Tags

Type your tag names separated by a space and hit enter

Association between serum vitamin D levels and benign paroxysmal positional vertigo: a systematic review and meta-analysis of observational studies.

Abstract

OBJECTIVE

Benign paroxysmal positional vertigo (BPPV) was the most common neuro-otological disorder manifests as recurrent positional vertigo, but its risk factors are elusive. Recent studies suggest that decreased Vitamin D level may be a risk factor, but the literature is inconsistent.

METHODS

The databases PubMed, Web of Science, Chinese National Knowledge Infrastructure, Wanfang, SinoMed, and Embase were systematically searched for studies on the association between BPPV and serum Vitamin D levels published up to June 2019. Data from eligible studies were meta-analyzed using Stata 12.0.

RESULTS

A total of 18 studies were included in the analysis. Serum Vitamin D levels were significantly lower in individuals with BPPV than in controls (WMD - 2.46, 95% CI - 3.79 to - 1.12, p < 0.001). Subgroup analysis by geographical area showed that vitamin D level was significantly lower in BPPV than in controls in China (WMD - 3.27, 95% CI - 4.12 to - 2.43, p < 0.001), but not outside China (WMD - 0.90, 95% CI - 4.36 to 2.56, p = 0.611). Vitamin D levels were significantly lower in recurrent than non-recurrent BPPV across all countries in the sample (WMD 2.59, 95% CI 0.35-4.82, p = 0.023). Vitamin D deficiency emerged as an independent risk factor of BPPV (OR 1.998, 95% CI 1.400-2.851, p < 0.001).

CONCLUSION

The available evidence suggests that BPPV is associated with decreased levels of serum Vitamin D, and vitamin D deficiency was an independent risk factor for BPPV.

Authors+Show Affiliations

Department of Neurology, Seventh People's Hospital of Chengdu, Chengdu, 610041, Sichuan, People's Republic of China.Department of Endocrinology, Seventh People's Hospital of Chengdu, Chengdu, 610041, Sichuan, People's Republic of China.Department of Neurology, The Third People's Hospital of Yunnan Province, Kunming, 650011, Yunnan, People's Republic of China.Department of Neurology, Seventh People's Hospital of Chengdu, Chengdu, 610041, Sichuan, People's Republic of China.Department of Neurology, Seventh People's Hospital of Chengdu, Chengdu, 610041, Sichuan, People's Republic of China.Department of Endocrinology, Seventh People's Hospital of Chengdu, Chengdu, 610041, Sichuan, People's Republic of China.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People's Republic of China. yxldoc11@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31630244

Citation

Yang, Baiyuan, et al. "Association Between Serum Vitamin D Levels and Benign Paroxysmal Positional Vertigo: a Systematic Review and Meta-analysis of Observational Studies." European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2019.
Yang B, Lu Y, Xing D, et al. Association between serum vitamin D levels and benign paroxysmal positional vertigo: a systematic review and meta-analysis of observational studies. Eur Arch Otorhinolaryngol. 2019.
Yang, B., Lu, Y., Xing, D., Zhong, W., Tang, Q., Liu, J., & Yang, X. (2019). Association between serum vitamin D levels and benign paroxysmal positional vertigo: a systematic review and meta-analysis of observational studies. European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, doi:10.1007/s00405-019-05694-0.
Yang B, et al. Association Between Serum Vitamin D Levels and Benign Paroxysmal Positional Vertigo: a Systematic Review and Meta-analysis of Observational Studies. Eur Arch Otorhinolaryngol. 2019 Oct 19; PubMed PMID: 31630244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between serum vitamin D levels and benign paroxysmal positional vertigo: a systematic review and meta-analysis of observational studies. AU - Yang,Baiyuan, AU - Lu,Yongxia, AU - Xing,Dongmei, AU - Zhong,Wei, AU - Tang,Qing, AU - Liu,Jingyu, AU - Yang,Xinglong, Y1 - 2019/10/19/ PY - 2019/09/04/received PY - 2019/10/08/accepted PY - 2019/10/21/entrez PY - 2019/10/21/pubmed PY - 2019/10/21/medline KW - Benign paroxysmal positional vertigo KW - Meta-analysis KW - Otolithiasis KW - Serum vitamin D JF - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery JO - Eur Arch Otorhinolaryngol N2 - OBJECTIVE: Benign paroxysmal positional vertigo (BPPV) was the most common neuro-otological disorder manifests as recurrent positional vertigo, but its risk factors are elusive. Recent studies suggest that decreased Vitamin D level may be a risk factor, but the literature is inconsistent. METHODS: The databases PubMed, Web of Science, Chinese National Knowledge Infrastructure, Wanfang, SinoMed, and Embase were systematically searched for studies on the association between BPPV and serum Vitamin D levels published up to June 2019. Data from eligible studies were meta-analyzed using Stata 12.0. RESULTS: A total of 18 studies were included in the analysis. Serum Vitamin D levels were significantly lower in individuals with BPPV than in controls (WMD - 2.46, 95% CI - 3.79 to - 1.12, p < 0.001). Subgroup analysis by geographical area showed that vitamin D level was significantly lower in BPPV than in controls in China (WMD - 3.27, 95% CI - 4.12 to - 2.43, p < 0.001), but not outside China (WMD - 0.90, 95% CI - 4.36 to 2.56, p = 0.611). Vitamin D levels were significantly lower in recurrent than non-recurrent BPPV across all countries in the sample (WMD 2.59, 95% CI 0.35-4.82, p = 0.023). Vitamin D deficiency emerged as an independent risk factor of BPPV (OR 1.998, 95% CI 1.400-2.851, p < 0.001). CONCLUSION: The available evidence suggests that BPPV is associated with decreased levels of serum Vitamin D, and vitamin D deficiency was an independent risk factor for BPPV. SN - 1434-4726 UR - https://www.unboundmedicine.com/medline/citation/31630244/Association_between_serum_vitamin_D_levels_and_benign_paroxysmal_positional_vertigo:_a_systematic_review_and_meta-analysis_of_observational_studies L2 - https://dx.doi.org/10.1007/s00405-019-05694-0 DB - PRIME DP - Unbound Medicine ER -