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Prognostic value of 18F-FDG PET/MR imaging biomarkers in oesophageal squamous cell carcinoma.
Eur J Radiol 2019; 120:108671EJ

Abstract

PURPOSE

To correlate the clinical stage and prognosis of oesophageal squamous cell carcinoma (SCC) using the imaging biomarkers from integrated positron emission tomography (PET)/magnetic resonance imaging (MRI).

METHODS

In total, 54 consecutive patients with oesophageal SCC who receive PET/MRI scan were recruited before treatment. The imaging biomarkers used were the mean and minimal apparent diffusion coefficients (ADCmean and ADCmin), standardized uptake value (SUV), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) of tumours. The correlation between each imaging biomarker and survival was investigated using the Cox proportional hazards model.

RESULTS

ADCmean was negatively correlated with SUVmax (r = -0.414, P = 0.025). ADCmin was negatively correlated with SUVmax (r = -0.423, P = 0.001) and SUVpeak (r = -0.402, P = 0.003), and was significantly lower in M1 than in M0 tumours (829.6 vs. 1069.8, P = 0.005). MTV was significantly higher in T3 + (P < 0.001), N1 + (P = 0.014) and TNM stage III + (P < 0.001) tumours. TLG was significantly higher in T3 + (P < 0.001), N1 + (P < 0.001), M1 (P = 0.045) and TNM stage III + (P < 0.001) tumours. The MTV/ADCmin ratio exhibited the highest area under the receiver operating characteristic curve (AUROC) for predicting M1 and advanced TNM stage tumours. Multivariate analysis for progression-free survival (PFS) and overall survival (OS) showed that a larger MTV/ADCmin was associated with a shorter PFS and OS (P = 0.024 and 0.046, respectively).

CONCLUSION

The imaging biomarkers in integrated PET/MRI may predict clinical stage and survival in patients with oesophageal SCC.

Authors+Show Affiliations

Department of Radiology and Medical Imaging, National Taiwan University College of Medicine and Hospital, No. 7, Chung-Shan South Rd, Taipei 10016, Taiwan.Department of Medical Imaging, Sin-Lau Medical Foundation the Presbyterian Church in Taiwan, No. 57, Sec. 1, Dongmen Rd., East Dist., Tainan 70142, Taiwan.Department of Radiology and Medical Imaging, National Taiwan University College of Medicine and Hospital, No. 7, Chung-Shan South Rd, Taipei 10016, Taiwan.Department of Medical Imaging, Cardinal Tien Hospital, No. 362, Zhongzheng Rd., Xindian Dist., New Taipei City 23148, Taiwan.Department of Nuclear Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Rd., Taipei 10016, Taiwan.Department of Radiology and Medical Imaging, National Taiwan University College of Medicine and Hospital, No. 7, Chung-Shan South Rd, Taipei 10016, Taiwan.Department of Radiology and Medical Imaging, National Taiwan University College of Medicine and Hospital, No. 7, Chung-Shan South Rd, Taipei 10016, Taiwan.Department of Surgery, National Taiwan University College of Medicine and Hospital, No. 7, Chung-Shan South Rd., Taipei 10016, Taiwan. Electronic address: jmlee@ntu.edu.tw.Department of Radiology and Medical Imaging, National Taiwan University College of Medicine and Hospital, No. 7, Chung-Shan South Rd, Taipei 10016, Taiwan. Electronic address: ttfshih@ntu.edu.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31629121

Citation

Yu, Chih-Wei, et al. "Prognostic Value of 18F-FDG PET/MR Imaging Biomarkers in Oesophageal Squamous Cell Carcinoma." European Journal of Radiology, vol. 120, 2019, p. 108671.
Yu CW, Chen XJ, Lin YH, et al. Prognostic value of 18F-FDG PET/MR imaging biomarkers in oesophageal squamous cell carcinoma. Eur J Radiol. 2019;120:108671.
Yu, C. W., Chen, X. J., Lin, Y. H., Tseng, Y. H., Lu, C. C., Chen, B. B., ... Shih, T. T. (2019). Prognostic value of 18F-FDG PET/MR imaging biomarkers in oesophageal squamous cell carcinoma. European Journal of Radiology, 120, p. 108671. doi:10.1016/j.ejrad.2019.108671.
Yu CW, et al. Prognostic Value of 18F-FDG PET/MR Imaging Biomarkers in Oesophageal Squamous Cell Carcinoma. Eur J Radiol. 2019;120:108671. PubMed PMID: 31629121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic value of 18F-FDG PET/MR imaging biomarkers in oesophageal squamous cell carcinoma. AU - Yu,Chih-Wei, AU - Chen,Xin-Jia, AU - Lin,Yen-Heng, AU - Tseng,Yao-Hui, AU - Lu,Ching-Chu, AU - Chen,Bang-Bin, AU - Wei,Shwu-Yuan, AU - Lee,Jang-Ming, AU - Shih,Tiffany Ting-Fang, Y1 - 2019/09/30/ PY - 2019/03/18/received PY - 2019/09/05/revised PY - 2019/09/12/accepted PY - 2019/10/20/pubmed PY - 2019/10/20/medline PY - 2019/10/20/entrez KW - Diffusion-weighted imaging KW - Magnetic resonance imaging KW - Oesophageal carcinoma KW - Overall survival KW - Positron emission tomography KW - Progression-free survival SP - 108671 EP - 108671 JF - European journal of radiology JO - Eur J Radiol VL - 120 N2 - PURPOSE: To correlate the clinical stage and prognosis of oesophageal squamous cell carcinoma (SCC) using the imaging biomarkers from integrated positron emission tomography (PET)/magnetic resonance imaging (MRI). METHODS: In total, 54 consecutive patients with oesophageal SCC who receive PET/MRI scan were recruited before treatment. The imaging biomarkers used were the mean and minimal apparent diffusion coefficients (ADCmean and ADCmin), standardized uptake value (SUV), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) of tumours. The correlation between each imaging biomarker and survival was investigated using the Cox proportional hazards model. RESULTS: ADCmean was negatively correlated with SUVmax (r = -0.414, P = 0.025). ADCmin was negatively correlated with SUVmax (r = -0.423, P = 0.001) and SUVpeak (r = -0.402, P = 0.003), and was significantly lower in M1 than in M0 tumours (829.6 vs. 1069.8, P = 0.005). MTV was significantly higher in T3 + (P < 0.001), N1 + (P = 0.014) and TNM stage III + (P < 0.001) tumours. TLG was significantly higher in T3 + (P < 0.001), N1 + (P < 0.001), M1 (P = 0.045) and TNM stage III + (P < 0.001) tumours. The MTV/ADCmin ratio exhibited the highest area under the receiver operating characteristic curve (AUROC) for predicting M1 and advanced TNM stage tumours. Multivariate analysis for progression-free survival (PFS) and overall survival (OS) showed that a larger MTV/ADCmin was associated with a shorter PFS and OS (P = 0.024 and 0.046, respectively). CONCLUSION: The imaging biomarkers in integrated PET/MRI may predict clinical stage and survival in patients with oesophageal SCC. SN - 1872-7727 UR - https://www.unboundmedicine.com/medline/citation/31629121/Prognostic_value_of_18F-FDG_PET/MR_imaging_biomarkers_in_oesophageal_squamous_cell_carcinoma L2 - https://linkinghub.elsevier.com/retrieve/pii/S0720-048X(19)30321-3 DB - PRIME DP - Unbound Medicine ER -