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Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with vitamin B12 deficiency.
J Formos Med Assoc. 2020 Mar; 119(3):720-727.JF

Abstract

BACKGROUND/PURPOSE

Our previous study found that 56 of 1064 atrophic glossitis (AG) patients have vitamin B12 deficiency. This study assessed whether the AG patients with vitamin B12 deficiency (B12D/AG patients) had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than healthy control subjects.

METHODS

The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 56 B12D/AG patients and 532 healthy control subjects were measured and compared.

RESULTS

We found that 56 B12D/AG patients had significantly lower mean blood Hb and serum iron levels as well as significantly higher mean corpuscular volume (MCV) and mean serum homocysteine level than healthy control subjects (all P-values < 0.05). Moreover, 56 B12D/AG patients had significantly higher frequencies of macrocytosis (53.6%), blood Hb (64.3%), iron (26.8%), and folic acid (3.6%) deficiencies, hyperhomocysteinemia (89.3%), and serum GPCA positivity (55.4%) than 532 healthy control subjects (all P-values < 0.005). In addition, of 36 anemic B12D/AG patients, 22 (61.1%) had pernicious anemia (PA), 6 (16.7%) had macrocytic anemia other than PA, 4 (11.1%) had normocytic anemia, 3 (8.3%) had iron deficiency anemia (IDA), and one (2.8%) had microcytic anemia other than IDA and thalassemia trait-induced anemia.

CONCLUSION

We conclude that B12D/AG patients have significantly higher frequencies of macrocytosis, blood Hb, iron, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than healthy control subjects. PA is the most common type of anemia in our B12D/AG patients.

Authors+Show Affiliations

School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan; Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Walfare, New Taipei City, Taiwan.Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: andysun7702@yahoo.com.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31630933

Citation

Wu, Yang-Che, et al. "Anemia, Hematinic Deficiencies, Hyperhomocysteinemia, and Gastric Parietal Cell Antibody Positivity in Atrophic Glossitis Patients With Vitamin B12 Deficiency." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 119, no. 3, 2020, pp. 720-727.
Wu YC, Wu YH, Chang JY, et al. Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with vitamin B12 deficiency. J Formos Med Assoc. 2020;119(3):720-727.
Wu, Y. C., Wu, Y. H., Chang, J. Y., Wang, Y. P., Kuo, Y. S., & Sun, A. (2020). Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with vitamin B12 deficiency. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 119(3), 720-727. https://doi.org/10.1016/j.jfma.2019.10.002
Wu YC, et al. Anemia, Hematinic Deficiencies, Hyperhomocysteinemia, and Gastric Parietal Cell Antibody Positivity in Atrophic Glossitis Patients With Vitamin B12 Deficiency. J Formos Med Assoc. 2020;119(3):720-727. PubMed PMID: 31630933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with vitamin B12 deficiency. AU - Wu,Yang-Che, AU - Wu,Yu-Hsueh, AU - Chang,Julia Yu-Fong, AU - Wang,Yi-Ping, AU - Kuo,Ying-Shiung, AU - Sun,Andy, Y1 - 2019/10/18/ PY - 2019/09/20/received PY - 2019/10/02/accepted PY - 2019/10/22/pubmed PY - 2020/3/20/medline PY - 2019/10/22/entrez KW - Atrophic glossitis KW - Hyperhomocysteinemia KW - Iron deficiency KW - Pernicious anemia KW - Vitamin B12 deficiency SP - 720 EP - 727 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 119 IS - 3 N2 - BACKGROUND/PURPOSE: Our previous study found that 56 of 1064 atrophic glossitis (AG) patients have vitamin B12 deficiency. This study assessed whether the AG patients with vitamin B12 deficiency (B12D/AG patients) had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than healthy control subjects. METHODS: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 56 B12D/AG patients and 532 healthy control subjects were measured and compared. RESULTS: We found that 56 B12D/AG patients had significantly lower mean blood Hb and serum iron levels as well as significantly higher mean corpuscular volume (MCV) and mean serum homocysteine level than healthy control subjects (all P-values < 0.05). Moreover, 56 B12D/AG patients had significantly higher frequencies of macrocytosis (53.6%), blood Hb (64.3%), iron (26.8%), and folic acid (3.6%) deficiencies, hyperhomocysteinemia (89.3%), and serum GPCA positivity (55.4%) than 532 healthy control subjects (all P-values < 0.005). In addition, of 36 anemic B12D/AG patients, 22 (61.1%) had pernicious anemia (PA), 6 (16.7%) had macrocytic anemia other than PA, 4 (11.1%) had normocytic anemia, 3 (8.3%) had iron deficiency anemia (IDA), and one (2.8%) had microcytic anemia other than IDA and thalassemia trait-induced anemia. CONCLUSION: We conclude that B12D/AG patients have significantly higher frequencies of macrocytosis, blood Hb, iron, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than healthy control subjects. PA is the most common type of anemia in our B12D/AG patients. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/31630933/Anemia_hematinic_deficiencies_hyperhomocysteinemia_and_gastric_parietal_cell_antibody_positivity_in_atrophic_glossitis_patients_with_vitamin_B12_deficiency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(19)30827-7 DB - PRIME DP - Unbound Medicine ER -