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CD8+ cytotoxic mycosis fungoides: a retrospective analysis of clinical features and follow-up results of 29 patients.

Abstract

BACKGROUND AND OBJECTIVE

Less than 5% of cases of mycosis fungoides (MF) present with a cytotoxic/suppressor CD8+ phenotype. This study aimed to evaluate the clinical characteristics, treatment modalities, and clinical course in CD8+ MF patients.

METHODS

In a retrospective analysis of 353 MF patients in a referral center at Ankara University, Turkey, 29 patients that were diagnosed with CD8+ MF were included in the study.

RESULTS

CD8+ MF cases constituted 8.2% of all MF patients. The age at the time of diagnosis ranged between 6 and 81 years with a median value of 46 years. The female-to-male ratio was 1.41. Patients presented with erythematous scaly (69%), hyperpigmented (58.6%), poikilodermic (17.2%), and hypopigmented (17.2 %) patches/plaques. The most common sites of involvement were the trunk and lower extremities. The most common comorbidity was hypertension (24.1%, n: 7) with 13 patients (44.8%) having a history of at least one autoimmune disease. At the time of diagnosis, 93.2% of the patients had early-stage disease, and 6.8% of the patients had advanced stage. The mean follow-up period was 6.68 ± 6.04 years (range 1-28 years). Most of the patients were treated with skin-directed therapies. Complete remission was achieved in 17 (58.6%) patients, eight (27.6%) patients had partial remission, and four (13.8%) patients had stable disease.

CONCLUSIONS

We concluded that CD8+ MF is associated with an indolent course and in most patients, skin-directed therapies were found to be efficient to control the disease.

Authors+Show Affiliations

Department of Dermatology, Faculty of Medicine, Ankara University, Ankara, Turkey.Department of Dermatology, Faculty of Medicine, Ankara University, Ankara, Turkey.Department of Dermatology, Faculty of Medicine, Ankara University, Ankara, Turkey.Department of Dermatology, Faculty of Medicine, Ankara University, Ankara, Turkey.Department of Pathology, Faculty of Medicine, Ankara University, Ankara, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31633200

Citation

Kalay Yildizhan, Incilay, et al. "CD8+ Cytotoxic Mycosis Fungoides: a Retrospective Analysis of Clinical Features and Follow-up Results of 29 Patients." International Journal of Dermatology, 2019.
Kalay Yildizhan I, Sanli H, Akay BN, et al. CD8+ cytotoxic mycosis fungoides: a retrospective analysis of clinical features and follow-up results of 29 patients. Int J Dermatol. 2019.
Kalay Yildizhan, I., Sanli, H., Akay, B. N., Sürgün, E., & Heper, A. (2019). CD8+ cytotoxic mycosis fungoides: a retrospective analysis of clinical features and follow-up results of 29 patients. International Journal of Dermatology, doi:10.1111/ijd.14689.
Kalay Yildizhan I, et al. CD8+ Cytotoxic Mycosis Fungoides: a Retrospective Analysis of Clinical Features and Follow-up Results of 29 Patients. Int J Dermatol. 2019 Oct 21; PubMed PMID: 31633200.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD8+ cytotoxic mycosis fungoides: a retrospective analysis of clinical features and follow-up results of 29 patients. AU - Kalay Yildizhan,Incilay, AU - Sanli,Hatice, AU - Akay,Bengu N, AU - Sürgün,Ece, AU - Heper,Aylin, Y1 - 2019/10/21/ PY - 2019/06/24/received PY - 2019/09/14/revised PY - 2019/09/20/accepted PY - 2019/10/22/entrez JF - International journal of dermatology JO - Int. J. Dermatol. N2 - BACKGROUND AND OBJECTIVE: Less than 5% of cases of mycosis fungoides (MF) present with a cytotoxic/suppressor CD8+ phenotype. This study aimed to evaluate the clinical characteristics, treatment modalities, and clinical course in CD8+ MF patients. METHODS: In a retrospective analysis of 353 MF patients in a referral center at Ankara University, Turkey, 29 patients that were diagnosed with CD8+ MF were included in the study. RESULTS: CD8+ MF cases constituted 8.2% of all MF patients. The age at the time of diagnosis ranged between 6 and 81 years with a median value of 46 years. The female-to-male ratio was 1.41. Patients presented with erythematous scaly (69%), hyperpigmented (58.6%), poikilodermic (17.2%), and hypopigmented (17.2 %) patches/plaques. The most common sites of involvement were the trunk and lower extremities. The most common comorbidity was hypertension (24.1%, n: 7) with 13 patients (44.8%) having a history of at least one autoimmune disease. At the time of diagnosis, 93.2% of the patients had early-stage disease, and 6.8% of the patients had advanced stage. The mean follow-up period was 6.68 ± 6.04 years (range 1-28 years). Most of the patients were treated with skin-directed therapies. Complete remission was achieved in 17 (58.6%) patients, eight (27.6%) patients had partial remission, and four (13.8%) patients had stable disease. CONCLUSIONS: We concluded that CD8+ MF is associated with an indolent course and in most patients, skin-directed therapies were found to be efficient to control the disease. SN - 1365-4632 UR - https://www.unboundmedicine.com/medline/citation/31633200/CD8+_cytotoxic_mycosis_fungoides:_a_retrospective_analysis_of_clinical_features_and_follow-up_results_of_29_patients L2 - https://doi.org/10.1111/ijd.14689 DB - PRIME DP - Unbound Medicine ER -