Tags

Type your tag names separated by a space and hit enter

The Evolutionary Arms Race between Virus and NK Cells: Diversity Enables Population-Level Virus Control.
Viruses 2019; 11(10)V

Abstract

Viruses and natural killer (NK) cells have a long co-evolutionary history, evidenced by patterns of specific NK gene frequencies in those susceptible or resistant to infections. The killer immunoglobulin-like receptors (KIR) and their human leukocyte antigen (HLA) ligands together form the most polymorphic receptor-ligand partnership in the human genome and govern the process of NK cell education. The KIR and HLA genes segregate independently, thus creating an array of reactive potentials within and between the NK cell repertoires of individuals. In this review, we discuss the interplay between NK cell education and adaptation with virus infection, with a special focus on three viruses for which the NK cell response is often studied: human immunodeficiency virus (HIV), hepatitis C virus (HCV) and human cytomegalovirus (HCMV). Through this lens, we highlight the complex co-evolution of viruses and NK cells, and their impact on viral control.

Authors+Show Affiliations

Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 4R5, Canada. sarah.ka.savoy@dal.ca.Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 4R5, Canada. Jeanette.boudreau@dal.ca. Department of Pathology, Dalhousie University, Halifax, NS B3H 4R5, Canada. Jeanette.boudreau@dal.ca.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31627371

Citation

Savoy, Sarah K A., and Jeanette E. Boudreau. "The Evolutionary Arms Race Between Virus and NK Cells: Diversity Enables Population-Level Virus Control." Viruses, vol. 11, no. 10, 2019.
Savoy SKA, Boudreau JE. The Evolutionary Arms Race between Virus and NK Cells: Diversity Enables Population-Level Virus Control. Viruses. 2019;11(10).
Savoy, S. K. A., & Boudreau, J. E. (2019). The Evolutionary Arms Race between Virus and NK Cells: Diversity Enables Population-Level Virus Control. Viruses, 11(10), doi:10.3390/v11100959.
Savoy SKA, Boudreau JE. The Evolutionary Arms Race Between Virus and NK Cells: Diversity Enables Population-Level Virus Control. Viruses. 2019 Oct 17;11(10) PubMed PMID: 31627371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Evolutionary Arms Race between Virus and NK Cells: Diversity Enables Population-Level Virus Control. AU - Savoy,Sarah K A, AU - Boudreau,Jeanette E, Y1 - 2019/10/17/ PY - 2019/09/24/received PY - 2019/10/11/revised PY - 2019/10/14/accepted PY - 2019/10/20/entrez KW - HIV KW - HLA KW - KIR KW - cytomegalovirus KW - education KW - hepatitis C KW - human leukocyte antigens KW - immunogenetics KW - killer immunoglobulin-like receptors KW - licensing KW - natural killer cells KW - virus infection JF - Viruses JO - Viruses VL - 11 IS - 10 N2 - Viruses and natural killer (NK) cells have a long co-evolutionary history, evidenced by patterns of specific NK gene frequencies in those susceptible or resistant to infections. The killer immunoglobulin-like receptors (KIR) and their human leukocyte antigen (HLA) ligands together form the most polymorphic receptor-ligand partnership in the human genome and govern the process of NK cell education. The KIR and HLA genes segregate independently, thus creating an array of reactive potentials within and between the NK cell repertoires of individuals. In this review, we discuss the interplay between NK cell education and adaptation with virus infection, with a special focus on three viruses for which the NK cell response is often studied: human immunodeficiency virus (HIV), hepatitis C virus (HCV) and human cytomegalovirus (HCMV). Through this lens, we highlight the complex co-evolution of viruses and NK cells, and their impact on viral control. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/31627371/The_Evolutionary_Arms_Race_between_Virus_and_NK_Cells:_Diversity_Enables_Population-Level_Virus_Control L2 - http://www.mdpi.com/resolver?pii=v11100959 DB - PRIME DP - Unbound Medicine ER -