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Neurological disorders and mitochondria.
Mol Aspects Med. 2020 02; 71:100826.MA

Abstract

The brain is highly dependent on mitochondrial energy metabolism. As a result, mitochondrial dysfunction is a central aspect of many adult-onset neurological diseases, including stroke, ALS, Alzheimer's, Huntington's, and Parkinson's diseases. We review here how different mitochondrial functions, including oxidative phosphorylation, mitochondrial dynamics, oxidant generation, cell death regulation, Ca2+ homeostasis, and proteostasis are involved in these disorders.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Cabral-Costa JV
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, São Paulo, SP, 05508-000, Brazil. Electronic address: joao.victor.costa@usp.br.
Kowaltowski AJ
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, São Paulo, SP, 05508-000, Brazil. Electronic address: alicia@iq.usp.br.

MeSH

Calcium SignalingEnergy MetabolismHumansMitochondriaMitochondrial DynamicsNeurodegenerative DiseasesOxidative PhosphorylationOxidative StressProteostasisReactive Oxygen Species

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

31630771

Citation

Cabral-Costa, J V., and A J. Kowaltowski. "Neurological Disorders and Mitochondria." Molecular Aspects of Medicine, vol. 71, 2020, p. 100826.
Cabral-Costa JV, Kowaltowski AJ. Neurological disorders and mitochondria. Mol Aspects Med. 2020;71:100826.
Cabral-Costa, J. V., & Kowaltowski, A. J. (2020). Neurological disorders and mitochondria. Molecular Aspects of Medicine, 71, 100826. https://doi.org/10.1016/j.mam.2019.10.003
Cabral-Costa JV, Kowaltowski AJ. Neurological Disorders and Mitochondria. Mol Aspects Med. 2020;71:100826. PubMed PMID: 31630771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurological disorders and mitochondria. AU - Cabral-Costa,J V, AU - Kowaltowski,A J, Y1 - 2019/10/17/ PY - 2019/08/21/received PY - 2019/10/13/revised PY - 2019/10/13/accepted PY - 2019/10/22/pubmed PY - 2021/2/9/medline PY - 2019/10/22/entrez KW - Calcium KW - Mitochondria KW - Mitophagy KW - Neurodegeneration KW - Reactive oxygen species SP - 100826 EP - 100826 JF - Molecular aspects of medicine JO - Mol Aspects Med VL - 71 N2 - The brain is highly dependent on mitochondrial energy metabolism. As a result, mitochondrial dysfunction is a central aspect of many adult-onset neurological diseases, including stroke, ALS, Alzheimer's, Huntington's, and Parkinson's diseases. We review here how different mitochondrial functions, including oxidative phosphorylation, mitochondrial dynamics, oxidant generation, cell death regulation, Ca2+ homeostasis, and proteostasis are involved in these disorders. SN - 1872-9452 UR - https://www.unboundmedicine.com/medline/citation/31630771/Neurological_disorders_and_mitochondria_ DB - PRIME DP - Unbound Medicine ER -