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Minocycline induces the expression of intra-accumbal glutamate transporter-1 in the morphine-dependent rats.
Asian J Psychiatr 2019; 46:70-73AJ

Abstract

Glial glutamate transporters (GLT-1) is responsible for glutamate homeostasis. GLT-1 expression and glutamate uptake can be affected by addictive drugs and can be used as a target in addiction pharmacotherapy. It has been shown that minocycline, an antibiotic with anti-inflammatory, and neuroprotective properties, can upregulate the expression of GLT-1. In the present study, in morphine-dependent rats, the effect of minocycline on expression of GLT-1 in nucleus accumbens was investigated by immunohistochemistry. The expression of GLT-1 significantly increased in minocycline treated animals. In line with other studies, our findings showed that restoring GLT-1 expression with minocycline might be considered as a potential target for correcting pre-clinical and clinical manifestations of drug addiction.

Authors+Show Affiliations

Addiction Department, School of Behavioral Sciences and Mental Health (Tehran Institute of Psychiatry), Iran University of Medical Sciences, Tehran, Iran; Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Neuroscience Lab, Biology and Anatomical Sciences Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: Haghparast@sbmu.ac.ir.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31630007

Citation

Arezoomandan, Reza, et al. "Minocycline Induces the Expression of Intra-accumbal Glutamate Transporter-1 in the Morphine-dependent Rats." Asian Journal of Psychiatry, vol. 46, 2019, pp. 70-73.
Arezoomandan R, Aliaghaei A, Khodagholi F, et al. Minocycline induces the expression of intra-accumbal glutamate transporter-1 in the morphine-dependent rats. Asian J Psychiatr. 2019;46:70-73.
Arezoomandan, R., Aliaghaei, A., Khodagholi, F., & Haghparast, A. (2019). Minocycline induces the expression of intra-accumbal glutamate transporter-1 in the morphine-dependent rats. Asian Journal of Psychiatry, 46, pp. 70-73. doi:10.1016/j.ajp.2019.10.007.
Arezoomandan R, et al. Minocycline Induces the Expression of Intra-accumbal Glutamate Transporter-1 in the Morphine-dependent Rats. Asian J Psychiatr. 2019 Oct 12;46:70-73. PubMed PMID: 31630007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Minocycline induces the expression of intra-accumbal glutamate transporter-1 in the morphine-dependent rats. AU - Arezoomandan,Reza, AU - Aliaghaei,Abbas, AU - Khodagholi,Fariba, AU - Haghparast,Abbas, Y1 - 2019/10/12/ PY - 2019/07/27/received PY - 2019/10/06/revised PY - 2019/10/07/accepted PY - 2019/10/21/pubmed PY - 2019/10/21/medline PY - 2019/10/21/entrez KW - Glutamate transporter 1 KW - Immunohistochemistry KW - Minocycline KW - Morphine dependency KW - Nucleus accumbens KW - Rat SP - 70 EP - 73 JF - Asian journal of psychiatry JO - Asian J Psychiatr VL - 46 N2 - Glial glutamate transporters (GLT-1) is responsible for glutamate homeostasis. GLT-1 expression and glutamate uptake can be affected by addictive drugs and can be used as a target in addiction pharmacotherapy. It has been shown that minocycline, an antibiotic with anti-inflammatory, and neuroprotective properties, can upregulate the expression of GLT-1. In the present study, in morphine-dependent rats, the effect of minocycline on expression of GLT-1 in nucleus accumbens was investigated by immunohistochemistry. The expression of GLT-1 significantly increased in minocycline treated animals. In line with other studies, our findings showed that restoring GLT-1 expression with minocycline might be considered as a potential target for correcting pre-clinical and clinical manifestations of drug addiction. SN - 1876-2026 UR - https://www.unboundmedicine.com/medline/citation/31630007/Minocycline_induces_the_expression_of_intra-accumbal_glutamate_transporter-1_in_the_morphine-dependent_rats L2 - https://linkinghub.elsevier.com/retrieve/pii/S1876-2018(19)30559-3 DB - PRIME DP - Unbound Medicine ER -