatric and Adolescent Gynecology, doi:10.1016/j.jpag.2019.10.003.
Wang Q, Yu D, Wang F. Clinical and Computed Tomography Features of Female Pelvic Malignant Germ Cell Tumors in Children and Adolescents: a Series of 30 Cases. J Pediatr Adolesc Gynecol. 2019 Oct 15; PubMed PMID: 31627179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and computed tomography features of female pelvic malignant germ cell tumors in children and adolescents: a series of 30 cases. AU - Wang,Qing, AU - Yu,Dexin, AU - Wang,Fang, Y1 - 2019/10/15/ PY - 2019/07/26/received PY - 2019/10/05/revised PY - 2019/10/07/accepted PY - 2019/10/19/entrez PY - 2019/10/19/pubmed PY - 2019/10/19/medline KW - computed tomography KW - germ cell tumors KW - imaging features KW - malignant tumors KW - ovarian tumors JF - Journal of pediatric and adolescent gynecology JO - J Pediatr Adolesc Gynecol N2 - STUDY OBJECTIVE: To investigate the clinical features and computed tomography (CT) findings of malignant pelvic germ cell tumors in females and improve the diagnostic level of this disease. DESIGN: Setting, and Participants: The clinical and CT data of 30 female patients with malignant pelvic germ cell tumors confirmed by histopathology were retrospectively analyzed, prior to surgery, at a tertiary hospital. Patient's age, tumor location, clinical symptoms, tumor marker levels, and CT findings were recorded. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Identification of the clinical features and CT findings of malignant pelvic germ cell tumors. RESULTS: The patients ranged in age from11 months to 22 years old, with a mean age of 12.3 years.The 30 cases (30 tumors) included 10 cases of yolk sac tumor, 8 cases of dysgerminoma, and 5 cases of immature teratoma. The AFP levels were elevated in 8 cases of yolk sac tumor. Eight cases of dysgerminoma showed lobulation sign. Four cases of immature teratoma contained fat and calcification. The fibrovascular septa were observed on contrast enhanced CT in 4 cases of dysgerminoma. The "bright dot sign" was noted on contrast enhanced CT in 9 cases of yolk sac tumor. Remarkable enhancement of the solid component or septa was detected in 10 cases of yolk sac tumor. Obvious enhancement surrounding vascular bundles in the tumor was observed in 5 cases of dysgerminoma. CONCLUSION: Malignant pelvic germ cell tumors in females frequently affect children and adolescents. The CT findings of dysgerminoma, immature teratoma, and yolk sac tumor have certain characteristic features. The combination of CT manifestations, tumor markers, and patient age helps improve the diagnostic level of this disease. SN - 1873-4332 UR - https://www.unboundmedicine.com/medline/citation/31627179/Clinical_and_computed_tomography_features_of_female_pelvic_malignant_germ_cell_tumors_in_children_and_adolescents:_a_series_of_30_cases L2 - https://linkinghub.elsevier.com/retrieve/pii/S1083-3188(19)30320-1 DB - PRIME DP - Unbound Medicine ER -