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Neuro-Immuno-Endocrine Interactions in Early Life Stress and Heroin Withdrawal Timeline.
Eur Addict Res 2019; :1-12EA

Abstract

Both heroin abuse and early life stress (ELS) affect the immune system and the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, accelerated aging due to mild inflammation has been indicated in these conditions. The present study aims to compare plasma levels of apoptosis markers, inflammatory markers, and stress hormones during early heroin abstinence period. Thirty-one individuals with heroin/opioid use disorder who had heroin-ELS and 26 of their siblings who were not abusing substances (ELS), and 32 individuals with heroin/opioid use disorder without a history of ELS (heroin-no ELS) were included in the study. The levels of interleukin-6, C-reactive protein, erythrocyte sedimentation rate, albumin, alanine transaminase, aspartate transaminase, and white blood cell count were assessed as the inflammatory and biochemistry markers. Also, apoptosis markers including tumor necrosis factor (TNF)-related weak inducer of apoptosis, TNF-related apoptosis-inducing ligand, soluble tumor necrosis factor receptor type I as apoptosis markers were detected by enzyme-linked immunosorbent assay. ELS was simultaneously evaluated using the Childhood Trauma Questionnaire, Minnesota Multiphasic Personality Inventory, and beck depression inventory scales. Besides, heroin craving was assessed by Daily Drinking/Drug Questionnaire score in individuals with heroin use disorder. This is the first study to evaluate the inflammatory, stress, and apoptosis markers during heroin abstinence, supporting the association between ELS and peripheral pro-inflammatory markers' levels and HPA axis.

Authors+Show Affiliations

Department of Addiction Studies, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. Physiology Research Center, Kashan University of Medical Sciences, kashan, Iran.Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran, nafesm5@gmail.com.Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran.Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Addiction Studies, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. Physiology Research Center, Kashan University of Medical Sciences, kashan, Iran. Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, kashan, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31630140

Citation

Moeini, Mina, et al. "Neuro-Immuno-Endocrine Interactions in Early Life Stress and Heroin Withdrawal Timeline." European Addiction Research, 2019, pp. 1-12.
Moeini M, Esmaeil N, Mokhtari HR, et al. Neuro-Immuno-Endocrine Interactions in Early Life Stress and Heroin Withdrawal Timeline. Eur Addict Res. 2019.
Moeini, M., Esmaeil, N., Mokhtari, H. R., Eskandari, N., & Banafshe, H. R. (2019). Neuro-Immuno-Endocrine Interactions in Early Life Stress and Heroin Withdrawal Timeline. European Addiction Research, pp. 1-12. doi:10.1159/000503880.
Moeini M, et al. Neuro-Immuno-Endocrine Interactions in Early Life Stress and Heroin Withdrawal Timeline. Eur Addict Res. 2019 Oct 18;1-12. PubMed PMID: 31630140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuro-Immuno-Endocrine Interactions in Early Life Stress and Heroin Withdrawal Timeline. AU - Moeini,Mina, AU - Esmaeil,Nafiseh, AU - Mokhtari,Hamid Reza, AU - Eskandari,Nahid, AU - Banafshe,Hamid Reza, Y1 - 2019/10/18/ PY - 2019/02/27/received PY - 2019/10/03/accepted PY - 2019/10/21/entrez PY - 2019/10/21/pubmed PY - 2019/10/21/medline KW - Apoptosis KW - Early life stress KW - Heroin abuse KW - Hypothalamic-pituitary-adrenal axis KW - Inflammation SP - 1 EP - 12 JF - European addiction research JO - Eur Addict Res N2 - Both heroin abuse and early life stress (ELS) affect the immune system and the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, accelerated aging due to mild inflammation has been indicated in these conditions. The present study aims to compare plasma levels of apoptosis markers, inflammatory markers, and stress hormones during early heroin abstinence period. Thirty-one individuals with heroin/opioid use disorder who had heroin-ELS and 26 of their siblings who were not abusing substances (ELS), and 32 individuals with heroin/opioid use disorder without a history of ELS (heroin-no ELS) were included in the study. The levels of interleukin-6, C-reactive protein, erythrocyte sedimentation rate, albumin, alanine transaminase, aspartate transaminase, and white blood cell count were assessed as the inflammatory and biochemistry markers. Also, apoptosis markers including tumor necrosis factor (TNF)-related weak inducer of apoptosis, TNF-related apoptosis-inducing ligand, soluble tumor necrosis factor receptor type I as apoptosis markers were detected by enzyme-linked immunosorbent assay. ELS was simultaneously evaluated using the Childhood Trauma Questionnaire, Minnesota Multiphasic Personality Inventory, and beck depression inventory scales. Besides, heroin craving was assessed by Daily Drinking/Drug Questionnaire score in individuals with heroin use disorder. This is the first study to evaluate the inflammatory, stress, and apoptosis markers during heroin abstinence, supporting the association between ELS and peripheral pro-inflammatory markers' levels and HPA axis. SN - 1421-9891 UR - https://www.unboundmedicine.com/medline/citation/31630140/Neuro-Immuno-Endocrine_Interactions_in_Early_Life_Stress_and_Heroin_Withdrawal_Timeline L2 - https://www.karger.com?DOI=10.1159/000503880 DB - PRIME DP - Unbound Medicine ER -