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Fournier's Gangrene in a Patient with Type 2 Diabetes Mellitus Treated with Empagliflozin: A Case Report.
Drug Saf Case Rep 2019; 6(1):11DS

Abstract

Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been reported as possibly associated with Fournier's gangrene (FG). This case report describes a 34-year-old Japanese man who was diagnosed with FG after the administration of empagliflozin for type 2 diabetes mellitus (T2DM). He presented with pain and swelling in the perineum and groin 142 days after initiating empagliflozin. The clinical features, laboratory data, and computed tomographic findings were consistent with FG. Surgical drainage and debridement of necrotic tissues were performed immediately after admission to our hospital. The patient had no complications of diabetes before the onset of FG. Glycemic management was good at the time of FG onset. This case suggests a possible association between empagliflozin and FG. We report a case of FG in a patient during a period of good glycemic management following treatment with empagliflozin. We recommend further awareness of this relationship and suggest the need for additional research.

Authors+Show Affiliations

Department of Pharmacy, Sanraku Hospital, 2-5 Kandasurugadai, Chiyoda-ku, Tokyo, 1018326, Japan. nagano8931@sanraku.or.jp.Department of Pharmacy, Sanraku Hospital, 2-5 Kandasurugadai, Chiyoda-ku, Tokyo, 1018326, Japan.Department of Surgery, Sanraku Hospital, 2-5 Kandasurugadai, Chiyoda-ku, Tokyo, 1018326, Japan.Department of Endocrinology and Metabolism, Sanraku Hospital, 2-5 Kandasurugadai, Chiyoda-ku, Tokyo, 1018326, Japan.Department of Surgery, Sanraku Hospital, 2-5 Kandasurugadai, Chiyoda-ku, Tokyo, 1018326, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31628552

Citation

Nagano, Yasunori, et al. "Fournier's Gangrene in a Patient With Type 2 Diabetes Mellitus Treated With Empagliflozin: a Case Report." Drug Safety - Case Reports, vol. 6, no. 1, 2019, p. 11.
Nagano Y, Yakame NK, Aoki H, et al. Fournier's Gangrene in a Patient with Type 2 Diabetes Mellitus Treated with Empagliflozin: A Case Report. Drug Saf Case Rep. 2019;6(1):11.
Nagano, Y., Yakame, N. K., Aoki, H., Yamakawa, T., & Kondo, N. I. (2019). Fournier's Gangrene in a Patient with Type 2 Diabetes Mellitus Treated with Empagliflozin: A Case Report. Drug Safety - Case Reports, 6(1), p. 11. doi:10.1007/s40800-019-0105-8.
Nagano Y, et al. Fournier's Gangrene in a Patient With Type 2 Diabetes Mellitus Treated With Empagliflozin: a Case Report. Drug Saf Case Rep. 2019 Oct 18;6(1):11. PubMed PMID: 31628552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fournier's Gangrene in a Patient with Type 2 Diabetes Mellitus Treated with Empagliflozin: A Case Report. AU - Nagano,Yasunori, AU - Yakame,Naomi Kashiwagi, AU - Aoki,Hisae, AU - Yamakawa,Tamaki, AU - Kondo,Naoko Iwahashi, Y1 - 2019/10/18/ PY - 2019/10/20/entrez PY - 2019/10/20/pubmed PY - 2019/10/20/medline SP - 11 EP - 11 JF - Drug safety - case reports JO - Drug Saf Case Rep VL - 6 IS - 1 N2 - Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been reported as possibly associated with Fournier's gangrene (FG). This case report describes a 34-year-old Japanese man who was diagnosed with FG after the administration of empagliflozin for type 2 diabetes mellitus (T2DM). He presented with pain and swelling in the perineum and groin 142 days after initiating empagliflozin. The clinical features, laboratory data, and computed tomographic findings were consistent with FG. Surgical drainage and debridement of necrotic tissues were performed immediately after admission to our hospital. The patient had no complications of diabetes before the onset of FG. Glycemic management was good at the time of FG onset. This case suggests a possible association between empagliflozin and FG. We report a case of FG in a patient during a period of good glycemic management following treatment with empagliflozin. We recommend further awareness of this relationship and suggest the need for additional research. SN - 2199-1162 UR - https://www.unboundmedicine.com/medline/citation/31628552/Fournier's_Gangrene_in_a_Patient_with_Type_2_Diabetes_Mellitus_Treated_with_Empagliflozin:_A_Case_Report L2 - https://link.springer.com/article/10.1007/s40800-019-0105-8 DB - PRIME DP - Unbound Medicine ER -