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The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica.
Mycology 2019; 10(4):222-228M

Abstract

A new compound, nigronapthaphenyl, was extracted from the endophytic fungus Nigrospora sphaerica isolated from a mangrove plant Bruguiera gymnorrhyza. The structure of the compound was elucidated by analysis of 1D and 2D NMR spectra and mass spectrometric data. It was tested in vitro for its antimicrobial activity, cytotoxicity, anti-inflammatory activity and for its ability to inhibit α-glucosidase. Nigronapthaphenyl showed antibacterial activities against Bacillus subtilis TISTR 088 and Bacillus cereus TISTR 688 with MIC values of 4 and 2 μg/mL respectively. Cytotoxicity against colon cancer cell line HCT 116 was found to be an IC50 value of 9.62 ± 0.5 μM . This further showed potential anti-inflammatory activity amounting to an IC50 of 6.2 ± 0.5 μM and also α-glucosidase inhibitory activity, with an IC50 value of 6.9 ± 0.5 μM.

Authors+Show Affiliations

Department of Chemistry, University of Colombo, Colombo, Sri Lanka. Department of Chemistry and Earth, Ocean and Atmospheric Science, University of British Columbia (UBC), Vancouver, Canada.AMEDA Diagnostics, Krenngasse, Austria.Department of Chemistry, University of Colombo, Colombo, Sri Lanka.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31632831

Citation

Ukwatta, Kushan M., et al. "The Study of Antimicrobial, Anti-cancer, Anti-inflammatory and Α-glucosidase Inhibitory Activities of Nigronapthaphenyl, Isolated From an Extract of Nigrospora Sphaerica." Mycology, vol. 10, no. 4, 2019, pp. 222-228.
Ukwatta KM, Lawrence JL, Wijayarathna CD. The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica. Mycology. 2019;10(4):222-228.
Ukwatta, K. M., Lawrence, J. L., & Wijayarathna, C. D. (2019). The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica. Mycology, 10(4), pp. 222-228. doi:10.1080/21501203.2019.1620892.
Ukwatta KM, Lawrence JL, Wijayarathna CD. The Study of Antimicrobial, Anti-cancer, Anti-inflammatory and Α-glucosidase Inhibitory Activities of Nigronapthaphenyl, Isolated From an Extract of Nigrospora Sphaerica. Mycology. 2019;10(4):222-228. PubMed PMID: 31632831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica. AU - Ukwatta,Kushan M, AU - Lawrence,Jennifer L, AU - Wijayarathna,C D, Y1 - 2019/05/24/ PY - 2019/04/27/received PY - 2019/05/13/accepted PY - 2019/10/22/entrez PY - 2019/10/22/pubmed PY - 2019/10/22/medline KW - Bruguiera gymnorrhyza KW - Endophytic fungi KW - Nigronapthaphenyl KW - Nigrospora sphaerica SP - 222 EP - 228 JF - Mycology JO - Mycology VL - 10 IS - 4 N2 - A new compound, nigronapthaphenyl, was extracted from the endophytic fungus Nigrospora sphaerica isolated from a mangrove plant Bruguiera gymnorrhyza. The structure of the compound was elucidated by analysis of 1D and 2D NMR spectra and mass spectrometric data. It was tested in vitro for its antimicrobial activity, cytotoxicity, anti-inflammatory activity and for its ability to inhibit α-glucosidase. Nigronapthaphenyl showed antibacterial activities against Bacillus subtilis TISTR 088 and Bacillus cereus TISTR 688 with MIC values of 4 and 2 μg/mL respectively. Cytotoxicity against colon cancer cell line HCT 116 was found to be an IC50 value of 9.62 ± 0.5 μM . This further showed potential anti-inflammatory activity amounting to an IC50 of 6.2 ± 0.5 μM and also α-glucosidase inhibitory activity, with an IC50 value of 6.9 ± 0.5 μM. SN - 2150-1203 UR - https://www.unboundmedicine.com/medline/citation/31632831/The_study_of_antimicrobial,_anti-cancer,_anti-inflammatory_and_α-glucosidase_inhibitory_activities_of_Nigronapthaphenyl,_isolated_from_an_extract_of_Nigrospora_sphaerica L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31632831/ DB - PRIME DP - Unbound Medicine ER -