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Surface molecularly imprinted polymer on magnetic multi-walled carbon nanotubes for selective recognition and preconcentration of metformin in biological fluids prior to its sensitive chemiluminescence determination: Central composite design optimization.
Anal Chim Acta 2019; 1089:78-89AC

Abstract

Novel molecularly imprinted polymer (MIP) for metformin was synthesized on the surface of magnetic multi-walled carbon nanotubes (MMWCNTs) as the support. Metformin was used as the template, methacrylic acid (MAA) as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linker and 2,2'-azoisobutyronitrile (AIBN) as the initiator. The synthesized composite was characterized by field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), and Fourier transform infrared spectroscopy (FTIR). The surface molecularly imprinted composite was used for magnetic solid phase microextraction (MSPME) of metformin before its chemiluminescence (CL) determination and its capability was compared with non-imprinted polymer (NIP). The central composite design was used for optimization as well as consideration of possible interaction of effective variables on extraction. Under the optimized conditions, the developed method exhibited the linear dynamic range of 0.5-50.0 μg L-1 with a detection limit of 0.13 μg L-1 and enhancement factor of 195.3 for the preconcentration of 100 mL of the sample and 500 μL of an eluent. The intra- and inter-day relative standard deviations (RSD%) at 5.0 μg L-1 level of metformin (n = 6) were 3.7 and 4.9%, respectively. The maximum adsorption capacity of the sorbent was found to be 80.0 mg g-1, the adsorption of metformin was endothermic and spontaneous and followed the Langmuir isotherm model. The adsorption kinetic was also found to be best fitted with the pseudo-second-order model. The designed method was successfully applied to the extraction and determination of metformin in biological fluids and water samples.

Authors+Show Affiliations

Department of Chemistry, Yazd University, 89195-741, Yazd, Iran.Department of Chemistry, Yazd University, 89195-741, Yazd, Iran. Electronic address: sdadfarnia@yazd.ac.ir.Department of Chemistry, Yazd University, 89195-741, Yazd, Iran. Electronic address: hshabani@yazd.ac.ir.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31627821

Citation

Toudeshki, Reza Mohammadi, et al. "Surface Molecularly Imprinted Polymer On Magnetic Multi-walled Carbon Nanotubes for Selective Recognition and Preconcentration of Metformin in Biological Fluids Prior to Its Sensitive Chemiluminescence Determination: Central Composite Design Optimization." Analytica Chimica Acta, vol. 1089, 2019, pp. 78-89.
Toudeshki RM, Dadfarnia S, Haji Shabani AM. Surface molecularly imprinted polymer on magnetic multi-walled carbon nanotubes for selective recognition and preconcentration of metformin in biological fluids prior to its sensitive chemiluminescence determination: Central composite design optimization. Anal Chim Acta. 2019;1089:78-89.
Toudeshki, R. M., Dadfarnia, S., & Haji Shabani, A. M. (2019). Surface molecularly imprinted polymer on magnetic multi-walled carbon nanotubes for selective recognition and preconcentration of metformin in biological fluids prior to its sensitive chemiluminescence determination: Central composite design optimization. Analytica Chimica Acta, 1089, pp. 78-89. doi:10.1016/j.aca.2019.08.070.
Toudeshki RM, Dadfarnia S, Haji Shabani AM. Surface Molecularly Imprinted Polymer On Magnetic Multi-walled Carbon Nanotubes for Selective Recognition and Preconcentration of Metformin in Biological Fluids Prior to Its Sensitive Chemiluminescence Determination: Central Composite Design Optimization. Anal Chim Acta. 2019 Dec 16;1089:78-89. PubMed PMID: 31627821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surface molecularly imprinted polymer on magnetic multi-walled carbon nanotubes for selective recognition and preconcentration of metformin in biological fluids prior to its sensitive chemiluminescence determination: Central composite design optimization. AU - Toudeshki,Reza Mohammadi, AU - Dadfarnia,Shayessteh, AU - Haji Shabani,Ali Mohammad, Y1 - 2019/09/24/ PY - 2019/07/03/received PY - 2019/08/27/revised PY - 2019/08/30/accepted PY - 2019/10/20/entrez KW - Chemiluminescence determination KW - Magnetic multi-walled carbon nanotubes KW - Magnetic solid phase microextraction KW - Metformin KW - Molecularly imprinted polymer SP - 78 EP - 89 JF - Analytica chimica acta JO - Anal. Chim. Acta VL - 1089 N2 - Novel molecularly imprinted polymer (MIP) for metformin was synthesized on the surface of magnetic multi-walled carbon nanotubes (MMWCNTs) as the support. Metformin was used as the template, methacrylic acid (MAA) as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linker and 2,2'-azoisobutyronitrile (AIBN) as the initiator. The synthesized composite was characterized by field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), and Fourier transform infrared spectroscopy (FTIR). The surface molecularly imprinted composite was used for magnetic solid phase microextraction (MSPME) of metformin before its chemiluminescence (CL) determination and its capability was compared with non-imprinted polymer (NIP). The central composite design was used for optimization as well as consideration of possible interaction of effective variables on extraction. Under the optimized conditions, the developed method exhibited the linear dynamic range of 0.5-50.0 μg L-1 with a detection limit of 0.13 μg L-1 and enhancement factor of 195.3 for the preconcentration of 100 mL of the sample and 500 μL of an eluent. The intra- and inter-day relative standard deviations (RSD%) at 5.0 μg L-1 level of metformin (n = 6) were 3.7 and 4.9%, respectively. The maximum adsorption capacity of the sorbent was found to be 80.0 mg g-1, the adsorption of metformin was endothermic and spontaneous and followed the Langmuir isotherm model. The adsorption kinetic was also found to be best fitted with the pseudo-second-order model. The designed method was successfully applied to the extraction and determination of metformin in biological fluids and water samples. SN - 1873-4324 UR - https://www.unboundmedicine.com/medline/citation/31627821/Surface_molecularly_imprinted_polymer_on_magnetic_multi-walled_carbon_nanotubes_for_selective_recognition_and_preconcentration_of_metformin_in_biological_fluids_prior_to_its_sensitive_chemiluminescence_determination:_Central_composite_design_optimization L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-2670(19)31037-2 DB - PRIME DP - Unbound Medicine ER -