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Dynamic expression of autophagy-related factors in autoimmune encephalomyelitis and exploration of curcumin therapy.
J Neuroimmunol 2019; 337:577067JN

Abstract

Curcumin has been used in the study of central nervous system immune-related diseases and exerts a substantial neuroprotective effect. However, the mechanism remains unclear. The AKT/mTOR autophagy-related signalling pathway plays an important role in tumour therapy, but whether curcumin plays a therapeutic role in multiple sclerosis (MS) through this signalling pathway remains to be determined. As an animal model of MS, experimental autoimmune encephalomyelitis (EAE) is induced by the myelin glial glycoprotein MOG35-55 in female C57BL/6 mice. We first evaluated the changes in autophagy levels in EAE mice. Then, curcumin was intraperitoneally injected into the mice, and the expression of AKT/mTOR autophagy signalling pathway-related proteins was evaluated. Our data show that 1. autophagy defects can cause neuronal damage in EAE mice; and 2. curcumin may regulate the activation of autophagy in EAE mice by affecting the AKT/mTOR autophagy signalling pathway, further balancing central nervous system and peripheral autophagy.

Authors+Show Affiliations

Neurology Department, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China.Neurology Department, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China.Neurology Department, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China.Neurology Department, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China.Department of Gastrointestinal Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou 563003, China.Neurology Department, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China. Electronic address: wmx322@aliyun.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31629984

Citation

Boyao, Yuan, et al. "Dynamic Expression of Autophagy-related Factors in Autoimmune Encephalomyelitis and Exploration of Curcumin Therapy." Journal of Neuroimmunology, vol. 337, 2019, p. 577067.
Boyao Y, Mengjiao S, Caicai B, et al. Dynamic expression of autophagy-related factors in autoimmune encephalomyelitis and exploration of curcumin therapy. J Neuroimmunol. 2019;337:577067.
Boyao, Y., Mengjiao, S., Caicai, B., Xiaoling, L., Zhenxing, L., & Manxia, W. (2019). Dynamic expression of autophagy-related factors in autoimmune encephalomyelitis and exploration of curcumin therapy. Journal of Neuroimmunology, 337, p. 577067. doi:10.1016/j.jneuroim.2019.577067.
Boyao Y, et al. Dynamic Expression of Autophagy-related Factors in Autoimmune Encephalomyelitis and Exploration of Curcumin Therapy. J Neuroimmunol. 2019 Dec 15;337:577067. PubMed PMID: 31629984.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dynamic expression of autophagy-related factors in autoimmune encephalomyelitis and exploration of curcumin therapy. AU - Boyao,Yuan, AU - Mengjiao,Sun, AU - Caicai,Bao, AU - Xiaoling,Li, AU - Zhenxing,Liu, AU - Manxia,Wang, Y1 - 2019/09/13/ PY - 2018/10/28/received PY - 2019/02/17/revised PY - 2019/09/10/accepted PY - 2019/10/21/pubmed PY - 2019/10/21/medline PY - 2019/10/21/entrez KW - Autophagy KW - Curcumin KW - Experimental autoimmune encephalomyelitis (EAE) KW - Multiple sclerosis KW - mTOR SP - 577067 EP - 577067 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 337 N2 - Curcumin has been used in the study of central nervous system immune-related diseases and exerts a substantial neuroprotective effect. However, the mechanism remains unclear. The AKT/mTOR autophagy-related signalling pathway plays an important role in tumour therapy, but whether curcumin plays a therapeutic role in multiple sclerosis (MS) through this signalling pathway remains to be determined. As an animal model of MS, experimental autoimmune encephalomyelitis (EAE) is induced by the myelin glial glycoprotein MOG35-55 in female C57BL/6 mice. We first evaluated the changes in autophagy levels in EAE mice. Then, curcumin was intraperitoneally injected into the mice, and the expression of AKT/mTOR autophagy signalling pathway-related proteins was evaluated. Our data show that 1. autophagy defects can cause neuronal damage in EAE mice; and 2. curcumin may regulate the activation of autophagy in EAE mice by affecting the AKT/mTOR autophagy signalling pathway, further balancing central nervous system and peripheral autophagy. SN - 1872-8421 UR - https://www.unboundmedicine.com/medline/citation/31629984/Dynamic_expression_of_autophagy-related_factors_in_autoimmune_encephalomyelitis_and_exploration_of_curcumin_therapy L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(18)30480-6 DB - PRIME DP - Unbound Medicine ER -