Tags

Type your tag names separated by a space and hit enter

Conventional and High-Sensitivity Malaria Rapid Diagnostic Test Performance in Two Transmission Settings: Haiti 2017.

Abstract

Accurate malaria diagnosis is foundational for control and elimination, and Haiti relies on HRP2-based rapid diagnostic tests (RDTs) identifying Plasmodium falciparum in clinical and community settings. In 2017, one household and two easy-access group (EAG) surveys tested all participants (N=32,506) by conventional and high-sensitivity RDTs (cRDT/hsRDT). A subset of blood samples (n=1,154) were laboratory tested for HRP2 by bead-based immunoassay and for P. falciparum 18S rDNA by PET-PCR. Both RDT types detected low concentrations of HRP2 with sensitivity estimates between 2.6 and 14.6 ng/mL. Compared to the predicate HRP2 laboratory assay,, RDT sensitivity ranged from 86.3% to 96.0% between tests and settings, and specificity from 90.0% to 99.6%. In the household survey, the hsRDT provided a significantly higher number of positive tests, but this represented a very small proportion (<0.2%) of all participants. These data show an hsRDT may have limited utility in a malaria elimination setting like Haiti.

Authors+Show Affiliations

Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA.Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA.Center for Applied Malaria Research and Evaluation, Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans LA.Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA.Laboratorie National de Santé Publique (LNSP), Ministère de la Santé Publique et de la Population (MSPP), Port-au-Prince, Haiti.Laboratorie National de Santé Publique (LNSP), Ministère de la Santé Publique et de la Population (MSPP), Port-au-Prince, Haiti.Laboratorie National de Santé Publique (LNSP), Ministère de la Santé Publique et de la Population (MSPP), Port-au-Prince, Haiti.Laboratorie National de Santé Publique (LNSP), Ministère de la Santé Publique et de la Population (MSPP), Port-au-Prince, Haiti.Department of Immunology & Infection, London School of Hygiene & Tropical Medicine, London, UK.Programme National de Contrôle de la Malaria, Ministère de la Santé Publique et de la Population (MSPP), Port-au-Prince, Haiti.Department of Immunology & Infection, London School of Hygiene & Tropical Medicine, London, UK.Center for Applied Malaria Research and Evaluation, Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans LA.Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA.Laboratorie National de Santé Publique (LNSP), Ministère de la Santé Publique et de la Population (MSPP), Port-au-Prince, Haiti.Laboratorie National de Santé Publique (LNSP), Ministère de la Santé Publique et de la Population (MSPP), Port-au-Prince, Haiti.Department of Immunology & Infection, London School of Hygiene & Tropical Medicine, London, UK.Center for Applied Malaria Research and Evaluation, Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans LA. Department of Social and Preventive Medicine, University of Montreal School of Public Health, Montreal QC.Center for Applied Malaria Research and Evaluation, Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans LA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31630194

Citation

Rogier, Eric, et al. "Conventional and High-Sensitivity Malaria Rapid Diagnostic Test Performance in Two Transmission Settings: Haiti 2017." The Journal of Infectious Diseases, 2019.
Rogier E, Hamre KES, Joseph V, et al. Conventional and High-Sensitivity Malaria Rapid Diagnostic Test Performance in Two Transmission Settings: Haiti 2017. J Infect Dis. 2019.
Rogier, E., Hamre, K. E. S., Joseph, V., Plucinski, M. M., Presume, J., Romilus, I., ... Eisele, T. P. (2019). Conventional and High-Sensitivity Malaria Rapid Diagnostic Test Performance in Two Transmission Settings: Haiti 2017. The Journal of Infectious Diseases, doi:10.1093/infdis/jiz525.
Rogier E, et al. Conventional and High-Sensitivity Malaria Rapid Diagnostic Test Performance in Two Transmission Settings: Haiti 2017. J Infect Dis. 2019 Oct 21; PubMed PMID: 31630194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Conventional and High-Sensitivity Malaria Rapid Diagnostic Test Performance in Two Transmission Settings: Haiti 2017. AU - Rogier,Eric, AU - Hamre,Karen E S, AU - Joseph,Vena, AU - Plucinski,Mateusz M, AU - Presume,Jacquelin, AU - Romilus,Ithamare, AU - Mondelus,Gina, AU - Elisme,Tamara, AU - van den Hoogen,Lotus, AU - Lemoine,Jean Frantz, AU - Drakeley,Chris, AU - Ashton,Ruth A, AU - Chang,Michelle A, AU - Existe,Alexandre, AU - Boncy,Jacques, AU - Stresman,Gillian, AU - Druetz,Thomas, AU - Eisele,Thomas P, Y1 - 2019/10/21/ PY - 2019/08/01/received PY - 2019/10/21/entrez PY - 2019/10/21/pubmed PY - 2019/10/21/medline KW - Plasmodium falciparum KW - HRP2 KW - Haiti KW - malaria elimination KW - rapid diagnostic test JF - The Journal of infectious diseases JO - J. Infect. Dis. N2 - Accurate malaria diagnosis is foundational for control and elimination, and Haiti relies on HRP2-based rapid diagnostic tests (RDTs) identifying Plasmodium falciparum in clinical and community settings. In 2017, one household and two easy-access group (EAG) surveys tested all participants (N=32,506) by conventional and high-sensitivity RDTs (cRDT/hsRDT). A subset of blood samples (n=1,154) were laboratory tested for HRP2 by bead-based immunoassay and for P. falciparum 18S rDNA by PET-PCR. Both RDT types detected low concentrations of HRP2 with sensitivity estimates between 2.6 and 14.6 ng/mL. Compared to the predicate HRP2 laboratory assay,, RDT sensitivity ranged from 86.3% to 96.0% between tests and settings, and specificity from 90.0% to 99.6%. In the household survey, the hsRDT provided a significantly higher number of positive tests, but this represented a very small proportion (<0.2%) of all participants. These data show an hsRDT may have limited utility in a malaria elimination setting like Haiti. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/31630194/Conventional_and_High-Sensitivity_Malaria_Rapid_Diagnostic_Test_Performance_in_Two_Transmission_Settings:_Haiti_2017 L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiz525 DB - PRIME DP - Unbound Medicine ER -