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Age, height, BMI and FBG predict prostate volume in ageing benign prostatic hyperplasia: Evidence from 5285 patients.
Int J Clin Pract 2019; :e13438IJ

Abstract

AIMS

Several studies have reported a potential association between prostate volume (PV) and prostate disease. Here, we classified the risk factors for PV among benign prostatic hyperplasia (BPH) patients.

METHODS

In all, 4293 BPH patients with available clinical information were enrolled. Body mass index (BMI) was obtained as weight divided by height squared. PV was calculated as length × width × height (cm) × π/6. Mann-Whitney U tests were used to determine the differences between PV subgroups. Univariate and multiple linear regression tests were performed to uncover the connection between clinical features and PV. The differences in the age, BMI, height and fasting blood glucose (FBG) of the subgroups were evaluated by Kruskal-Wallis tests and adjusted with Bonferroni post hoc correction. A nomogram was created to directly illustrate the mutual interaction of amalgamator parameters.

RESULTS

PV did not influence the incidence of kidney stones (P = .815), whereas prostate calculi were positively associated with an enlarged prostate (>30 mL) (P < .001). Age (adjusted R = 0.363, P < .001), height (adjusted R = 0.088, P < .001), BMI (adjusted R = 0.039, P = .013) and FBG (adjusted R = -0.034, P = .027) were the independent risk/protective factors related to enlarged PV among BPH patients. The nomogram illustrated the predictive risk of an enlarged prostate (>30 mL) in men. The area under the ROC curve value was 0.659 in the training cohort and 0.677 in an internal validation cohort.

CONCLUSIONS

Age, height and BMI were positive independent risk factors of enlarged PV in BPH patients, and FBG had a protective role.

Authors+Show Affiliations

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. Institute of Urology, Anhui Medical University, Hefei, Anhui, China. Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, Anhui, China. Department of Health Examination Center, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. Institute of Urology, Anhui Medical University, Hefei, Anhui, China. Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, Anhui, China.Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.Department of Health Examination Center, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.Department of Health Examination Center, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. Institute of Urology, Anhui Medical University, Hefei, Anhui, China. Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, Anhui, China.Department of Health Examination Center, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. Institute of Urology, Anhui Medical University, Hefei, Anhui, China. Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, Anhui, China.Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. Institute of Urology, Anhui Medical University, Hefei, Anhui, China. Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, Anhui, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31633263

Citation

Meng, Jialin, et al. "Age, Height, BMI and FBG Predict Prostate Volume in Ageing Benign Prostatic Hyperplasia: Evidence From 5285 Patients." International Journal of Clinical Practice, 2019, pp. e13438.
Meng J, Liu Y, Guan SY, et al. Age, height, BMI and FBG predict prostate volume in ageing benign prostatic hyperplasia: Evidence from 5285 patients. Int J Clin Pract. 2019.
Meng, J., Liu, Y., Guan, S. Y., Ma, H., Zhang, X., Fan, S., ... Liang, C. (2019). Age, height, BMI and FBG predict prostate volume in ageing benign prostatic hyperplasia: Evidence from 5285 patients. International Journal of Clinical Practice, pp. e13438. doi:10.1111/ijcp.13438.
Meng J, et al. Age, Height, BMI and FBG Predict Prostate Volume in Ageing Benign Prostatic Hyperplasia: Evidence From 5285 Patients. Int J Clin Pract. 2019 Oct 21;e13438. PubMed PMID: 31633263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age, height, BMI and FBG predict prostate volume in ageing benign prostatic hyperplasia: Evidence from 5285 patients. AU - Meng,Jialin, AU - Liu,Yi, AU - Guan,Shi-Yang, AU - Ma,Huiya, AU - Zhang,Xiaoyu, AU - Fan,Song, AU - Hu,Huaqing, AU - Zhang,Meng, AU - Liang,Chaozhao, Y1 - 2019/10/21/ PY - 2019/07/16/received PY - 2019/10/09/revised PY - 2019/10/13/accepted PY - 2019/10/22/pubmed PY - 2019/10/22/medline PY - 2019/10/22/entrez SP - e13438 EP - e13438 JF - International journal of clinical practice JO - Int. J. Clin. Pract. N2 - AIMS: Several studies have reported a potential association between prostate volume (PV) and prostate disease. Here, we classified the risk factors for PV among benign prostatic hyperplasia (BPH) patients. METHODS: In all, 4293 BPH patients with available clinical information were enrolled. Body mass index (BMI) was obtained as weight divided by height squared. PV was calculated as length × width × height (cm) × π/6. Mann-Whitney U tests were used to determine the differences between PV subgroups. Univariate and multiple linear regression tests were performed to uncover the connection between clinical features and PV. The differences in the age, BMI, height and fasting blood glucose (FBG) of the subgroups were evaluated by Kruskal-Wallis tests and adjusted with Bonferroni post hoc correction. A nomogram was created to directly illustrate the mutual interaction of amalgamator parameters. RESULTS: PV did not influence the incidence of kidney stones (P = .815), whereas prostate calculi were positively associated with an enlarged prostate (>30 mL) (P < .001). Age (adjusted R = 0.363, P < .001), height (adjusted R = 0.088, P < .001), BMI (adjusted R = 0.039, P = .013) and FBG (adjusted R = -0.034, P = .027) were the independent risk/protective factors related to enlarged PV among BPH patients. The nomogram illustrated the predictive risk of an enlarged prostate (>30 mL) in men. The area under the ROC curve value was 0.659 in the training cohort and 0.677 in an internal validation cohort. CONCLUSIONS: Age, height and BMI were positive independent risk factors of enlarged PV in BPH patients, and FBG had a protective role. SN - 1742-1241 UR - https://www.unboundmedicine.com/medline/citation/31633263/Age,_height,_BMI_and_FBG_predict_prostate_volume_in_aging_benign_prostatic_hyperplasia:_Evidence_from_5285_patients L2 - https://doi.org/10.1111/ijcp.13438 DB - PRIME DP - Unbound Medicine ER -